| 1 | 27/8/2021 | 21 1-0 v NantesNantes 0-1 Lyon | French Ligue 1 |
| 2 | 25/9/2021 | 211-1 v LorientLyon 1-1 Lorient | French Ligue 1 |
| 3 | 4/11/2021 | 213-0 v Sparta PragueLyon 3-0 Sparta Prague | UEFA Europa League Group A |
| 4 | 28/11/2021 | 211-0 v MontpellierMontpellier 0-1 Lyon | French Ligue 1 |
| 5 | 5/12/2021 | 212-2 v BordeauxBordeaux 2-2 Lyon | French Ligue 1 |
| 6 | 9/12/2021 | 211-1 v RangersLyon 1-1 Rangers | UEFA Europa League Group A |
| 7 | 12/12/2021 | 21 0-0 v LilleLille 0-0 Lyon | French Ligue 1 |
| 8 | 22/12/2021 | 21 1-1 v MetzLyon 1-1 Metz | French Ligue 1 |
| 9 | 9/1/2022 | 211-1 v Paris St GermainLyon 1-1 Paris St Germain | French Ligue 1 |
| 10 | 21/1/2022 | 21 1-0 v Saint ÉtienneLyon 1-0 Saint Étienne | French Ligue 1 |
| 11 | 13/3/2022 | 212-4 v RennesLyon 2-4 Rennes | French Ligue 1 |
| 12 | 10/4/2022 | 211-1 v StrasbourgStrasbourg 1-1 Lyon | French Ligue 1 |
| 13 | 20/4/2022 | 211-2 v BrestBrest 2-1 Lyon | French Ligue 1 |
| 14 | 23/4/2022 | 215-2 v MontpellierLyon 5-2 Montpellier | French Ligue 1 |
| 15 | 14/5/2022 | 213-2 v NantesLyon 3-2 Nantes | French Ligue 1 |
| 16 | 21/5/2022 | 212-1 v ClermontClermont 1-2 Lyon | French Ligue 1 |
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