| 1 | 7/8/2021 | 101-1 v BrestLyon 1-1 Brest | French Ligue 1 |
| 2 | 15/8/2021 | 100-3 v AngersAngers 3-0 Lyon | French Ligue 1 |
| 3 | 27/8/2021 | 101-0 v NantesNantes 0-1 Lyon | French Ligue 1 |
| 4 | 12/9/2021 | 103-1 v StrasbourgLyon 3-1 Strasbourg | French Ligue 1 |
| 5 | 16/9/2021 | 102-0 v RangersRangers 0-2 Lyon | UEFA Europa League Group A |
| 6 | 19/9/2021 | 101-2 v Paris St GermainParis St Germain 2-1 Lyon | French Ligue 1 |
| 7 | 25/9/2021 | 101-1 v LorientLyon 1-1 Lorient | French Ligue 1 |
| 8 | 3/10/2021 | 101-1 v Saint ÉtienneSaint Étienne 1-1 Lyon | French Ligue 1 |
| 9 | 16/10/2021 | 102-0 v MonacoLyon 2-0 Monaco | French Ligue 1 |
| 10 | 21/10/2021 | 10 4-3 v Sparta PragueSparta Prague 3-4 Lyon | UEFA Europa League Group A |
| 11 | 24/10/2021 | 102-3 v NiceNice 3-2 Lyon | French Ligue 1 |
| 12 | 30/10/2021 | 10 2-1 v LensLyon 2-1 Lens | French Ligue 1 |
| 13 | 4/11/2021 | 103-0 v Sparta PragueLyon 3-0 Sparta Prague | UEFA Europa League Group A |
| 14 | 7/11/2021 | 101-4 v RennesRennes 4-1 Lyon | French Ligue 1 |
| 15 | 28/11/2021 | 101-0 v MontpellierMontpellier 0-1 Lyon | French Ligue 1 |
| 16 | 1/12/2021 | 10 1-2 v ReimsLyon 1-2 Reims | French Ligue 1 |
| 17 | 5/12/2021 | 102-2 v BordeauxBordeaux 2-2 Lyon | French Ligue 1 |
| 18 | 22/12/2021 | 101-1 v MetzLyon 1-1 Metz | French Ligue 1 |
| 19 | 9/1/2022 | 101-1 v Paris St GermainLyon 1-1 Paris St Germain | French Ligue 1 |
| 20 | 21/1/2022 | 101-0 v Saint ÉtienneLyon 1-0 Saint Étienne | French Ligue 1 |
| 21 | 1/2/2022 | 102-1 v MarseilleLyon 2-1 Marseille | French Ligue 1 |
| 22 | 5/2/2022 | 100-2 v MonacoMonaco 2-0 Lyon | French Ligue 1 |
| 23 | 12/2/2022 | 102-0 v NiceLyon 2-0 Nice | French Ligue 1 |
| 24 | 19/2/2022 | 101-1 v LensLens 1-1 Lyon | French Ligue 1 |
| 25 | 27/2/2022 | 100-1 v LilleLyon 0-1 Lille | French Ligue 1 |
| 26 | 4/3/2022 | 104-1 v LorientLorient 1-4 Lyon | French Ligue 1 |
| 27 | 9/3/2022 | 101-0 v FC PortoFC Porto 0-1 Lyon | UEFA Europa League Round of 16 |
| 28 | 13/3/2022 | 102-4 v RennesLyon 2-4 Rennes | French Ligue 1 |
| 29 | 17/3/2022 | 101-1 v FC PortoLyon 1-1 FC Porto | UEFA Europa League Round of 16 |
| 30 | 20/3/2022 | 100-0 v ReimsReims 0-0 Lyon | French Ligue 1 |
| 31 | 3/4/2022 | 103-2 v AngersLyon 3-2 Angers | French Ligue 1 |
| 32 | 7/4/2022 | 101-1 v West Ham UnitedWest Ham United 1-1 Lyon | UEFA Europa League Quarter Final |
| 33 | 10/4/2022 | 101-1 v StrasbourgStrasbourg 1-1 Lyon | French Ligue 1 |
| 34 | 14/4/2022 | 100-3 v West Ham UnitedLyon 0-3 West Ham United | UEFA Europa League Quarter Final |
| 35 | 17/4/2022 | 106-1 v BordeauxLyon 6-1 Bordeaux | French Ligue 1 |
| 36 | 20/4/2022 | 101-2 v BrestBrest 2-1 Lyon | French Ligue 1 |
| 37 | 23/4/2022 | 105-2 v MontpellierLyon 5-2 Montpellier | French Ligue 1 |
| 38 | 1/5/2022 | 103-0 v MarseilleMarseille 0-3 Lyon | French Ligue 1 |
| 39 | 8/5/2022 | 102-3 v MetzMetz 3-2 Lyon | French Ligue 1 |
| 40 | 14/5/2022 | 103-2 v NantesLyon 3-2 Nantes | French Ligue 1 |
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