| 1 | Sun 20 Sep 2020 | 81-3 v RB LeipzigRB Leipzig 3-1 Mainz 05 | German Bundesliga |
| 2 | Sat 26 Sep 2020 | 81-4 v VfB StuttgartMainz 05 1-4 VfB Stuttgart | German Bundesliga |
| 3 | Sat 17 Oct 2020 | 80-1 v Bayer 04 LeverkusenMainz 05 0-1 Bayer 04 Leverkusen | German Bundesliga |
| 4 | Sat 24 Oct 2020 | 82-3 v Borussia MönchengladbachMainz 05 2-3 Borussia Mönchengladbach | German Bundesliga |
| 5 | Sat 31 Oct 2020 | 81-3 v FC AugsburgFC Augsburg 3-1 Mainz 05 | German Bundesliga |
| 6 | Sat 7 Nov 2020 | 82-2 v FC Schalke 04Mainz 05 2-2 FC Schalke 04 | German Bundesliga |
| 7 | Sun 22 Nov 2020 | 83-1 v SC FreiburgSC Freiburg 1-3 Mainz 05 | German Bundesliga |
| 8 | Sun 29 Nov 2020 | 81-1 v 1899 HoffenheimMainz 05 1-1 1899 Hoffenheim | German Bundesliga |
| 9 | Sat 9 Jan 2021 | 80-2 v Eintracht FrankfurtMainz 05 0-2 Eintracht Frankfurt | German Bundesliga |
| 10 | Sat 16 Jan 2021 | 81-1 v Borussia DortmundBorussia Dortmund 1-1 Mainz 05 | German Bundesliga |
| 11 | Tue 19 Jan 2021 | 80-2 v VfL WolfsburgMainz 05 0-2 VfL Wolfsburg | German Bundesliga |
| 12 | Sat 23 Jan 2021 | 83-2 v RB LeipzigMainz 05 3-2 RB Leipzig | German Bundesliga |
| 13 | Fri 29 Jan 2021 | 80-2 v VfB StuttgartVfB Stuttgart 2-0 Mainz 05 | German Bundesliga |
| 14 | Sun 28 Feb 2021 | 80-1 v FC AugsburgMainz 05 0-1 FC Augsburg | German Bundesliga |
| 15 | Sat 24 Apr 2021 | 82-1 v Bayern MunichMainz 05 2-1 Bayern Munich | German Bundesliga |
| 16 | Sun 9 May 2021 | 81-1 v Eintracht FrankfurtEintracht Frankfurt 1-1 Mainz 05 | German Bundesliga |
| 17 | Sat 22 May 2021 | 83-2 v VfL WolfsburgVfL Wolfsburg 2-3 Mainz 05 | German Bundesliga |
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