| 1 | Sat 16 Jan 2021 | 161-1 v Borussia DortmundBorussia Dortmund 1-1 Mainz 05 | German Bundesliga |
| 2 | Tue 19 Jan 2021 | 160-2 v VfL WolfsburgMainz 05 0-2 VfL Wolfsburg | German Bundesliga |
| 3 | Sat 23 Jan 2021 | 163-2 v RB LeipzigMainz 05 3-2 RB Leipzig | German Bundesliga |
| 4 | Fri 29 Jan 2021 | 16 0-2 v VfB StuttgartVfB Stuttgart 2-0 Mainz 05 | German Bundesliga |
| 5 | Sat 6 Feb 2021 | 161-0 v 1. FC Union BerlinMainz 05 1-0 1. FC Union Berlin | German Bundesliga |
| 6 | Sat 13 Feb 2021 | 162-2 v Bayer 04 LeverkusenBayer 04 Leverkusen 2-2 Mainz 05 | German Bundesliga |
| 7 | Sat 20 Feb 2021 | 162-1 v Borussia MönchengladbachBorussia Mönchengladbach 1-2 Mainz 05 | German Bundesliga |
| 8 | Sun 28 Feb 2021 | 160-1 v FC AugsburgMainz 05 0-1 FC Augsburg | German Bundesliga |
| 9 | Fri 5 Mar 2021 | 16 0-0 v FC Schalke 04FC Schalke 04 0-0 Mainz 05 | German Bundesliga |
| 10 | Sat 13 Mar 2021 | 16 1-0 v SC FreiburgMainz 05 1-0 SC Freiburg | German Bundesliga |
| 11 | Sun 21 Mar 2021 | 162-1 v 1899 Hoffenheim1899 Hoffenheim 1-2 Mainz 05 | German Bundesliga |
| 12 | Sat 3 Apr 2021 | 16 1-1 v Arminia BielefeldMainz 05 1-1 Arminia Bielefeld | German Bundesliga |
| 13 | Sun 11 Apr 2021 | 163-2 v 1. FC Köln1. FC Köln 2-3 Mainz 05 | German Bundesliga |
| 14 | Wed 21 Apr 2021 | 161-0 v Werder BremenWerder Bremen 0-1 Mainz 05 | German Bundesliga |
| 15 | Mon 3 May 2021 | 16 1-1 v Hertha BerlinMainz 05 1-1 Hertha Berlin | German Bundesliga |
| 16 | Sat 22 May 2021 | 16 3-2 v VfL WolfsburgVfL Wolfsburg 2-3 Mainz 05 | German Bundesliga |
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