| 1 | Sat 3 Oct 2020 | 31-1 v Leeds UnitedLeeds United 1-1 Manchester City | Premier League |
| 2 | Sat 17 Oct 2020 | 3 1-0 v ArsenalManchester City 1-0 Arsenal | Premier League |
| 3 | Wed 21 Oct 2020 | 33-1 v FC PortoManchester City 3-1 FC Porto | UEFA Champions League Group C |
| 4 | Sat 24 Oct 2020 | 31-1 v West Ham UnitedWest Ham United 1-1 Manchester City | Premier League |
| 5 | Tue 27 Oct 2020 | 33-0 v MarseilleMarseille 0-3 Manchester City | UEFA Champions League Group C |
| 6 | Sat 31 Oct 2020 | 31-0 v Sheffield UnitedSheffield United 0-1 Manchester City | Premier League |
| 7 | Sun 8 Nov 2020 | 31-1 v LiverpoolManchester City 1-1 Liverpool | Premier League |
| 8 | Sat 21 Nov 2020 | 3 0-2 v Tottenham HotspurTottenham Hotspur 2-0 Manchester City | Premier League |
| 9 | Wed 25 Nov 2020 | 3 1-0 v OlympiakosOlympiakos 0-1 Manchester City | UEFA Champions League Group C |
| 10 | Sat 28 Nov 2020 | 35-0 v BurnleyManchester City 5-0 Burnley | Premier League |
| 11 | Tue 1 Dec 2020 | 30-0 v FC PortoFC Porto 0-0 Manchester City | UEFA Champions League Group C |
| 12 | Sat 5 Dec 2020 | 32-0 v FulhamManchester City 2-0 Fulham | Premier League |
| 13 | Sat 12 Dec 2020 | 30-0 v Manchester UnitedManchester United 0-0 Manchester City | Premier League |
| 14 | Tue 15 Dec 2020 | 31-1 v West Bromwich AlbionManchester City 1-1 West Bromwich Albion | Premier League |
| 15 | Sat 19 Dec 2020 | 31-0 v SouthamptonSouthampton 0-1 Manchester City | Premier League |
| 16 | Tue 22 Dec 2020 | 34-1 v ArsenalArsenal 1-4 Manchester City | Carabao Cup Quarter Final |
| 17 | Sat 26 Dec 2020 | 32-0 v Newcastle UnitedManchester City 2-0 Newcastle United | Premier League |
| 18 | Sun 3 Jan 2021 | 33-1 v ChelseaChelsea 1-3 Manchester City | Premier League |
| 19 | Wed 6 Jan 2021 | 32-0 v Manchester UnitedManchester United 0-2 Manchester City | Carabao Cup Semi Final |
| 20 | Sun 10 Jan 2021 | 33-0 v Birmingham CityManchester City 3-0 Birmingham City | Emirates FA Cup Third Round |
| 21 | Wed 13 Jan 2021 | 31-0 v Brighton & Hove AlbionManchester City 1-0 Brighton & Hove Albion | Premier League |
| 22 | Sun 17 Jan 2021 | 34-0 v Crystal PalaceManchester City 4-0 Crystal Palace | Premier League |
| 23 | Wed 20 Jan 2021 | 32-0 v Aston VillaManchester City 2-0 Aston Villa | Premier League |
| 24 | Sat 23 Jan 2021 | 33-1 v Cheltenham TownCheltenham Town 1-3 Manchester City | Emirates FA Cup Fourth Round |
| 25 | Tue 26 Jan 2021 | 35-0 v West Bromwich AlbionWest Bromwich Albion 0-5 Manchester City | Premier League |
| 26 | Sat 30 Jan 2021 | 31-0 v Sheffield UnitedManchester City 1-0 Sheffield United | Premier League |
| 27 | Wed 3 Feb 2021 | 32-0 v BurnleyBurnley 0-2 Manchester City | Premier League |
| 28 | Sun 7 Feb 2021 | 3 4-1 v LiverpoolLiverpool 1-4 Manchester City | Premier League |
| 29 | Wed 17 Feb 2021 | 33-1 v EvertonEverton 1-3 Manchester City | Premier League |
| 30 | Sun 21 Feb 2021 | 31-0 v ArsenalArsenal 0-1 Manchester City | Premier League |
| 31 | Wed 24 Feb 2021 | 32-0 v Borussia MönchengladbachBorussia Mönchengladbach 0-2 Manchester City | UEFA Champions League Round of 16 |
| 32 | Sat 27 Feb 2021 | 32-1 v West Ham UnitedManchester City 2-1 West Ham United | Premier League |
| 33 | Tue 2 Mar 2021 | 34-1 v Wolverhampton WanderersManchester City 4-1 Wolverhampton Wanderers | Premier League |
| 34 | Sun 7 Mar 2021 | 30-2 v Manchester UnitedManchester City 0-2 Manchester United | Premier League |
| 35 | Wed 10 Mar 2021 | 35-2 v SouthamptonManchester City 5-2 Southampton | Premier League |
| 36 | Sat 13 Mar 2021 | 33-0 v FulhamFulham 0-3 Manchester City | Premier League |
| 37 | Tue 16 Mar 2021 | 32-0 v Borussia MönchengladbachManchester City 2-0 Borussia Mönchengladbach | UEFA Champions League Round of 16 |
| 38 | Sat 20 Mar 2021 | 32-0 v EvertonEverton 0-2 Manchester City | Emirates FA Cup Sixth Round |
| 39 | Sat 3 Apr 2021 | 32-0 v Leicester CityLeicester City 0-2 Manchester City | Premier League |
| 40 | Tue 6 Apr 2021 | 32-1 v Borussia DortmundManchester City 2-1 Borussia Dortmund | UEFA Champions League Quarter Final |
| 41 | Wed 14 Apr 2021 | 32-1 v Borussia DortmundBorussia Dortmund 1-2 Manchester City | UEFA Champions League Quarter Final |
| 42 | Sat 17 Apr 2021 | 3 0-1 v ChelseaChelsea 1-0 Manchester City | Emirates FA Cup Semi Final |
| 43 | Wed 21 Apr 2021 | 32-1 v Aston VillaAston Villa 1-2 Manchester City | Premier League |
| 44 | Sun 25 Apr 2021 | 31-0 v Tottenham HotspurManchester City 1-0 Tottenham Hotspur | Carabao Cup Final |
| 45 | Wed 28 Apr 2021 | 32-1 v Paris St GermainParis St Germain 1-2 Manchester City | UEFA Champions League Semi Final |
| 46 | Tue 4 May 2021 | 32-0 v Paris St GermainManchester City 2-0 Paris St Germain | UEFA Champions League Semi Final |
| 47 | Sat 8 May 2021 | 31-2 v ChelseaManchester City 1-2 Chelsea | Premier League |
| 48 | Tue 18 May 2021 | 32-3 v Brighton & Hove AlbionBrighton & Hove Albion 3-2 Manchester City | Premier League |
| 49 | Sun 23 May 2021 | 3 5-0 v EvertonManchester City 5-0 Everton | Premier League |
| 50 | Sat 29 May 2021 | 30-1 v ChelseaManchester City 0-1 Chelsea | UEFA Champions League Final |
| 51 | Sat 7 Aug 2021 | 3 0-1 v Leicester CityLeicester City 1-0 Manchester City | Community Shield Final |
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