| 1 | Sun 15 Aug 2021 | 10 0-1 v Tottenham HotspurTottenham Hotspur 1-0 Manchester City | Premier League |
| 2 | Sat 21 Aug 2021 | 105-0 v Norwich CityManchester City 5-0 Norwich City | Premier League |
| 3 | Sat 28 Aug 2021 | 105-0 v ArsenalManchester City 5-0 Arsenal | Premier League |
| 4 | Sat 11 Sep 2021 | 101-0 v Leicester CityLeicester City 0-1 Manchester City | Premier League |
| 5 | Wed 15 Sep 2021 | 106-3 v RB LeipzigManchester City 6-3 RB Leipzig | UEFA Champions League Group A |
| 6 | Sat 18 Sep 2021 | 100-0 v SouthamptonManchester City 0-0 Southampton | Premier League |
| 7 | Sat 25 Sep 2021 | 101-0 v ChelseaChelsea 0-1 Manchester City | Premier League |
| 8 | Tue 28 Sep 2021 | 100-2 v Paris St GermainParis St Germain 2-0 Manchester City | UEFA Champions League Group A |
| 9 | Sun 3 Oct 2021 | 102-2 v LiverpoolLiverpool 2-2 Manchester City | Premier League |
| 10 | Tue 19 Oct 2021 | 105-1 v Club BruggeClub Brugge 1-5 Manchester City | UEFA Champions League Group A |
| 11 | Sat 23 Oct 2021 | 104-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-4 Manchester City | Premier League |
| 12 | Wed 27 Oct 2021 | 100-0 v West Ham UnitedWest Ham United 0-0 Manchester City | Carabao Cup Round of 16 |
| 13 | Sat 30 Oct 2021 | 100-2 v Crystal PalaceManchester City 0-2 Crystal Palace | Premier League |
| 14 | Wed 3 Nov 2021 | 104-1 v Club BruggeManchester City 4-1 Club Brugge | UEFA Champions League Group A |
| 15 | Wed 1 Dec 2021 | 102-1 v Aston VillaAston Villa 1-2 Manchester City | Premier League |
| 16 | Sat 4 Dec 2021 | 103-1 v WatfordWatford 1-3 Manchester City | Premier League |
| 17 | Tue 7 Dec 2021 | 101-2 v RB LeipzigRB Leipzig 2-1 Manchester City | UEFA Champions League Group A |
| 18 | Sat 11 Dec 2021 | 101-0 v Wolverhampton WanderersManchester City 1-0 Wolverhampton Wanderers | Premier League |
| 19 | Tue 14 Dec 2021 | 107-0 v Leeds UnitedManchester City 7-0 Leeds United | Premier League |
| 20 | Wed 29 Dec 2021 | 101-0 v BrentfordBrentford 0-1 Manchester City | Premier League |
| 21 | Sat 15 Jan 2022 | 101-0 v ChelseaManchester City 1-0 Chelsea | Premier League |
| 22 | Sat 22 Jan 2022 | 101-1 v SouthamptonSouthampton 1-1 Manchester City | Premier League |
| 23 | Sat 5 Feb 2022 | 104-1 v FulhamManchester City 4-1 Fulham | Emirates FA Cup Fourth Round |
| 24 | Wed 9 Feb 2022 | 102-0 v BrentfordManchester City 2-0 Brentford | Premier League |
| 25 | Tue 1 Mar 2022 | 102-0 v Peterborough UnitedPeterborough United 0-2 Manchester City | Emirates FA Cup Fifth Round |
| 26 | Sun 6 Mar 2022 | 104-1 v Manchester UnitedManchester City 4-1 Manchester United | Premier League |
| 27 | Mon 14 Mar 2022 | 10 0-0 v Crystal PalaceCrystal Palace 0-0 Manchester City | Premier League |
| 28 | Sun 20 Mar 2022 | 104-1 v SouthamptonSouthampton 1-4 Manchester City | Emirates FA Cup Sixth Round |
| 29 | Sat 2 Apr 2022 | 102-0 v BurnleyBurnley 0-2 Manchester City | Premier League |
| 30 | Tue 5 Apr 2022 | 101-0 v Atlético MadridManchester City 1-0 Atlético Madrid | UEFA Champions League Quarter Final |
| 31 | Sun 10 Apr 2022 | 102-2 v LiverpoolManchester City 2-2 Liverpool | Premier League |
| 32 | Sat 16 Apr 2022 | 102-3 v LiverpoolManchester City 2-3 Liverpool | Emirates FA Cup Semi Final |
| 33 | Sat 23 Apr 2022 | 105-1 v WatfordManchester City 5-1 Watford | Premier League |
| 34 | Sat 30 Apr 2022 | 10 4-0 v Leeds UnitedLeeds United 0-4 Manchester City | Premier League |
| 35 | Wed 4 May 2022 | 101-3 v Real MadridReal Madrid 3-1 Manchester City | UEFA Champions League Semi Final |
| 36 | Sun 8 May 2022 | 105-0 v Newcastle UnitedManchester City 5-0 Newcastle United | Premier League |
| 37 | Wed 11 May 2022 | 105-1 v Wolverhampton WanderersWolverhampton Wanderers 1-5 Manchester City | Premier League |
| 38 | Sun 15 May 2022 | 102-2 v West Ham UnitedWest Ham United 2-2 Manchester City | Premier League |
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