| 1 | Sat 21 Aug 2021 | 25-0 v Norwich CityManchester City 5-0 Norwich City | Premier League |
| 2 | Sat 28 Aug 2021 | 25-0 v ArsenalManchester City 5-0 Arsenal | Premier League |
| 3 | Sat 11 Sep 2021 | 21-0 v Leicester CityLeicester City 0-1 Manchester City | Premier League |
| 4 | Sat 18 Sep 2021 | 20-0 v SouthamptonManchester City 0-0 Southampton | Premier League |
| 5 | Sat 25 Sep 2021 | 21-0 v ChelseaChelsea 0-1 Manchester City | Premier League |
| 6 | Tue 28 Sep 2021 | 20-2 v Paris St GermainParis St Germain 2-0 Manchester City | UEFA Champions League Group A |
| 7 | Sun 3 Oct 2021 | 22-2 v LiverpoolLiverpool 2-2 Manchester City | Premier League |
| 8 | Tue 19 Oct 2021 | 25-1 v Club BruggeClub Brugge 1-5 Manchester City | UEFA Champions League Group A |
| 9 | Sat 23 Oct 2021 | 2 4-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-4 Manchester City | Premier League |
| 10 | Wed 27 Oct 2021 | 20-0 v West Ham UnitedWest Ham United 0-0 Manchester City | Carabao Cup Round of 16 |
| 11 | Sat 30 Oct 2021 | 20-2 v Crystal PalaceManchester City 0-2 Crystal Palace | Premier League |
| 12 | Wed 3 Nov 2021 | 24-1 v Club BruggeManchester City 4-1 Club Brugge | UEFA Champions League Group A |
| 13 | Sat 6 Nov 2021 | 22-0 v Manchester UnitedManchester United 0-2 Manchester City | Premier League |
| 14 | Sun 21 Nov 2021 | 23-0 v EvertonManchester City 3-0 Everton | Premier League |
| 15 | Wed 24 Nov 2021 | 22-1 v Paris St GermainManchester City 2-1 Paris St Germain | UEFA Champions League Group A |
| 16 | Sun 28 Nov 2021 | 22-1 v West Ham UnitedManchester City 2-1 West Ham United | Premier League |
| 17 | Sat 4 Dec 2021 | 23-1 v WatfordWatford 1-3 Manchester City | Premier League |
| 18 | Tue 7 Dec 2021 | 2 1-2 v RB LeipzigRB Leipzig 2-1 Manchester City | UEFA Champions League Group A |
| 19 | Fri 7 Jan 2022 | 2 4-1 v Swindon TownSwindon Town 1-4 Manchester City | Emirates FA Cup Third Round |
| 20 | Sat 15 Jan 2022 | 21-0 v ChelseaManchester City 1-0 Chelsea | Premier League |
| 21 | Sat 22 Jan 2022 | 21-1 v SouthamptonSouthampton 1-1 Manchester City | Premier League |
| 22 | Sat 5 Feb 2022 | 2 4-1 v FulhamManchester City 4-1 Fulham | Emirates FA Cup Fourth Round |
| 23 | Sat 12 Feb 2022 | 24-0 v Norwich CityNorwich City 0-4 Manchester City | Premier League |
| 24 | Sat 19 Feb 2022 | 22-3 v Tottenham HotspurManchester City 2-3 Tottenham Hotspur | Premier League |
| 25 | Sun 6 Mar 2022 | 24-1 v Manchester UnitedManchester City 4-1 Manchester United | Premier League |
| 26 | Mon 14 Mar 2022 | 20-0 v Crystal PalaceCrystal Palace 0-0 Manchester City | Premier League |
| 27 | Sun 20 Mar 2022 | 24-1 v SouthamptonSouthampton 1-4 Manchester City | Emirates FA Cup Sixth Round |
| 28 | Sat 2 Apr 2022 | 22-0 v BurnleyBurnley 0-2 Manchester City | Premier League |
| 29 | Sun 10 Apr 2022 | 22-2 v LiverpoolManchester City 2-2 Liverpool | Premier League |
| 30 | Wed 13 Apr 2022 | 20-0 v Atlético MadridAtlético Madrid 0-0 Manchester City | UEFA Champions League Quarter Final |
| 31 | Wed 4 May 2022 | 21-3 v Real MadridReal Madrid 3-1 Manchester City | UEFA Champions League Semi Final |
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