| 1 | Sun 15 Aug 2021 | 30-1 v Tottenham HotspurTottenham Hotspur 1-0 Manchester City | Premier League |
| 2 | Sat 21 Aug 2021 | 35-0 v Norwich CityManchester City 5-0 Norwich City | Premier League |
| 3 | Sat 28 Aug 2021 | 35-0 v ArsenalManchester City 5-0 Arsenal | Premier League |
| 4 | Sat 11 Sep 2021 | 31-0 v Leicester CityLeicester City 0-1 Manchester City | Premier League |
| 5 | Wed 15 Sep 2021 | 36-3 v RB LeipzigManchester City 6-3 RB Leipzig | UEFA Champions League Group A |
| 6 | Sat 18 Sep 2021 | 30-0 v SouthamptonManchester City 0-0 Southampton | Premier League |
| 7 | Sat 25 Sep 2021 | 3 1-0 v ChelseaChelsea 0-1 Manchester City | Premier League |
| 8 | Tue 28 Sep 2021 | 30-2 v Paris St GermainParis St Germain 2-0 Manchester City | UEFA Champions League Group A |
| 9 | Sun 3 Oct 2021 | 3 2-2 v LiverpoolLiverpool 2-2 Manchester City | Premier League |
| 10 | Sat 16 Oct 2021 | 32-0 v BurnleyManchester City 2-0 Burnley | Premier League |
| 11 | Tue 19 Oct 2021 | 35-1 v Club BruggeClub Brugge 1-5 Manchester City | UEFA Champions League Group A |
| 12 | Sat 23 Oct 2021 | 34-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-4 Manchester City | Premier League |
| 13 | Sat 30 Oct 2021 | 30-2 v Crystal PalaceManchester City 0-2 Crystal Palace | Premier League |
| 14 | Sat 6 Nov 2021 | 32-0 v Manchester UnitedManchester United 0-2 Manchester City | Premier League |
| 15 | Wed 24 Nov 2021 | 32-1 v Paris St GermainManchester City 2-1 Paris St Germain | UEFA Champions League Group A |
| 16 | Sun 28 Nov 2021 | 32-1 v West Ham UnitedManchester City 2-1 West Ham United | Premier League |
| 17 | Wed 1 Dec 2021 | 32-1 v Aston VillaAston Villa 1-2 Manchester City | Premier League |
| 18 | Sat 4 Dec 2021 | 33-1 v WatfordWatford 1-3 Manchester City | Premier League |
| 19 | Tue 7 Dec 2021 | 31-2 v RB LeipzigRB Leipzig 2-1 Manchester City | UEFA Champions League Group A |
| 20 | Sat 11 Dec 2021 | 3 1-0 v Wolverhampton WanderersManchester City 1-0 Wolverhampton Wanderers | Premier League |
| 21 | Tue 14 Dec 2021 | 3 7-0 v Leeds UnitedManchester City 7-0 Leeds United | Premier League |
| 22 | Sun 19 Dec 2021 | 34-0 v Newcastle UnitedNewcastle United 0-4 Manchester City | Premier League |
| 23 | Sun 26 Dec 2021 | 36-3 v Leicester CityManchester City 6-3 Leicester City | Premier League |
| 24 | Wed 29 Dec 2021 | 31-0 v BrentfordBrentford 0-1 Manchester City | Premier League |
| 25 | Sat 1 Jan 2022 | 32-1 v ArsenalArsenal 1-2 Manchester City | Premier League |
| 26 | Fri 7 Jan 2022 | 34-1 v Swindon TownSwindon Town 1-4 Manchester City | Emirates FA Cup Third Round |
| 27 | Sat 22 Jan 2022 | 31-1 v SouthamptonSouthampton 1-1 Manchester City | Premier League |
| 28 | Wed 9 Feb 2022 | 32-0 v BrentfordManchester City 2-0 Brentford | Premier League |
| 29 | Sat 12 Feb 2022 | 3 4-0 v Norwich CityNorwich City 0-4 Manchester City | Premier League |
| 30 | Tue 15 Feb 2022 | 35-0 v Sporting LisbonSporting Lisbon 0-5 Manchester City | UEFA Champions League Round of 16 |
| 31 | Sat 19 Feb 2022 | 32-3 v Tottenham HotspurManchester City 2-3 Tottenham Hotspur | Premier League |
| 32 | Sat 26 Feb 2022 | 31-0 v EvertonEverton 0-1 Manchester City | Premier League |
| 33 | Tue 1 Mar 2022 | 32-0 v Peterborough UnitedPeterborough United 0-2 Manchester City | Emirates FA Cup Fifth Round |
| 34 | Wed 20 Apr 2022 | 33-0 v Brighton & Hove AlbionManchester City 3-0 Brighton & Hove Albion | Premier League |
| 35 | Sat 23 Apr 2022 | 35-1 v WatfordManchester City 5-1 Watford | Premier League |
| 36 | Tue 26 Apr 2022 | 34-3 v Real MadridManchester City 4-3 Real Madrid | UEFA Champions League Semi Final |
| 37 | Sat 30 Apr 2022 | 34-0 v Leeds UnitedLeeds United 0-4 Manchester City | Premier League |
| 38 | Wed 4 May 2022 | 31-3 v Real MadridReal Madrid 3-1 Manchester City | UEFA Champions League Semi Final |
| 39 | Sun 8 May 2022 | 35-0 v Newcastle UnitedManchester City 5-0 Newcastle United | Premier League |
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