| 1 | Sat 8 Aug 2015 | 81-0 v Tottenham HotspurManchester United 1-0 Tottenham Hotspur | Barclays Premier League |
| 2 | Fri 14 Aug 2015 | 81-0 v Aston VillaAston Villa 0-1 Manchester United | Barclays Premier League |
| 3 | Tue 18 Aug 2015 | 83-1 v Club BruggeManchester United 3-1 Club Brugge | UEFA Champions League |
| 4 | Sat 22 Aug 2015 | 80-0 v Newcastle UnitedManchester United 0-0 Newcastle United | Barclays Premier League |
| 5 | Wed 26 Aug 2015 | 84-0 v Club BruggeClub Brugge 0-4 Manchester United | UEFA Champions League |
| 6 | Sun 30 Aug 2015 | 81-2 v Swansea CitySwansea City 2-1 Manchester United | Barclays Premier League |
| 7 | Sat 12 Sep 2015 | 83-1 v LiverpoolManchester United 3-1 Liverpool | Barclays Premier League |
| 8 | Tue 15 Sep 2015 | 81-2 v PSV EindhovenPSV Eindhoven 2-1 Manchester United | UEFA Champions League Group B |
| 9 | Sun 20 Sep 2015 | 83-2 v SouthamptonSouthampton 2-3 Manchester United | Barclays Premier League |
| 10 | Wed 23 Sep 2015 | 83-0 v Ipswich TownManchester United 3-0 Ipswich Town | Capital One Cup Third Round |
| 11 | Sat 26 Sep 2015 | 83-0 v SunderlandManchester United 3-0 Sunderland | Barclays Premier League |
| 12 | Wed 30 Sep 2015 | 82-1 v WolfsburgManchester United 2-1 Wolfsburg | UEFA Champions League Group B |
| 13 | Sun 4 Oct 2015 | 80-3 v ArsenalArsenal 3-0 Manchester United | Barclays Premier League |
| 14 | Sat 17 Oct 2015 | 83-0 v EvertonEverton 0-3 Manchester United | Barclays Premier League |
| 15 | Sun 25 Oct 2015 | 80-0 v Manchester CityManchester United 0-0 Manchester City | Barclays Premier League |
| 16 | Sat 31 Oct 2015 | 80-0 v Crystal PalaceCrystal Palace 0-0 Manchester United | Barclays Premier League |
| 17 | Tue 3 Nov 2015 | 81-0 v CSKA MoscowManchester United 1-0 CSKA Moscow | UEFA Champions League Group B |
| 18 | Sat 7 Nov 2015 | 82-0 v West Bromwich AlbionManchester United 2-0 West Bromwich Albion | Barclays Premier League |
| 19 | Sat 21 Nov 2015 | 82-1 v WatfordWatford 1-2 Manchester United | Barclays Premier League |
| 20 | Wed 25 Nov 2015 | 80-0 v PSV EindhovenManchester United 0-0 PSV Eindhoven | UEFA Champions League Group B |
| 21 | Sat 28 Nov 2015 | 81-1 v Leicester CityLeicester City 1-1 Manchester United | Barclays Premier League |
| 22 | Sat 5 Dec 2015 | 80-0 v West Ham UnitedManchester United 0-0 West Ham United | Barclays Premier League |
| 23 | Tue 8 Dec 2015 | 82-3 v WolfsburgWolfsburg 3-2 Manchester United | UEFA Champions League Group B |
| 24 | Sat 12 Dec 2015 | 81-2 v AFC BournemouthAFC Bournemouth 2-1 Manchester United | Barclays Premier League |
| 25 | Sat 19 Dec 2015 | 81-2 v Norwich CityManchester United 1-2 Norwich City | Barclays Premier League |
| 26 | Sat 26 Dec 2015 | 80-2 v Stoke CityStoke City 2-0 Manchester United | Barclays Premier League |
| 27 | Mon 28 Dec 2015 | 80-0 v ChelseaManchester United 0-0 Chelsea | Barclays Premier League |
| 28 | Sat 2 Jan 2016 | 82-1 v Swansea CityManchester United 2-1 Swansea City | Barclays Premier League |
| 29 | Sat 9 Jan 2016 | 81-0 v Sheffield UnitedManchester United 1-0 Sheffield United | Emirates FA Cup Third Round |
| 30 | Tue 12 Jan 2016 | 83-3 v Newcastle UnitedNewcastle United 3-3 Manchester United | Barclays Premier League |
| 31 | Sun 17 Jan 2016 | 81-0 v LiverpoolLiverpool 0-1 Manchester United | Barclays Premier League |
| 32 | Sat 23 Jan 2016 | 80-1 v SouthamptonManchester United 0-1 Southampton | Barclays Premier League |
| 33 | Fri 29 Jan 2016 | 83-1 v Derby CountyDerby County 1-3 Manchester United | Emirates FA Cup Fourth Round |
| 34 | Tue 2 Feb 2016 | 83-0 v Stoke CityManchester United 3-0 Stoke City | Barclays Premier League |
| 35 | Sun 7 Feb 2016 | 81-1 v ChelseaChelsea 1-1 Manchester United | Barclays Premier League |
| 36 | Sat 13 Feb 2016 | 81-2 v SunderlandSunderland 2-1 Manchester United | Barclays Premier League |
| 37 | Thu 18 Feb 2016 | 81-2 v FC MidtjyllandFC Midtjylland 2-1 Manchester United | Europa League Round of 32 |
| 38 | Mon 22 Feb 2016 | 83-0 v Shrewsbury TownShrewsbury Town 0-3 Manchester United | Emirates FA Cup Fifth Round |
| 39 | Thu 25 Feb 2016 | 85-1 v FC MidtjyllandManchester United 5-1 FC Midtjylland | Europa League Round of 32 |
| 40 | Sun 28 Feb 2016 | 83-2 v ArsenalManchester United 3-2 Arsenal | Barclays Premier League |
| 41 | Wed 2 Mar 2016 | 81-0 v WatfordManchester United 1-0 Watford | Barclays Premier League |
| 42 | Sun 6 Mar 2016 | 80-1 v West Bromwich AlbionWest Bromwich Albion 1-0 Manchester United | Barclays Premier League |
| 43 | Thu 10 Mar 2016 | 80-2 v LiverpoolLiverpool 2-0 Manchester United | Europa League Round of 16 |
| 44 | Thu 17 Mar 2016 | 271-1 v LiverpoolManchester United 1-1 Liverpool | Europa League Round of 16 |
| 45 | Sun 20 Mar 2016 | 81-0 v Manchester CityManchester City 0-1 Manchester United | Barclays Premier League |
| 46 | Sun 3 Apr 2016 | 351-0 v EvertonManchester United 1-0 Everton | Barclays Premier League |
| 47 | Sun 10 Apr 2016 | 80-3 v Tottenham HotspurTottenham Hotspur 3-0 Manchester United | Barclays Premier League |
| 48 | Sat 16 Apr 2016 | 81-0 v Aston VillaManchester United 1-0 Aston Villa | Barclays Premier League |
| 49 | Wed 20 Apr 2016 | 82-0 v Crystal PalaceManchester United 2-0 Crystal Palace | Barclays Premier League |
| 50 | Sun 1 May 2016 | 81-1 v Leicester CityManchester United 1-1 Leicester City | Barclays Premier League |
| 51 | Sat 7 May 2016 | 81-0 v Norwich CityNorwich City 0-1 Manchester United | Barclays Premier League |
| 52 | Tue 10 May 2016 | 82-3 v West Ham UnitedWest Ham United 3-2 Manchester United | Barclays Premier League |
| 53 | Tue 17 May 2016 | 83-1 v AFC BournemouthManchester United 3-1 AFC Bournemouth | Barclays Premier League |
| 54 | Sat 21 May 2016 | 82-1 v Crystal PalaceCrystal Palace 1-2 Manchester United | Emirates FA Cup Final |
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