| 1 | Sun 22 Aug 2021 | 141-1 v SouthamptonSouthampton 1-1 Manchester United | Premier League |
| 2 | Sat 11 Sep 2021 | 144-1 v Newcastle UnitedManchester United 4-1 Newcastle United | Premier League |
| 3 | Tue 14 Sep 2021 | 141-2 v Young BoysYoung Boys 2-1 Manchester United | UEFA Champions League Group F |
| 4 | Sun 19 Sep 2021 | 142-1 v West Ham UnitedWest Ham United 1-2 Manchester United | Premier League |
| 5 | Wed 22 Sep 2021 | 140-1 v West Ham UnitedManchester United 0-1 West Ham United | Carabao Cup Third Round |
| 6 | Wed 29 Sep 2021 | 142-1 v VillarrealManchester United 2-1 Villarreal | UEFA Champions League Group F |
| 7 | Sat 16 Oct 2021 | 142-4 v Leicester CityLeicester City 4-2 Manchester United | Premier League |
| 8 | Sat 30 Oct 2021 | 143-0 v Tottenham HotspurTottenham Hotspur 0-3 Manchester United | Premier League |
| 9 | Sat 20 Nov 2021 | 141-4 v WatfordWatford 4-1 Manchester United | Premier League |
| 10 | Sun 28 Nov 2021 | 141-1 v ChelseaChelsea 1-1 Manchester United | Premier League |
| 11 | Thu 2 Dec 2021 | 143-2 v ArsenalManchester United 3-2 Arsenal | Premier League |
| 12 | Wed 8 Dec 2021 | 141-1 v Young BoysManchester United 1-1 Young Boys | UEFA Champions League Group F |
| 13 | Mon 10 Jan 2022 | 141-0 v Aston VillaManchester United 1-0 Aston Villa | Emirates FA Cup Third Round |
| 14 | Sat 15 Jan 2022 | 142-2 v Aston VillaAston Villa 2-2 Manchester United | Premier League |
| 15 | Tue 8 Feb 2022 | 141-1 v BurnleyBurnley 1-1 Manchester United | Premier League |
| 16 | Sat 12 Feb 2022 | 14 1-1 v SouthamptonManchester United 1-1 Southampton | Premier League |
| 17 | Sun 20 Feb 2022 | 144-2 v Leeds UnitedLeeds United 2-4 Manchester United | Premier League |
| 18 | Wed 23 Feb 2022 | 141-1 v Atlético MadridAtlético Madrid 1-1 Manchester United | UEFA Champions League Round of 16 |
| 19 | Sun 6 Mar 2022 | 141-4 v Manchester CityManchester City 4-1 Manchester United | Premier League |
| 20 | Sat 16 Apr 2022 | 143-2 v Norwich CityManchester United 3-2 Norwich City | Premier League |
| 21 | Tue 19 Apr 2022 | 140-4 v LiverpoolLiverpool 4-0 Manchester United | Premier League |
| 22 | Sat 23 Apr 2022 | 141-3 v ArsenalArsenal 3-1 Manchester United | Premier League |
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