| 1 | Sat 14 Aug 2021 | 25-1 v Leeds UnitedManchester United 5-1 Leeds United | Premier League |
| 2 | Sun 22 Aug 2021 | 21-1 v SouthamptonSouthampton 1-1 Manchester United | Premier League |
| 3 | Tue 14 Sep 2021 | 21-2 v Young BoysYoung Boys 2-1 Manchester United | UEFA Champions League Group F |
| 4 | Wed 22 Sep 2021 | 20-1 v West Ham UnitedManchester United 0-1 West Ham United | Carabao Cup Third Round |
| 5 | Sat 25 Sep 2021 | 20-1 v Aston VillaManchester United 0-1 Aston Villa | Premier League |
| 6 | Wed 29 Sep 2021 | 22-1 v VillarrealManchester United 2-1 Villarreal | UEFA Champions League Group F |
| 7 | Sat 2 Oct 2021 | 21-1 v EvertonManchester United 1-1 Everton | Premier League |
| 8 | Sat 16 Oct 2021 | 2 2-4 v Leicester CityLeicester City 4-2 Manchester United | Premier League |
| 9 | Wed 20 Oct 2021 | 23-2 v AtalantaManchester United 3-2 Atalanta | UEFA Champions League Group F |
| 10 | Sun 24 Oct 2021 | 20-5 v LiverpoolManchester United 0-5 Liverpool | Premier League |
| 11 | Sat 30 Oct 2021 | 23-0 v Tottenham HotspurTottenham Hotspur 0-3 Manchester United | Premier League |
| 12 | Sat 6 Nov 2021 | 20-2 v Manchester CityManchester United 0-2 Manchester City | Premier League |
| 13 | Sat 20 Nov 2021 | 21-4 v WatfordWatford 4-1 Manchester United | Premier League |
| 14 | Tue 23 Nov 2021 | 22-0 v VillarrealVillarreal 0-2 Manchester United | UEFA Champions League Group F |
| 15 | Sun 28 Nov 2021 | 21-1 v ChelseaChelsea 1-1 Manchester United | Premier League |
| 16 | Thu 2 Dec 2021 | 23-2 v ArsenalManchester United 3-2 Arsenal | Premier League |
| 17 | Sun 5 Dec 2021 | 2 1-0 v Crystal PalaceManchester United 1-0 Crystal Palace | Premier League |
| 18 | Sat 11 Dec 2021 | 21-0 v Norwich CityNorwich City 0-1 Manchester United | Premier League |
| 19 | Mon 10 Jan 2022 | 21-0 v Aston VillaManchester United 1-0 Aston Villa | Emirates FA Cup Third Round |
| 20 | Sat 15 Jan 2022 | 22-2 v Aston VillaAston Villa 2-2 Manchester United | Premier League |
| 21 | Wed 19 Jan 2022 | 23-1 v BrentfordBrentford 1-3 Manchester United | Premier League |
| 22 | Sun 20 Feb 2022 | 24-2 v Leeds UnitedLeeds United 2-4 Manchester United | Premier League |
| 23 | Wed 23 Feb 2022 | 2 1-1 v Atlético MadridAtlético Madrid 1-1 Manchester United | UEFA Champions League Round of 16 |
| 24 | Sat 26 Feb 2022 | 20-0 v WatfordManchester United 0-0 Watford | Premier League |
| 25 | Sun 6 Mar 2022 | 21-4 v Manchester CityManchester City 4-1 Manchester United | Premier League |
| 26 | Sat 12 Mar 2022 | 23-2 v Tottenham HotspurManchester United 3-2 Tottenham Hotspur | Premier League |
| 27 | Sat 9 Apr 2022 | 20-1 v EvertonEverton 1-0 Manchester United | Premier League |
| 28 | Sat 16 Apr 2022 | 23-2 v Norwich CityManchester United 3-2 Norwich City | Premier League |
| 29 | Tue 19 Apr 2022 | 20-4 v LiverpoolLiverpool 4-0 Manchester United | Premier League |
| 30 | Sat 23 Apr 2022 | 2 1-3 v ArsenalArsenal 3-1 Manchester United | Premier League |
| 31 | Thu 28 Apr 2022 | 21-1 v ChelseaManchester United 1-1 Chelsea | Premier League |
| 32 | Mon 2 May 2022 | 23-0 v BrentfordManchester United 3-0 Brentford | Premier League |
| 33 | Sat 7 May 2022 | 20-4 v Brighton & Hove AlbionBrighton & Hove Albion 4-0 Manchester United | Premier League |
| 34 | Sun 22 May 2022 | 2 0-1 v Crystal PalaceCrystal Palace 1-0 Manchester United | Premier League |
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