| 1 | 14/8/2021 | 15-1 v Leeds UnitedManchester United 5-1 Leeds United | Premier League |
| 2 | 22/8/2021 | 11-1 v SouthamptonSouthampton 1-1 Manchester United | Premier League |
| 3 | 29/8/2021 | 11-0 v Wolverhampton WanderersWolverhampton Wanderers 0-1 Manchester United | Premier League |
| 4 | 11/9/2021 | 14-1 v Newcastle UnitedManchester United 4-1 Newcastle United | Premier League |
| 5 | 14/9/2021 | 11-2 v Young BoysYoung Boys 2-1 Manchester United | UEFA Champions League Group F |
| 6 | 19/9/2021 | 12-1 v West Ham UnitedWest Ham United 1-2 Manchester United | Premier League |
| 7 | 25/9/2021 | 10-1 v Aston VillaManchester United 0-1 Aston Villa | Premier League |
| 8 | 29/9/2021 | 12-1 v VillarrealManchester United 2-1 Villarreal | UEFA Champions League Group F |
| 9 | 2/10/2021 | 11-1 v EvertonManchester United 1-1 Everton | Premier League |
| 10 | 16/10/2021 | 12-4 v Leicester CityLeicester City 4-2 Manchester United | Premier League |
| 11 | 20/10/2021 | 13-2 v AtalantaManchester United 3-2 Atalanta | UEFA Champions League Group F |
| 12 | 24/10/2021 | 10-5 v LiverpoolManchester United 0-5 Liverpool | Premier League |
| 13 | 30/10/2021 | 13-0 v Tottenham HotspurTottenham Hotspur 0-3 Manchester United | Premier League |
| 14 | 2/11/2021 | 12-2 v AtalantaAtalanta 2-2 Manchester United | UEFA Champions League Group F |
| 15 | 6/11/2021 | 10-2 v Manchester CityManchester United 0-2 Manchester City | Premier League |
| 16 | 20/11/2021 | 11-4 v WatfordWatford 4-1 Manchester United | Premier League |
| 17 | 23/11/2021 | 12-0 v VillarrealVillarreal 0-2 Manchester United | UEFA Champions League Group F |
| 18 | 28/11/2021 | 11-1 v ChelseaChelsea 1-1 Manchester United | Premier League |
| 19 | 2/12/2021 | 13-2 v ArsenalManchester United 3-2 Arsenal | Premier League |
| 20 | 5/12/2021 | 11-0 v Crystal PalaceManchester United 1-0 Crystal Palace | Premier League |
| 21 | 11/12/2021 | 11-0 v Norwich CityNorwich City 0-1 Manchester United | Premier League |
| 22 | 27/12/2021 | 11-1 v Newcastle UnitedNewcastle United 1-1 Manchester United | Premier League |
| 23 | 30/12/2021 | 13-1 v BurnleyManchester United 3-1 Burnley | Premier League |
| 24 | 3/1/2022 | 10-1 v Wolverhampton WanderersManchester United 0-1 Wolverhampton Wanderers | Premier League |
| 25 | 10/1/2022 | 11-0 v Aston VillaManchester United 1-0 Aston Villa | Emirates FA Cup Third Round |
| 26 | 15/1/2022 | 12-2 v Aston VillaAston Villa 2-2 Manchester United | Premier League |
| 27 | 19/1/2022 | 13-1 v BrentfordBrentford 1-3 Manchester United | Premier League |
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