| 1 | Sat 7 Aug 2021 | 11 2-1 v Bristol RoversMansfield Town 2-1 Bristol Rovers | Sky Bet League Two |
| 2 | Sat 14 Aug 2021 | 112-1 v Newport CountyMansfield Town 2-1 Newport County | Sky Bet League Two |
| 3 | Tue 17 Aug 2021 | 111-1 v Colchester UnitedColchester United 1-1 Mansfield Town | Sky Bet League Two |
| 4 | Sat 21 Aug 2021 | 112-3 v Bradford CityMansfield Town 2-3 Bradford City | Sky Bet League Two |
| 5 | Sat 28 Aug 2021 | 110-1 v Swindon TownSwindon Town 1-0 Mansfield Town | Sky Bet League Two |
| 6 | Sat 4 Sep 2021 | 111-3 v Harrogate TownMansfield Town 1-3 Harrogate Town | Sky Bet League Two |
| 7 | Sat 11 Sep 2021 | 111-3 v WalsallWalsall 3-1 Mansfield Town | Sky Bet League Two |
| 8 | Sat 18 Sep 2021 | 11 1-1 v RochdaleMansfield Town 1-1 Rochdale | Sky Bet League Two |
| 9 | Sat 25 Sep 2021 | 110-0 v Leyton OrientLeyton Orient 0-0 Mansfield Town | Sky Bet League Two |
| 10 | Sat 2 Oct 2021 | 110-1 v BarrowMansfield Town 0-1 Barrow | Sky Bet League Two |
| 11 | Tue 5 Oct 2021 | 111-2 v Sheffield WednesdayMansfield Town 1-2 Sheffield Wednesday | Papa John’s Trophy |
| 12 | Sat 9 Oct 2021 | 110-0 v Oldham AthleticMansfield Town 0-0 Oldham Athletic | Sky Bet League Two |
| 13 | Sat 16 Oct 2021 | 110-2 v Northampton TownNorthampton Town 2-0 Mansfield Town | Sky Bet League Two |
| 14 | Tue 19 Oct 2021 | 111-1 v Port ValeMansfield Town 1-1 Port Vale | Sky Bet League Two |
| 15 | Sat 23 Oct 2021 | 111-2 v Exeter CityExeter City 2-1 Mansfield Town | Sky Bet League Two |
| 16 | Sat 30 Oct 2021 | 112-0 v Tranmere RoversMansfield Town 2-0 Tranmere Rovers | Sky Bet League Two |
| 17 | Sat 8 Jan 2022 | 112-3 v MiddlesbroughMansfield Town 2-3 Middlesbrough | Emirates FA Cup Third Round |
| 18 | Sat 15 Jan 2022 | 112-0 v WalsallMansfield Town 2-0 Walsall | Sky Bet League Two |
| 19 | Sat 12 Feb 2022 | 110-0 v Bristol RoversBristol Rovers 0-0 Mansfield Town | Sky Bet League Two |
| 20 | Tue 15 Mar 2022 | 111-3 v Port ValePort Vale 3-1 Mansfield Town | Sky Bet League Two |
| 21 | Tue 5 Apr 2022 | 110-1 v Forest Green RoversForest Green Rovers 1-0 Mansfield Town | Sky Bet League Two |
| 22 | Sat 9 Apr 2022 | 114-0 v Scunthorpe UnitedScunthorpe United 0-4 Mansfield Town | Sky Bet League Two |
| 23 | Fri 15 Apr 2022 | 112-3 v Sutton UnitedMansfield Town 2-3 Sutton United | Sky Bet League Two |
| 24 | Mon 18 Apr 2022 | 110-1 v Carlisle UnitedCarlisle United 1-0 Mansfield Town | Sky Bet League Two |
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