| 1 | Sat 21 Nov 2020 | 161-3 v Hull CityMilton Keynes Dons 1-3 Hull City | Sky Bet League One |
| 2 | Tue 24 Nov 2020 | 162-2 v Shrewsbury TownMilton Keynes Dons 2-2 Shrewsbury Town | Sky Bet League One |
| 3 | Wed 2 Dec 2020 | 161-0 v Charlton AthleticCharlton Athletic 0-1 Milton Keynes Dons | Sky Bet League One |
| 4 | Sat 5 Dec 2020 | 161-2 v Accrington StanleyAccrington Stanley 2-1 Milton Keynes Dons | Sky Bet League One |
| 5 | Sat 12 Dec 2020 | 161-1 v Burton AlbionMilton Keynes Dons 1-1 Burton Albion | Sky Bet League One |
| 6 | Tue 15 Dec 2020 | 161-1 v Peterborough UnitedMilton Keynes Dons 1-1 Peterborough United | Sky Bet League One |
| 7 | Sat 19 Dec 2020 | 160-1 v Plymouth ArgylePlymouth Argyle 1-0 Milton Keynes Dons | Sky Bet League One |
| 8 | Sat 26 Dec 2020 | 162-0 v Bristol RoversMilton Keynes Dons 2-0 Bristol Rovers | Sky Bet League One |
| 9 | Tue 29 Dec 2020 | 164-1 v Swindon TownSwindon Town 1-4 Milton Keynes Dons | Sky Bet League One |
| 10 | Tue 12 Jan 2021 | 162-0 v Northampton TownNorthampton Town 0-2 Milton Keynes Dons | Papa John’s Trophy Third Round |
| 11 | Sat 16 Jan 2021 | 160-3 v Peterborough UnitedPeterborough United 3-0 Milton Keynes Dons | Sky Bet League One |
| 12 | Sat 6 Feb 2021 | 16 2-2 v SunderlandMilton Keynes Dons 2-2 Sunderland | Sky Bet League One |
| 13 | Tue 9 Feb 2021 | 164-1 v RochdaleRochdale 1-4 Milton Keynes Dons | Sky Bet League One |
| 14 | Sat 13 Feb 2021 | 161-0 v Hull CityHull City 0-1 Milton Keynes Dons | Sky Bet League One |
| 15 | Sat 20 Feb 2021 | 164-3 v Northampton TownMilton Keynes Dons 4-3 Northampton Town | Sky Bet League One |
| 16 | Tue 23 Feb 2021 | 162-4 v Shrewsbury TownShrewsbury Town 4-2 Milton Keynes Dons | Sky Bet League One |
| 17 | Sat 27 Feb 2021 | 161-1 v Oxford UnitedMilton Keynes Dons 1-1 Oxford United | Sky Bet League One |
| 18 | Tue 2 Mar 2021 | 162-3 v GillinghamGillingham 3-2 Milton Keynes Dons | Sky Bet League One |
| 19 | Sat 6 Mar 2021 | 160-3 v Wigan AthleticWigan Athletic 3-0 Milton Keynes Dons | Sky Bet League One |
| 20 | Tue 9 Mar 2021 | 160-1 v BlackpoolMilton Keynes Dons 0-1 Blackpool | Sky Bet League One |
| 21 | Sat 13 Mar 2021 | 163-2 v Accrington StanleyMilton Keynes Dons 3-2 Accrington Stanley | Sky Bet League One |
| 22 | Tue 16 Mar 2021 | 162-1 v Plymouth ArgyleMilton Keynes Dons 2-1 Plymouth Argyle | Sky Bet League One |
| 23 | Sat 20 Mar 2021 | 162-1 v Burton AlbionBurton Albion 1-2 Milton Keynes Dons | Sky Bet League One |
| 24 | Sat 27 Mar 2021 | 161-0 v Doncaster RoversMilton Keynes Dons 1-0 Doncaster Rovers | Sky Bet League One |
| 25 | Mon 5 Apr 2021 | 160-2 v Crewe AlexandraMilton Keynes Dons 0-2 Crewe Alexandra | Sky Bet League One |
| 26 | Sat 10 Apr 2021 | 160-0 v Ipswich TownIpswich Town 0-0 Milton Keynes Dons | Sky Bet League One |
| 27 | Tue 13 Apr 2021 | 160-4 v Lincoln CityLincoln City 4-0 Milton Keynes Dons | Sky Bet League One |
| 28 | Sat 17 Apr 2021 | 161-0 v PortsmouthMilton Keynes Dons 1-0 Portsmouth | Sky Bet League One |
| 29 | Tue 20 Apr 2021 | 162-0 v Bristol RoversBristol Rovers 0-2 Milton Keynes Dons | Sky Bet League One |
| 30 | Sat 24 Apr 2021 | 165-0 v Swindon TownMilton Keynes Dons 5-0 Swindon Town | Sky Bet League One |
| 31 | Sat 1 May 2021 | 161-1 v Fleetwood TownFleetwood Town 1-1 Milton Keynes Dons | Sky Bet League One |
| 32 | Sun 9 May 2021 | 160-3 v RochdaleMilton Keynes Dons 0-3 Rochdale | Sky Bet League One |
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