| 1 | Sun 8 Aug 2021 | 22-3 v MarseilleMontpellier 2-3 Marseille | French Ligue 1 |
| 2 | Sun 15 Aug 2021 | 23-3 v ReimsReims 3-3 Montpellier | French Ligue 1 |
| 3 | Sun 22 Aug 2021 | 23-1 v LorientMontpellier 3-1 Lorient | French Ligue 1 |
| 4 | Sun 29 Aug 2021 | 21-2 v LilleLille 2-1 Montpellier | French Ligue 1 |
| 5 | Sun 12 Sep 2021 | 22-0 v Saint ÉtienneMontpellier 2-0 Saint Étienne | French Ligue 1 |
| 6 | Wed 22 Sep 2021 | 23-3 v BordeauxMontpellier 3-3 Bordeaux | French Ligue 1 |
| 7 | Sat 2 Oct 2021 | 21-1 v StrasbourgMontpellier 1-1 Strasbourg | French Ligue 1 |
| 8 | Sun 24 Oct 2021 | 21-3 v MonacoMonaco 3-1 Montpellier | French Ligue 1 |
| 9 | Sun 31 Oct 2021 | 22-0 v NantesMontpellier 2-0 Nantes | French Ligue 1 |
| 10 | Sun 7 Nov 2021 | 21-0 v NiceNice 0-1 Montpellier | French Ligue 1 |
| 11 | Sun 28 Nov 2021 | 20-1 v LyonMontpellier 0-1 Lyon | French Ligue 1 |
| 12 | Wed 1 Dec 2021 | 23-1 v MetzMetz 1-3 Montpellier | French Ligue 1 |
| 13 | Sat 11 Dec 2021 | 24-0 v BrestBrest 0-4 Montpellier | French Ligue 1 |
| 14 | Wed 22 Dec 2021 | 24-1 v AngersMontpellier 4-1 Angers | French Ligue 1 |
| 15 | Sun 16 Jan 2022 | 21-3 v StrasbourgStrasbourg 3-1 Montpellier | French Ligue 1 |
| 16 | Sun 23 Jan 2022 | 23-2 v MonacoMontpellier 3-2 Monaco | French Ligue 1 |
| 17 | Sat 5 Feb 2022 | 21-3 v Saint ÉtienneSaint Étienne 3-1 Montpellier | French Ligue 1 |
| 18 | Sat 12 Feb 2022 | 20-1 v LilleMontpellier 0-1 Lille | French Ligue 1 |
| 19 | Sun 20 Feb 2022 | 2 1-0 v LorientLorient 0-1 Montpellier | French Ligue 1 |
| 20 | Fri 25 Feb 2022 | 22-4 v RennesMontpellier 2-4 Rennes | French Ligue 1 |
| 21 | Sat 12 Mar 2022 | 20-0 v NiceMontpellier 0-0 Nice | French Ligue 1 |
| 22 | Sun 20 Mar 2022 | 22-0 v BordeauxBordeaux 0-2 Montpellier | French Ligue 1 |
| 23 | Sun 3 Apr 2022 | 21-2 v BrestMontpellier 1-2 Brest | French Ligue 1 |
| 24 | Sun 10 Apr 2022 | 20-2 v MarseilleMarseille 2-0 Montpellier | French Ligue 1 |
| 25 | Sun 17 Apr 2022 | 20-0 v ReimsMontpellier 0-0 Reims | French Ligue 1 |
| 26 | Wed 20 Apr 2022 | 20-2 v LensLens 2-0 Montpellier | French Ligue 1 |
| 27 | Sat 23 Apr 2022 | 22-5 v LyonLyon 5-2 Montpellier | French Ligue 1 |
| 28 | Sun 1 May 2022 | 22-2 v MetzMontpellier 2-2 Metz | French Ligue 1 |
| 29 | Sun 8 May 2022 | 2 1-2 v ClermontClermont 2-1 Montpellier | French Ligue 1 |
| 30 | Sat 14 May 2022 | 2 0-4 v Paris St GermainMontpellier 0-4 Paris St Germain | French Ligue 1 |
| 31 | Sat 21 May 2022 | 20-2 v AngersAngers 2-0 Montpellier | French Ligue 1 |
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