| 1 | Sun 8 Aug 2021 | 62-3 v MarseilleMontpellier 2-3 Marseille | French Ligue 1 |
| 2 | Sun 15 Aug 2021 | 63-3 v ReimsReims 3-3 Montpellier | French Ligue 1 |
| 3 | Sun 22 Aug 2021 | 63-1 v LorientMontpellier 3-1 Lorient | French Ligue 1 |
| 4 | Sun 29 Aug 2021 | 6 1-2 v LilleLille 2-1 Montpellier | French Ligue 1 |
| 5 | Wed 22 Sep 2021 | 63-3 v BordeauxMontpellier 3-3 Bordeaux | French Ligue 1 |
| 6 | Sat 25 Sep 2021 | 60-2 v Paris St GermainParis St Germain 2-0 Montpellier | French Ligue 1 |
| 7 | Sun 17 Oct 2021 | 61-0 v LensMontpellier 1-0 Lens | French Ligue 1 |
| 8 | Sun 24 Oct 2021 | 61-3 v MonacoMonaco 3-1 Montpellier | French Ligue 1 |
| 9 | Sun 31 Oct 2021 | 62-0 v NantesMontpellier 2-0 Nantes | French Ligue 1 |
| 10 | Sun 7 Nov 2021 | 61-0 v NiceNice 0-1 Montpellier | French Ligue 1 |
| 11 | Sat 20 Nov 2021 | 60-2 v RennesRennes 2-0 Montpellier | French Ligue 1 |
| 12 | Sun 28 Nov 2021 | 60-1 v LyonMontpellier 0-1 Lyon | French Ligue 1 |
| 13 | Wed 1 Dec 2021 | 63-1 v MetzMetz 1-3 Montpellier | French Ligue 1 |
| 14 | Sat 11 Dec 2021 | 64-0 v BrestBrest 0-4 Montpellier | French Ligue 1 |
| 15 | Wed 22 Dec 2021 | 6 4-1 v AngersMontpellier 4-1 Angers | French Ligue 1 |
| 16 | Sun 16 Jan 2022 | 61-3 v StrasbourgStrasbourg 3-1 Montpellier | French Ligue 1 |
| 17 | Sun 23 Jan 2022 | 6 3-2 v MonacoMontpellier 3-2 Monaco | French Ligue 1 |
| 18 | Sat 12 Feb 2022 | 60-1 v LilleMontpellier 0-1 Lille | French Ligue 1 |
| 19 | Sun 20 Feb 2022 | 61-0 v LorientLorient 0-1 Montpellier | French Ligue 1 |
| 20 | Fri 25 Feb 2022 | 62-4 v RennesMontpellier 2-4 Rennes | French Ligue 1 |
| 21 | Sun 6 Mar 2022 | 60-2 v NantesNantes 2-0 Montpellier | French Ligue 1 |
| 22 | Sat 12 Mar 2022 | 60-0 v NiceMontpellier 0-0 Nice | French Ligue 1 |
| 23 | Sun 20 Mar 2022 | 62-0 v BordeauxBordeaux 0-2 Montpellier | French Ligue 1 |
| 24 | Sun 3 Apr 2022 | 61-2 v BrestMontpellier 1-2 Brest | French Ligue 1 |
| 25 | Sun 10 Apr 2022 | 60-2 v MarseilleMarseille 2-0 Montpellier | French Ligue 1 |
| 26 | Sat 14 May 2022 | 60-4 v Paris St GermainMontpellier 0-4 Paris St Germain | French Ligue 1 |
| 27 | Sat 21 May 2022 | 60-2 v AngersAngers 2-0 Montpellier | French Ligue 1 |
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