| 1 | Sat 14 Aug 2021 | 260-5 v AjaxAjax 5-0 NEC Nijmegen | Dutch Eredivisie |
| 2 | Fri 20 Aug 2021 | 262-0 v PEC ZwolleNEC Nijmegen 2-0 PEC Zwolle | Dutch Eredivisie |
| 3 | Sun 29 Aug 2021 | 261-0 v Heracles AlmeloHeracles Almelo 0-1 NEC Nijmegen | Dutch Eredivisie |
| 4 | Sun 12 Sep 2021 | 260-0 v Willem IINEC Nijmegen 0-0 Willem II | Dutch Eredivisie |
| 5 | Fri 17 Sep 2021 | 261-1 v Sparta RotterdamSparta Rotterdam 1-1 NEC Nijmegen | Dutch Eredivisie |
| 6 | Wed 22 Sep 2021 | 260-3 v FC UtrechtNEC Nijmegen 0-3 FC Utrecht | Dutch Eredivisie |
| 7 | Sat 25 Sep 2021 | 263-5 v FeyenoordFeyenoord 5-3 NEC Nijmegen | Dutch Eredivisie |
| 8 | Sat 2 Oct 2021 | 26 3-1 v Fortuna SittardFortuna Sittard 1-3 NEC Nijmegen | Dutch Eredivisie |
| 9 | Sun 17 Oct 2021 | 260-1 v VitesseNEC Nijmegen 0-1 Vitesse | Dutch Eredivisie |
| 10 | Sun 24 Oct 2021 | 26 2-1 v FC TwenteFC Twente 1-2 NEC Nijmegen | Dutch Eredivisie |
| 11 | Sun 31 Oct 2021 | 263-0 v FC GroningenNEC Nijmegen 3-0 FC Groningen | Dutch Eredivisie |
| 12 | Sat 6 Nov 2021 | 261-1 v sc HeerenveenNEC Nijmegen 1-1 sc Heerenveen | Dutch Eredivisie |
| 13 | Sat 20 Nov 2021 | 261-1 v AZ AlkmaarAZ Alkmaar 1-1 NEC Nijmegen | Dutch Eredivisie |
| 14 | Sun 5 Dec 2021 | 26 1-2 v RKC WaalwijkRKC Waalwijk 2-1 NEC Nijmegen | Dutch Eredivisie |
| 15 | Sun 12 Dec 2021 | 261-2 v PSV EindhovenNEC Nijmegen 1-2 PSV Eindhoven | Dutch Eredivisie |
| 16 | Sun 19 Dec 2021 | 262-0 v Go Ahead EaglesGo Ahead Eagles 0-2 NEC Nijmegen | Dutch Eredivisie |
| 17 | Wed 22 Dec 2021 | 261-0 v Willem IIWillem II 0-1 NEC Nijmegen | Dutch Eredivisie |
| 18 | Sat 15 Jan 2022 | 260-0 v Heracles AlmeloNEC Nijmegen 0-0 Heracles Almelo | Dutch Eredivisie |
| 19 | Sun 23 Jan 2022 | 261-4 v FeyenoordNEC Nijmegen 1-4 Feyenoord | Dutch Eredivisie |
| 20 | Sat 5 Feb 2022 | 261-1 v PEC ZwollePEC Zwolle 1-1 NEC Nijmegen | Dutch Eredivisie |
| 21 | Sun 13 Feb 2022 | 261-0 v sc Heerenveensc Heerenveen 0-1 NEC Nijmegen | Dutch Eredivisie |
| 22 | Sat 19 Feb 2022 | 26 1-1 v RKC WaalwijkNEC Nijmegen 1-1 RKC Waalwijk | Dutch Eredivisie |
| 23 | Sun 27 Feb 2022 | 261-4 v VitesseVitesse 4-1 NEC Nijmegen | Dutch Eredivisie |
| 24 | Sun 6 Mar 2022 | 261-3 v AZ AlkmaarNEC Nijmegen 1-3 AZ Alkmaar | Dutch Eredivisie |
| 25 | Sat 12 Mar 2022 | 263-4 v FC GroningenFC Groningen 4-3 NEC Nijmegen | Dutch Eredivisie |
| 26 | Sat 19 Mar 2022 | 260-0 v Sparta RotterdamNEC Nijmegen 0-0 Sparta Rotterdam | Dutch Eredivisie |
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