| 1 | Sat 7 Aug 2021 | 2 1-0 v Oldham AthleticOldham Athletic 0-1 Newport County | Sky Bet League Two |
| 2 | Sat 14 Aug 2021 | 21-2 v Mansfield TownMansfield Town 2-1 Newport County | Sky Bet League Two |
| 3 | Sat 21 Aug 2021 | 21-0 v Tranmere RoversTranmere Rovers 0-1 Newport County | Sky Bet League Two |
| 4 | Sat 28 Aug 2021 | 2 0-3 v Salford CitySalford City 3-0 Newport County | Sky Bet League Two |
| 5 | Sat 4 Sep 2021 | 22-2 v Leyton OrientNewport County 2-2 Leyton Orient | Sky Bet League Two |
| 6 | Fri 10 Sep 2021 | 22-2 v Harrogate TownHarrogate Town 2-2 Newport County | Sky Bet League Two |
| 7 | Tue 14 Sep 2021 | 20-1 v Northampton TownNewport County 0-1 Northampton Town | Sky Bet League Two |
| 8 | Sat 18 Sep 2021 | 22-1 v WalsallNewport County 2-1 Walsall | Sky Bet League Two |
| 9 | Fri 24 Sep 2021 | 21-2 v BarrowBarrow 2-1 Newport County | Sky Bet League Two |
| 10 | Sat 2 Oct 2021 | 23-0 v Scunthorpe UnitedNewport County 3-0 Scunthorpe United | Sky Bet League Two |
| 11 | Sat 9 Oct 2021 | 20-0 v Bradford CityNewport County 0-0 Bradford City | Sky Bet League Two |
| 12 | Sat 16 Oct 2021 | 22-2 v Exeter CityExeter City 2-2 Newport County | Sky Bet League Two |
| 13 | Tue 19 Oct 2021 | 22-2 v Carlisle UnitedNewport County 2-2 Carlisle United | Sky Bet League Two |
| 14 | Sat 23 Oct 2021 | 23-1 v Bristol RoversBristol Rovers 1-3 Newport County | Sky Bet League Two |
| 15 | Sat 30 Oct 2021 | 25-0 v StevenageNewport County 5-0 Stevenage | Sky Bet League Two |
| 16 | Sat 6 Nov 2021 | 20-1 v MorecambeMorecambe 1-0 Newport County | Emirates FA Cup First Round |
| 17 | Fri 12 Nov 2021 | 22-1 v Hartlepool UnitedHartlepool United 1-2 Newport County | Sky Bet League Two |
| 18 | Sat 20 Nov 2021 | 21-2 v Swindon TownNewport County 1-2 Swindon Town | Sky Bet League Two |
| 19 | Tue 23 Nov 2021 | 2 1-1 v Crawley TownCrawley Town 1-1 Newport County | Sky Bet League Two |
| 20 | Fri 26 Nov 2021 | 21-1 v Colchester UnitedColchester United 1-1 Newport County | Sky Bet League Two |
| 21 | Tue 7 Dec 2021 | 23-2 v Sutton UnitedNewport County 3-2 Sutton United | Sky Bet League Two |
| 22 | Sat 11 Dec 2021 | 22-1 v Port ValeNewport County 2-1 Port Vale | Sky Bet League Two |
| 23 | Sat 18 Dec 2021 | 2 0-3 v RochdaleRochdale 3-0 Newport County | Sky Bet League Two |
| 24 | Sat 1 Jan 2022 | 23-3 v WalsallWalsall 3-3 Newport County | Sky Bet League Two |
| 25 | Sat 8 Jan 2022 | 2 0-2 v Salford CityNewport County 0-2 Salford City | Sky Bet League Two |
| 26 | Sat 15 Jan 2022 | 2 4-0 v Harrogate TownNewport County 4-0 Harrogate Town | Sky Bet League Two |
| 27 | Sat 22 Jan 2022 | 21-0 v Scunthorpe UnitedScunthorpe United 0-1 Newport County | Sky Bet League Two |
| 28 | Tue 25 Jan 2022 | 21-0 v Leyton OrientLeyton Orient 0-1 Newport County | Sky Bet League Two |
| 29 | Sat 29 Jan 2022 | 22-1 v BarrowNewport County 2-1 Barrow | Sky Bet League Two |
| 30 | Sat 5 Feb 2022 | 20-2 v Forest Green RoversForest Green Rovers 2-0 Newport County | Sky Bet League Two |
| 31 | Tue 8 Feb 2022 | 2 0-1 v Northampton TownNorthampton Town 1-0 Newport County | Sky Bet League Two |
| 32 | Sat 12 Feb 2022 | 23-3 v Oldham AthleticNewport County 3-3 Oldham Athletic | Sky Bet League Two |
| 33 | Sat 19 Feb 2022 | 21-1 v Mansfield TownNewport County 1-1 Mansfield Town | Sky Bet League Two |
| 34 | Sat 26 Feb 2022 | 24-2 v Tranmere RoversNewport County 4-2 Tranmere Rovers | Sky Bet League Two |
| 35 | Tue 1 Mar 2022 | 21-1 v Forest Green RoversNewport County 1-1 Forest Green Rovers | Sky Bet League Two |
| 36 | Sat 5 Mar 2022 | 21-0 v Bristol RoversNewport County 1-0 Bristol Rovers | Sky Bet League Two |
| 37 | Sat 12 Mar 2022 | 22-0 v StevenageStevenage 0-2 Newport County | Sky Bet League Two |
| 38 | Tue 15 Mar 2022 | 22-1 v Carlisle UnitedCarlisle United 1-2 Newport County | Sky Bet League Two |
| 39 | Fri 18 Mar 2022 | 22-3 v Hartlepool UnitedNewport County 2-3 Hartlepool United | Sky Bet League Two |
| 40 | Sat 26 Mar 2022 | 20-0 v Bradford CityBradford City 0-0 Newport County | Sky Bet League Two |
| 41 | Sat 2 Apr 2022 | 2 0-1 v Exeter CityNewport County 0-1 Exeter City | Sky Bet League Two |
| 42 | Sat 9 Apr 2022 | 21-0 v Swindon TownSwindon Town 0-1 Newport County | Sky Bet League Two |
| 43 | Fri 15 Apr 2022 | 21-2 v Crawley TownNewport County 1-2 Crawley Town | Sky Bet League Two |
| 44 | Mon 18 Apr 2022 | 2 0-1 v Sutton UnitedSutton United 1-0 Newport County | Sky Bet League Two |
| 45 | Fri 22 Apr 2022 | 21-2 v Colchester UnitedNewport County 1-2 Colchester United | Sky Bet League Two |
| 46 | Mon 2 May 2022 | 22-1 v Port ValePort Vale 1-2 Newport County | Sky Bet League Two |
| 47 | Sat 7 May 2022 | 20-2 v RochdaleNewport County 0-2 Rochdale | Sky Bet League Two |
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