| 1 | Sun 17 Oct 2021 | 32-1 v VillarrealVillarreal 1-2 Osasuna | Spanish La Liga |
| 2 | Fri 22 Oct 2021 | 31-1 v GranadaOsasuna 1-1 Granada | Spanish La Liga |
| 3 | Wed 27 Oct 2021 | 30-0 v Real MadridReal Madrid 0-0 Osasuna | Spanish La Liga |
| 4 | Sat 20 Nov 2021 | 30-1 v Atlético MadridAtlético Madrid 1-0 Osasuna | Spanish La Liga |
| 5 | Sun 5 Dec 2021 | 30-0 v LevanteLevante 0-0 Osasuna | Spanish La Liga |
| 6 | Sun 12 Dec 2021 | 3 2-2 v BarcelonaOsasuna 2-2 Barcelona | Spanish La Liga |
| 7 | Sun 19 Dec 2021 | 30-1 v GetafeGetafe 1-0 Osasuna | Spanish La Liga |
| 8 | Mon 3 Jan 2022 | 31-3 v Athletic BilbaoOsasuna 1-3 Athletic Bilbao | Spanish La Liga |
| 9 | Sun 9 Jan 2022 | 3 2-0 v CádizOsasuna 2-0 Cádiz | Spanish La Liga |
| 10 | Wed 19 Jan 2022 | 30-2 v Celta VigoCelta Vigo 2-0 Osasuna | Spanish La Liga |
| 11 | Sun 23 Jan 2022 | 32-0 v GranadaGranada 0-2 Osasuna | Spanish La Liga |
| 12 | Sat 5 Feb 2022 | 30-0 v SevillaOsasuna 0-0 Sevilla | Spanish La Liga |
| 13 | Sat 12 Feb 2022 | 33-0 v Rayo VallecanoRayo Vallecano 0-3 Osasuna | Spanish La Liga |
| 14 | Sat 19 Feb 2022 | 30-3 v Atlético MadridOsasuna 0-3 Atlético Madrid | Spanish La Liga |
| 15 | Sun 27 Feb 2022 | 3 0-1 v Real SociedadReal Sociedad 1-0 Osasuna | Spanish La Liga |
| 16 | Sat 5 Mar 2022 | 31-0 v VillarrealOsasuna 1-0 Villarreal | Spanish La Liga |
| 17 | Sun 13 Mar 2022 | 30-4 v BarcelonaBarcelona 4-0 Osasuna | Spanish La Liga |
| 18 | Sat 19 Mar 2022 | 33-1 v LevanteOsasuna 3-1 Levante | Spanish La Liga |
| 19 | Sun 3 Apr 2022 | 31-4 v Real BetisReal Betis 4-1 Osasuna | Spanish La Liga |
| 20 | Sun 1 May 2022 | 3 1-1 v ElcheElche 1-1 Osasuna | Spanish La Liga |
| 21 | Sun 8 May 2022 | 31-1 v EspanyolEspanyol 1-1 Osasuna | Spanish La Liga |
| 22 | Wed 11 May 2022 | 31-1 v GetafeOsasuna 1-1 Getafe | Spanish La Liga |
| 23 | Sun 15 May 2022 | 30-2 v Athletic BilbaoAthletic Bilbao 2-0 Osasuna | Spanish La Liga |
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