| 1 | Wed 11 Jul 2018 | 162-0 v UCDUCD 0-2 Oxford United | Friendly |
| 2 | Fri 27 Jul 2018 | 40-1 v Milton Keynes DonsMilton Keynes Dons 1-0 Oxford United | Friendly |
| 3 | Sat 4 Aug 2018 | 40-4 v BarnsleyBarnsley 4-0 Oxford United | Sky Bet League One |
| 4 | Sat 11 Aug 2018 | 40-2 v Fleetwood TownOxford United 0-2 Fleetwood Town | Sky Bet League One |
| 5 | Tue 14 Aug 2018 | 42-0 v Coventry CityOxford United 2-0 Coventry City | Carabao Cup First Round |
| 6 | Sat 18 Aug 2018 | 41-4 v PortsmouthPortsmouth 4-1 Oxford United | Sky Bet League One |
| 7 | Tue 28 Aug 2018 | 4 3-0 v Newport CountyNewport County 0-3 Oxford United | Carabao Cup Second Round |
| 8 | Sat 22 Sep 2018 | 41-2 v WalsallOxford United 1-2 Walsall | Sky Bet League One |
| 9 | Tue 25 Sep 2018 | 4 0-3 v Manchester CityOxford United 0-3 Manchester City | Carabao Cup Third Round |
| 10 | Tue 2 Oct 2018 | 41-2 v Luton TownOxford United 1-2 Luton Town | Sky Bet League One |
| 11 | Sat 6 Oct 2018 | 40-0 v Southend UnitedSouthend United 0-0 Oxford United | Sky Bet League One |
| 12 | Tue 9 Oct 2018 | 41-2 v Northampton TownOxford United 1-2 Northampton Town | Checkatrade Trophy Southern Group F |
| 13 | Sat 13 Oct 2018 | 42-0 v Plymouth ArgyleOxford United 2-0 Plymouth Argyle | Sky Bet League One |
| 14 | Sat 20 Oct 2018 | 40-0 v Bristol RoversBristol Rovers 0-0 Oxford United | Sky Bet League One |
| 15 | Tue 23 Oct 2018 | 4 1-1 v Charlton AthleticCharlton Athletic 1-1 Oxford United | Sky Bet League One |
| 16 | Sat 27 Oct 2018 | 43-0 v Shrewsbury TownOxford United 3-0 Shrewsbury Town | Sky Bet League One |
| 17 | Sat 3 Nov 2018 | 4 3-3 v Scunthorpe UnitedScunthorpe United 3-3 Oxford United | Sky Bet League One |
| 18 | Tue 6 Nov 2018 | 43-0 v Wycombe WanderersWycombe Wanderers 0-3 Oxford United | Checkatrade Trophy Southern Group F |
| 19 | Sat 10 Nov 2018 | 40-0 v Forest Green RoversOxford United 0-0 Forest Green Rovers | Emirates FA Cup First Round |
| 20 | Sat 17 Nov 2018 | 41-0 v GillinghamOxford United 1-0 Gillingham | Sky Bet League One |
| 21 | Tue 20 Nov 2018 | 43-0 v Forest Green RoversForest Green Rovers 0-3 Oxford United | Emirates FA Cup First Round Replay |
| 22 | Tue 27 Nov 2018 | 44-2 v RochdaleOxford United 4-2 Rochdale | Sky Bet League One |
| 23 | Sat 1 Dec 2018 | 42-1 v Plymouth ArgylePlymouth Argyle 1-2 Oxford United | Emirates FA Cup Second Round |
| 24 | Sat 8 Dec 2018 | 42-2 v Peterborough UnitedPeterborough United 2-2 Oxford United | Sky Bet League One |
| 25 | Sat 15 Dec 2018 | 42-0 v BlackpoolOxford United 2-0 Blackpool | Sky Bet League One |
| 26 | Sat 22 Dec 2018 | 4 2-2 v Doncaster RoversDoncaster Rovers 2-2 Oxford United | Sky Bet League One |
| 27 | Wed 26 Dec 2018 | 4 0-1 v Southend UnitedOxford United 0-1 Southend United | Sky Bet League One |
| 28 | Sat 29 Dec 2018 | 40-2 v Bristol RoversOxford United 0-2 Bristol Rovers | Sky Bet League One |
| 29 | Tue 1 Jan 2019 | 4 0-3 v Plymouth ArgylePlymouth Argyle 3-0 Oxford United | Sky Bet League One |
| 30 | Tue 8 Jan 2019 | 41-1 v Cheltenham TownCheltenham Town 1-1 Oxford United | Checkatrade Trophy Second Round |
| 31 | Sat 12 Jan 2019 | 42-2 v Fleetwood TownFleetwood Town 2-2 Oxford United | Sky Bet League One |
| 32 | Sat 19 Jan 2019 | 42-1 v PortsmouthOxford United 2-1 Portsmouth | Sky Bet League One |
| 33 | Tue 22 Jan 2019 | 42-5 v BuryBury 5-2 Oxford United | Checkatrade Trophy Fourth Round |
| 34 | Tue 29 Jan 2019 | 42-2 v BarnsleyOxford United 2-2 Barnsley | Sky Bet League One |
| 35 | Sat 2 Feb 2019 | 40-0 v Burton AlbionBurton Albion 0-0 Oxford United | Sky Bet League One |
| 36 | Sat 9 Feb 2019 | 41-1 v SunderlandOxford United 1-1 Sunderland | Sky Bet League One |
| 37 | Sat 16 Feb 2019 | 4 0-1 v Peterborough UnitedOxford United 0-1 Peterborough United | Sky Bet League One |
| 38 | Sat 23 Feb 2019 | 41-0 v BlackpoolBlackpool 0-1 Oxford United | Sky Bet League One |
| 39 | Sat 2 Mar 2019 | 42-1 v Scunthorpe UnitedOxford United 2-1 Scunthorpe United | Sky Bet League One |
| 40 | Sat 9 Mar 2019 | 4 0-1 v GillinghamGillingham 1-0 Oxford United | Sky Bet League One |
| 41 | Tue 12 Mar 2019 | 4 0-0 v RochdaleRochdale 0-0 Oxford United | Sky Bet League One |
| 42 | Sat 16 Mar 2019 | 41-0 v Bradford CityOxford United 1-0 Bradford City | Sky Bet League One |
| 43 | Sat 23 Mar 2019 | 41-0 v Coventry CityCoventry City 0-1 Oxford United | Sky Bet League One |
| 44 | Sat 30 Mar 2019 | 42-1 v Wycombe WanderersOxford United 2-1 Wycombe Wanderers | Sky Bet League One |
| 45 | Sat 6 Apr 2019 | 43-1 v WalsallWalsall 1-3 Oxford United | Sky Bet League One |
| 46 | Sat 13 Apr 2019 | 40-0 v AFC WimbledonOxford United 0-0 AFC Wimbledon | Sky Bet League One |
| 47 | Fri 19 Apr 2019 | 42-1 v Charlton AthleticOxford United 2-1 Charlton Athletic | Sky Bet League One |
| 48 | Mon 22 Apr 2019 | 43-2 v Shrewsbury TownShrewsbury Town 2-3 Oxford United | Sky Bet League One |
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