| 1 | Sat 3 Aug 2019 | 1-1 v SunderlandSunderland 1-1 Oxford United | Sky Bet League One |
| 2 | Sat 10 Aug 2019 | 1-0 v Peterborough UnitedOxford United 1-0 Peterborough United | Sky Bet League One |
| 3 | Sat 17 Aug 2019 | 1-2 v BlackpoolBlackpool 2-1 Oxford United | Sky Bet League One |
| 4 | Tue 20 Aug 2019 | 2-4 v Burton AlbionOxford United 2-4 Burton Albion | Sky Bet League One |
| 5 | Sat 24 Aug 2019 | 1-3 v Bristol RoversBristol Rovers 3-1 Oxford United | Sky Bet League One |
| 6 | Sat 31 Aug 2019 | 3-3 v Coventry CityOxford United 3-3 Coventry City | Sky Bet League One |
| 7 | Sat 7 Sep 2019 | 1-2 v Fleetwood TownFleetwood Town 2-1 Oxford United | Sky Bet League One |
| 8 | Sat 14 Sep 2019 | 3-0 v Tranmere RoversOxford United 3-0 Tranmere Rovers | Sky Bet League One |
| 9 | Tue 17 Sep 2019 | 0-0 v Bolton WanderersBolton Wanderers 0-0 Oxford United | Sky Bet League One |
| 10 | Sat 21 Sep 2019 | 6-0 v Lincoln CityLincoln City 0-6 Oxford United | Sky Bet League One |
| 11 | Sat 28 Sep 2019 | 3-0 v GillinghamOxford United 3-0 Gillingham | Sky Bet League One |
| 12 | Sat 5 Oct 2019 | 2-2 v Accrington StanleyAccrington Stanley 2-2 Oxford United | Sky Bet League One |
| 13 | Sat 12 Oct 2019 | 3-0 v Doncaster RoversOxford United 3-0 Doncaster Rovers | Sky Bet League One |
| 14 | Sat 19 Oct 2019 | 2-1 v Rotherham UnitedRotherham United 1-2 Oxford United | Sky Bet League One |
| 15 | Sat 26 Oct 2019 | 3-0 v RochdaleOxford United 3-0 Rochdale | Sky Bet League One |
| 16 | Sun 10 Nov 2019 | 2-0 v Hayes & Yeading UnitedHayes & Yeading United 0-2 Oxford United | Emirates FA Cup First Round |
| 17 | Sat 23 Nov 2019 | 4-0 v Southend UnitedSouthend United 0-4 Oxford United | Sky Bet League One |
| 18 | Sat 30 Nov 2019 | 1-0 v WalsallWalsall 0-1 Oxford United | Emirates FA Cup Second Round |
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