| 1 | Sat 6 Feb 2021 | 302-3 v Doncaster RoversDoncaster Rovers 3-2 Oxford United | Sky Bet League One |
| 2 | Tue 9 Feb 2021 | 272-0 v Bristol RoversBristol Rovers 0-2 Oxford United | Sky Bet League One |
| 3 | Sun 14 Feb 2021 | 272-1 v Wigan AthleticOxford United 2-1 Wigan Athletic | Sky Bet League One |
| 4 | Sat 20 Feb 2021 | 270-0 v Ipswich TownIpswich Town 0-0 Oxford United | Sky Bet League One |
| 5 | Tue 23 Feb 2021 | 270-1 v PortsmouthOxford United 0-1 Portsmouth | Sky Bet League One |
| 6 | Sat 27 Feb 2021 | 271-1 v Milton Keynes DonsMilton Keynes Dons 1-1 Oxford United | Sky Bet League One |
| 7 | Tue 2 Mar 2021 | 270-0 v Peterborough UnitedOxford United 0-0 Peterborough United | Sky Bet League One |
| 8 | Sat 13 Mar 2021 | 270-2 v Hull CityHull City 2-0 Oxford United | Sky Bet League One |
| 9 | Tue 16 Mar 2021 | 273-0 v Doncaster RoversOxford United 3-0 Doncaster Rovers | Sky Bet League One |
| 10 | Fri 2 Apr 2021 | 271-3 v SunderlandSunderland 3-1 Oxford United | Sky Bet League One |
| 11 | Mon 5 Apr 2021 | 27 1-2 v Accrington StanleyOxford United 1-2 Accrington Stanley | Sky Bet League One |
| 12 | Sat 10 Apr 2021 | 276-0 v Crewe AlexandraCrewe Alexandra 0-6 Oxford United | Sky Bet League One |
| 13 | Tue 13 Apr 2021 | 274-1 v Shrewsbury TownOxford United 4-1 Shrewsbury Town | Sky Bet League One |
| 14 | Sat 17 Apr 2021 | 273-2 v GillinghamOxford United 3-2 Gillingham | Sky Bet League One |
| 15 | Tue 20 Apr 2021 | 271-2 v AFC WimbledonAFC Wimbledon 2-1 Oxford United | Sky Bet League One |
| 16 | Sat 24 Apr 2021 | 273-1 v Plymouth ArgyleOxford United 3-1 Plymouth Argyle | Sky Bet League One |
| 17 | Sat 1 May 2021 | 273-2 v Shrewsbury TownShrewsbury Town 2-3 Oxford United | Sky Bet League One |
| 18 | Sun 9 May 2021 | 274-0 v Burton AlbionOxford United 4-0 Burton Albion | Sky Bet League One |
| 19 | Tue 18 May 2021 | 270-3 v BlackpoolOxford United 0-3 Blackpool | Sky Bet League One Play-off |
| 20 | Fri 21 May 2021 | 273-3 v BlackpoolBlackpool 3-3 Oxford United | Sky Bet League One Play-off |
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