| 1 | Sat 10 Oct 2020 | 111-3 v GillinghamGillingham 3-1 Oxford United | Sky Bet League One |
| 2 | Sat 17 Oct 2020 | 110-2 v Peterborough UnitedPeterborough United 2-0 Oxford United | Sky Bet League One |
| 3 | Tue 10 Nov 2020 | 111-0 v WalsallWalsall 0-1 Oxford United | Papa John’s Trophy Group 10 |
| 4 | Tue 17 Nov 2020 | 110-2 v Crewe AlexandraOxford United 0-2 Crewe Alexandra | Sky Bet League One |
| 5 | Sat 2 Jan 2021 | 115-1 v Burton AlbionBurton Albion 1-5 Oxford United | Sky Bet League One |
| 6 | Tue 12 Jan 2021 | 111-0 v Cambridge UnitedOxford United 1-0 Cambridge United | Papa John’s Trophy Third Round |
| 7 | Sat 23 Jan 2021 | 11 2-0 v Bristol RoversOxford United 2-0 Bristol Rovers | Sky Bet League One |
| 8 | Tue 26 Jan 2021 | 114-3 v RochdaleRochdale 3-4 Oxford United | Sky Bet League One |
| 9 | Sat 30 Jan 2021 | 11 1-0 v Fleetwood TownOxford United 1-0 Fleetwood Town | Sky Bet League One |
| 10 | Tue 2 Feb 2021 | 113-1 v AFC WimbledonOxford United 3-1 AFC Wimbledon | Papa John’s Trophy Northern Group D |
| 11 | Sat 6 Feb 2021 | 112-3 v Doncaster RoversDoncaster Rovers 3-2 Oxford United | Sky Bet League One |
| 12 | Tue 9 Feb 2021 | 112-0 v Bristol RoversBristol Rovers 0-2 Oxford United | Sky Bet League One |
| 13 | Sun 14 Feb 2021 | 112-1 v Wigan AthleticOxford United 2-1 Wigan Athletic | Sky Bet League One |
| 14 | Tue 16 Feb 2021 | 110-2 v Tranmere RoversOxford United 0-2 Tranmere Rovers | Papa John’s Trophy Northern Group E |
| 15 | Sat 20 Feb 2021 | 11 0-0 v Ipswich TownIpswich Town 0-0 Oxford United | Sky Bet League One |
| 16 | Tue 23 Feb 2021 | 110-1 v PortsmouthOxford United 0-1 Portsmouth | Sky Bet League One |
| 17 | Sat 27 Feb 2021 | 111-1 v Milton Keynes DonsMilton Keynes Dons 1-1 Oxford United | Sky Bet League One |
| 18 | Sat 20 Mar 2021 | 110-2 v BlackpoolOxford United 0-2 Blackpool | Sky Bet League One |
| 19 | Tue 23 Mar 2021 | 110-1 v Northampton TownNorthampton Town 1-0 Oxford United | Sky Bet League One |
| 20 | Fri 26 Mar 2021 | 112-1 v Lincoln CityOxford United 2-1 Lincoln City | Sky Bet League One |
| 21 | Fri 2 Apr 2021 | 111-3 v SunderlandSunderland 3-1 Oxford United | Sky Bet League One |
| 22 | Mon 5 Apr 2021 | 111-2 v Accrington StanleyOxford United 1-2 Accrington Stanley | Sky Bet League One |
| 23 | Sat 10 Apr 2021 | 116-0 v Crewe AlexandraCrewe Alexandra 0-6 Oxford United | Sky Bet League One |
| 24 | Tue 13 Apr 2021 | 114-1 v Shrewsbury TownOxford United 4-1 Shrewsbury Town | Sky Bet League One |
| 25 | Sat 17 Apr 2021 | 113-2 v GillinghamOxford United 3-2 Gillingham | Sky Bet League One |
| 26 | Tue 20 Apr 2021 | 111-2 v AFC WimbledonAFC Wimbledon 2-1 Oxford United | Sky Bet League One |
| 27 | Sat 1 May 2021 | 113-2 v Shrewsbury TownShrewsbury Town 2-3 Oxford United | Sky Bet League One |
| 28 | Sun 9 May 2021 | 114-0 v Burton AlbionOxford United 4-0 Burton Albion | Sky Bet League One |
| 29 | Tue 18 May 2021 | 110-3 v BlackpoolOxford United 0-3 Blackpool | Sky Bet League One Play-off |
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