| 1 | Tue 15 Sep 2020 | 21-1 v WatfordOxford United 1-1 Watford | Carabao Cup Second Round |
| 2 | Sat 19 Sep 2020 | 20-2 v SunderlandOxford United 0-2 Sunderland | Sky Bet League One |
| 3 | Sat 26 Sep 2020 | 24-1 v Accrington StanleyAccrington Stanley 1-4 Oxford United | Sky Bet League One |
| 4 | Sat 10 Oct 2020 | 21-3 v GillinghamGillingham 3-1 Oxford United | Sky Bet League One |
| 5 | Sat 17 Oct 2020 | 2 0-2 v Peterborough UnitedPeterborough United 2-0 Oxford United | Sky Bet League One |
| 6 | Tue 20 Oct 2020 | 23-2 v Milton Keynes DonsOxford United 3-2 Milton Keynes Dons | Sky Bet League One |
| 7 | Tue 27 Oct 2020 | 20-2 v Charlton AthleticCharlton Athletic 2-0 Oxford United | Sky Bet League One |
| 8 | Sat 31 Oct 2020 | 20-2 v Fleetwood TownFleetwood Town 2-0 Oxford United | Sky Bet League One |
| 9 | Tue 3 Nov 2020 | 2 3-1 v RochdaleOxford United 3-1 Rochdale | Sky Bet League One |
| 10 | Tue 17 Nov 2020 | 2 0-2 v Crewe AlexandraOxford United 0-2 Crewe Alexandra | Sky Bet League One |
| 11 | Sat 21 Nov 2020 | 22-1 v Wigan AthleticWigan Athletic 1-2 Oxford United | Sky Bet League One |
| 12 | Tue 24 Nov 2020 | 2 1-1 v PortsmouthPortsmouth 1-1 Oxford United | Sky Bet League One |
| 13 | Tue 1 Dec 2020 | 20-0 v Ipswich TownOxford United 0-0 Ipswich Town | Sky Bet League One |
| 14 | Sat 5 Dec 2020 | 21-1 v Hull CityOxford United 1-1 Hull City | Sky Bet League One |
| 15 | Tue 8 Dec 2020 | 21-1 v Forest Green RoversOxford United 1-1 Forest Green Rovers | Papa John’s Trophy Second Round |
| 16 | Tue 15 Dec 2020 | 24-0 v Northampton TownOxford United 4-0 Northampton Town | Sky Bet League One |
| 17 | Sat 26 Dec 2020 | 22-0 v AFC WimbledonOxford United 2-0 AFC Wimbledon | Sky Bet League One |
| 18 | Tue 29 Dec 2020 | 2 3-2 v Plymouth ArgylePlymouth Argyle 2-3 Oxford United | Sky Bet League One |
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