| 1 | Sat 14 Aug 2021 | 74-2 v StrasbourgParis St Germain 4-2 Strasbourg | French Ligue 1 |
| 2 | Fri 20 Aug 2021 | 7 4-2 v BrestBrest 2-4 Paris St Germain | French Ligue 1 |
| 3 | Sun 29 Aug 2021 | 72-0 v ReimsReims 0-2 Paris St Germain | French Ligue 1 |
| 4 | Wed 15 Sep 2021 | 71-1 v Club BruggeClub Brugge 1-1 Paris St Germain | UEFA Champions League Group A |
| 5 | Sun 19 Sep 2021 | 72-1 v LyonParis St Germain 2-1 Lyon | French Ligue 1 |
| 6 | Wed 22 Sep 2021 | 72-1 v MetzMetz 1-2 Paris St Germain | French Ligue 1 |
| 7 | Sat 25 Sep 2021 | 72-0 v MontpellierParis St Germain 2-0 Montpellier | French Ligue 1 |
| 8 | Tue 28 Sep 2021 | 72-0 v Manchester CityParis St Germain 2-0 Manchester City | UEFA Champions League Group A |
| 9 | Sun 3 Oct 2021 | 7 0-2 v RennesRennes 2-0 Paris St Germain | French Ligue 1 |
| 10 | Fri 15 Oct 2021 | 72-1 v AngersParis St Germain 2-1 Angers | French Ligue 1 |
| 11 | Tue 19 Oct 2021 | 73-2 v RB LeipzigParis St Germain 3-2 RB Leipzig | UEFA Champions League Group A |
| 12 | Sun 24 Oct 2021 | 70-0 v MarseilleMarseille 0-0 Paris St Germain | French Ligue 1 |
| 13 | Wed 3 Nov 2021 | 72-2 v RB LeipzigRB Leipzig 2-2 Paris St Germain | UEFA Champions League Group A |
| 14 | Sat 6 Nov 2021 | 7 3-2 v BordeauxBordeaux 2-3 Paris St Germain | French Ligue 1 |
| 15 | Sat 20 Nov 2021 | 73-1 v NantesParis St Germain 3-1 Nantes | French Ligue 1 |
| 16 | Wed 24 Nov 2021 | 71-2 v Manchester CityManchester City 2-1 Paris St Germain | UEFA Champions League Group A |
| 17 | Sun 28 Nov 2021 | 73-1 v Saint ÉtienneSaint Étienne 1-3 Paris St Germain | French Ligue 1 |
| 18 | Wed 1 Dec 2021 | 70-0 v NiceParis St Germain 0-0 Nice | French Ligue 1 |
| 19 | Sat 4 Dec 2021 | 71-1 v LensLens 1-1 Paris St Germain | French Ligue 1 |
| 20 | Tue 7 Dec 2021 | 7 4-1 v Club BruggeParis St Germain 4-1 Club Brugge | UEFA Champions League Group A |
| 21 | Sun 12 Dec 2021 | 7 2-0 v MonacoParis St Germain 2-0 Monaco | French Ligue 1 |
| 22 | Sun 9 Jan 2022 | 71-1 v LyonLyon 1-1 Paris St Germain | French Ligue 1 |
| 23 | Sat 15 Jan 2022 | 7 2-0 v BrestParis St Germain 2-0 Brest | French Ligue 1 |
| 24 | Sun 23 Jan 2022 | 74-0 v ReimsParis St Germain 4-0 Reims | French Ligue 1 |
| 25 | Sun 6 Feb 2022 | 75-1 v LilleLille 1-5 Paris St Germain | French Ligue 1 |
| 26 | Fri 11 Feb 2022 | 7 1-0 v RennesParis St Germain 1-0 Rennes | French Ligue 1 |
| 27 | Tue 15 Feb 2022 | 71-0 v Real MadridParis St Germain 1-0 Real Madrid | UEFA Champions League Round of 16 |
| 28 | Sat 19 Feb 2022 | 7 1-3 v NantesNantes 3-1 Paris St Germain | French Ligue 1 |
| 29 | Sat 26 Feb 2022 | 73-1 v Saint ÉtienneParis St Germain 3-1 Saint Étienne | French Ligue 1 |
| 30 | Wed 9 Mar 2022 | 71-3 v Real MadridReal Madrid 3-1 Paris St Germain | UEFA Champions League Round of 16 |
| 31 | Sun 13 Mar 2022 | 73-0 v BordeauxParis St Germain 3-0 Bordeaux | French Ligue 1 |
| 32 | Sun 20 Mar 2022 | 7 0-3 v MonacoMonaco 3-0 Paris St Germain | French Ligue 1 |
| 33 | Sun 3 Apr 2022 | 75-1 v LorientParis St Germain 5-1 Lorient | French Ligue 1 |
| 34 | Sat 9 Apr 2022 | 76-1 v ClermontClermont 1-6 Paris St Germain | French Ligue 1 |
| 35 | Sun 17 Apr 2022 | 7 2-1 v MarseilleParis St Germain 2-1 Marseille | French Ligue 1 |
| 36 | Wed 20 Apr 2022 | 73-0 v AngersAngers 0-3 Paris St Germain | French Ligue 1 |
| 37 | Sat 23 Apr 2022 | 71-1 v LensParis St Germain 1-1 Lens | French Ligue 1 |
| 38 | Fri 29 Apr 2022 | 73-3 v StrasbourgStrasbourg 3-3 Paris St Germain | French Ligue 1 |
| 39 | Sun 8 May 2022 | 72-2 v TroyesParis St Germain 2-2 Troyes | French Ligue 1 |
| 40 | Sat 14 May 2022 | 7 4-0 v MontpellierMontpellier 0-4 Paris St Germain | French Ligue 1 |
| 41 | Sat 21 May 2022 | 75-0 v MetzParis St Germain 5-0 Metz | French Ligue 1 |
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