| 1 | Sat 30 Jul 2022 | 11-0 v BarnsleyPlymouth Argyle 1-0 Barnsley | Sky Bet League One |
| 2 | Sat 6 Aug 2022 | 11-2 v Fleetwood TownFleetwood Town 2-1 Plymouth Argyle | Sky Bet League One |
| 3 | Wed 10 Aug 2022 | 10-2 v Peterborough UnitedPlymouth Argyle 0-2 Peterborough United | Carabao Cup First Round |
| 4 | Sat 13 Aug 2022 | 12-0 v Peterborough UnitedPlymouth Argyle 2-0 Peterborough United | Sky Bet League One |
| 5 | Tue 16 Aug 2022 | 11-5 v Charlton AthleticCharlton Athletic 5-1 Plymouth Argyle | Sky Bet League One |
| 6 | Sat 20 Aug 2022 | 13-0 v Forest Green RoversForest Green Rovers 0-3 Plymouth Argyle | Sky Bet League One |
| 7 | Sat 27 Aug 2022 | 12-0 v Bolton WanderersPlymouth Argyle 2-0 Bolton Wanderers | Sky Bet League One |
| 8 | Sat 3 Sep 2022 | 13-2 v Derby CountyDerby County 2-3 Plymouth Argyle | Sky Bet League One |
| 9 | Tue 13 Sep 2022 | 11-0 v Oxford UnitedPlymouth Argyle 1-0 Oxford United | Sky Bet League One |
| 10 | Sat 17 Sep 2022 | 12-2 v PortsmouthPortsmouth 2-2 Plymouth Argyle | Sky Bet League One |
| 11 | Sun 25 Sep 2022 | 12-1 v Ipswich TownPlymouth Argyle 2-1 Ipswich Town | Sky Bet League One |
| 12 | Sat 1 Oct 2022 | 11-0 v Wycombe WanderersWycombe Wanderers 0-1 Plymouth Argyle | Sky Bet League One |
| 13 | Tue 4 Oct 2022 | 12-1 v Sheffield WednesdayPlymouth Argyle 2-1 Sheffield Wednesday | Sky Bet League One |
| 14 | Sat 8 Oct 2022 | 13-0 v Accrington StanleyPlymouth Argyle 3-0 Accrington Stanley | Sky Bet League One |
| 15 | Sat 15 Oct 2022 | 14-1 v Milton Keynes DonsMilton Keynes Dons 1-4 Plymouth Argyle | Sky Bet League One |
| 16 | Sat 22 Oct 2022 | 12-2 v Bristol RoversBristol Rovers 2-2 Plymouth Argyle | Sky Bet League One |
| 17 | Tue 25 Oct 2022 | 12-1 v Shrewsbury TownPlymouth Argyle 2-1 Shrewsbury Town | Sky Bet League One |
| 18 | Mon 31 Oct 2022 | 14-2 v Exeter CityPlymouth Argyle 4-2 Exeter City | Sky Bet League One |
| 19 | Sat 5 Nov 2022 | 11-5 v Grimsby TownGrimsby Town 5-1 Plymouth Argyle | Emirates FA Cup First Round |
| 20 | Sat 12 Nov 2022 | 11-1 v Lincoln CityLincoln City 1-1 Plymouth Argyle | Sky Bet League One |
| 21 | Sat 19 Nov 2022 | 12-2 v Burton AlbionBurton Albion 2-2 Plymouth Argyle | Sky Bet League One |
| 22 | Fri 2 Dec 2022 | 10-2 v Port ValePlymouth Argyle 0-2 Port Vale | Sky Bet League One |
| 23 | Sat 10 Dec 2022 | 10-0 v Cambridge UnitedCambridge United 0-0 Plymouth Argyle | Sky Bet League One |
| 24 | Sat 17 Dec 2022 | 12-1 v MorecambePlymouth Argyle 2-1 Morecambe | Sky Bet League One |
| 25 | Mon 26 Dec 2022 | 11-0 v Cheltenham TownCheltenham Town 0-1 Plymouth Argyle | Sky Bet League One |
| 26 | Thu 29 Dec 2022 | 11-0 v Wycombe WanderersPlymouth Argyle 1-0 Wycombe Wanderers | Sky Bet League One |
| 27 | Sun 1 Jan 2023 | 13-1 v Milton Keynes DonsPlymouth Argyle 3-1 Milton Keynes Dons | Sky Bet League One |
| 28 | Sat 7 Jan 2023 | 1 0-0 v Bolton WanderersBolton Wanderers 0-0 Plymouth Argyle | Sky Bet League One |
| 29 | Sat 14 Jan 2023 | 11-1 v Ipswich TownIpswich Town 1-1 Plymouth Argyle | Sky Bet League One |
| 30 | Sat 21 Jan 2023 | 14-2 v Cheltenham TownPlymouth Argyle 4-2 Cheltenham Town | Sky Bet League One |
| 31 | Sat 4 Feb 2023 | 10-1 v Sheffield WednesdaySheffield Wednesday 1-0 Plymouth Argyle | Sky Bet League One |
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