| 1 | Tue 17 Jul 2018 | 33-0 v ClydeQueen of the South 3-0 Clyde | Betfred Cup Group G |
| 2 | Sat 21 Jul 2018 | 34-0 v Edinburgh CityEdinburgh City 0-4 Queen of the South | Betfred Cup Group G |
| 3 | Tue 24 Jul 2018 | 30-2 v MotherwellMotherwell 2-0 Queen of the South | Betfred Cup Group G |
| 4 | Sat 4 Aug 2018 | 32-2 v Greenock MortonGreenock Morton 2-2 Queen of the South | Ladbrokes Championship |
| 5 | Sat 11 Aug 2018 | 31-2 v Dundee UnitedQueen of the South 1-2 Dundee United | Ladbrokes Championship |
| 6 | Tue 14 Aug 2018 | 33-0 v StenhousemuirStenhousemuir 0-3 Queen of the South | IRN-BRU Cup First Round |
| 7 | Sat 18 Aug 2018 | 32-4 v St JohnstoneQueen of the South 2-4 St Johnstone | Betfred Cup Second Round |
| 8 | Sat 25 Aug 2018 | 33-0 v FalkirkFalkirk 0-3 Queen of the South | Ladbrokes Championship |
| 9 | Sat 1 Sep 2018 | 35-0 v Ayr UnitedQueen of the South 5-0 Ayr United | Ladbrokes Championship |
| 10 | Sat 8 Sep 2018 | 34-3 v CrusadersQueen of the South 4-3 Crusaders | IRN-BRU Cup Second Round |
| 11 | Sat 15 Sep 2018 | 30-0 v Ross CountyQueen of the South 0-0 Ross County | Ladbrokes Championship |
| 12 | Sat 22 Sep 2018 | 32-3 v Partick ThistlePartick Thistle 3-2 Queen of the South | Ladbrokes Championship |
| 13 | Sat 29 Sep 2018 | 30-0 v Inverness Caledonian ThistleInverness Caledonian Thistle 0-0 Queen of the South | Ladbrokes Championship |
| 14 | Sat 6 Oct 2018 | 33-3 v Alloa AthleticQueen of the South 3-3 Alloa Athletic | Ladbrokes Championship |
| 15 | Sat 13 Oct 2018 | 30-2 v East FifeEast Fife 2-0 Queen of the South | IRN-BRU Cup Third Round |
| 16 | Sat 20 Oct 2018 | 31-0 v Dunfermline AthleticDunfermline Athletic 0-1 Queen of the South | Ladbrokes Championship |
| 17 | Sat 27 Oct 2018 | 32-0 v FalkirkQueen of the South 2-0 Falkirk | Ladbrokes Championship |
| 18 | Tue 30 Oct 2018 | 31-2 v Greenock MortonQueen of the South 1-2 Greenock Morton | Ladbrokes Championship |
| 19 | Sat 3 Nov 2018 | 30-2 v Dundee UnitedDundee United 2-0 Queen of the South | Ladbrokes Championship |
| 20 | Sat 10 Nov 2018 | 31-1 v Ayr UnitedAyr United 1-1 Queen of the South | Ladbrokes Championship |
| 21 | Sat 17 Nov 2018 | 33-3 v Inverness Caledonian ThistleQueen of the South 3-3 Inverness Caledonian Thistle | Ladbrokes Championship |
| 22 | Sat 24 Nov 2018 | 34-1 v Formartine UnitedQueen of the South 4-1 Formartine United | William Hill Scottish Cup Third Round |
| 23 | Sat 1 Dec 2018 | 31-0 v Partick ThistleQueen of the South 1-0 Partick Thistle | Ladbrokes Championship |
| 24 | Sat 8 Dec 2018 | 31-1 v Ross CountyRoss County 1-1 Queen of the South | Ladbrokes Championship |
| 25 | Sat 15 Dec 2018 | 30-0 v Dunfermline AthleticQueen of the South 0-0 Dunfermline Athletic | Ladbrokes Championship |
| 26 | Sat 22 Dec 2018 | 30-2 v Alloa AthleticAlloa Athletic 2-0 Queen of the South | Ladbrokes Championship |
| 27 | Sat 29 Dec 2018 | 31-1 v Ayr UnitedQueen of the South 1-1 Ayr United | Ladbrokes Championship |
| 28 | Sat 5 Jan 2019 | 3 2-1 v Inverness Caledonian ThistleInverness Caledonian Thistle 1-2 Queen of the South | Ladbrokes Championship |
| 29 | Sat 12 Jan 2019 | 34-0 v Ross CountyQueen of the South 4-0 Ross County | Ladbrokes Championship |
| 30 | Sat 19 Jan 2019 | 31-1 v DundeeDundee 1-1 Queen of the South | William Hill Scottish Cup Fourth Round |
| 31 | Sat 26 Jan 2019 | 3 1-2 v Partick ThistlePartick Thistle 2-1 Queen of the South | Ladbrokes Championship |
| 32 | Tue 29 Jan 2019 | 33-0 v DundeeQueen of the South 3-0 Dundee | William Hill Scottish Cup Fourth Round Replay |
| 33 | Sat 2 Feb 2019 | 30-3 v FalkirkFalkirk 3-0 Queen of the South | Ladbrokes Championship |
| 34 | Sun 10 Feb 2019 | 31-4 v AberdeenAberdeen 4-1 Queen of the South | William Hill Scottish Cup Fifth Round |
| 35 | Sat 16 Feb 2019 | 30-1 v Dundee UnitedQueen of the South 0-1 Dundee United | Ladbrokes Championship |
| 36 | Sat 23 Feb 2019 | 31-2 v Alloa AthleticQueen of the South 1-2 Alloa Athletic | Ladbrokes Championship |
| 37 | Tue 26 Feb 2019 | 30-1 v Greenock MortonGreenock Morton 1-0 Queen of the South | Ladbrokes Championship |
| 38 | Sat 2 Mar 2019 | 30-1 v Dunfermline AthleticDunfermline Athletic 1-0 Queen of the South | Ladbrokes Championship |
| 39 | Sat 30 Mar 2019 | 32-1 v Dundee UnitedDundee United 1-2 Queen of the South | Ladbrokes Championship |
| 40 | Tue 2 Apr 2019 | 31-1 v FalkirkQueen of the South 1-1 Falkirk | Ladbrokes Championship |
| 41 | Sat 6 Apr 2019 | 3 1-1 v Greenock MortonQueen of the South 1-1 Greenock Morton | Ladbrokes Championship |
| 42 | Tue 9 Apr 2019 | 30-1 v Ayr UnitedAyr United 1-0 Queen of the South | Ladbrokes Championship |
| 43 | Sat 13 Apr 2019 | 30-1 v Alloa AthleticAlloa Athletic 1-0 Queen of the South | Ladbrokes Championship |
| 44 | Sat 20 Apr 2019 | 32-1 v Dunfermline AthleticQueen of the South 2-1 Dunfermline Athletic | Ladbrokes Championship |
| 45 | Fri 26 Apr 2019 | 30-4 v Ross CountyRoss County 4-0 Queen of the South | Ladbrokes Championship |
| 46 | Sat 4 May 2019 | 30-3 v Partick ThistleQueen of the South 0-3 Partick Thistle | Ladbrokes Championship |
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