| 1 | Sun 15 Aug 2021 | 70-3 v SevillaSevilla 3-0 Rayo Vallecano | Spanish La Liga |
| 2 | Sun 22 Aug 2021 | 70-1 v Real SociedadReal Sociedad 1-0 Rayo Vallecano | Spanish La Liga |
| 3 | Sun 29 Aug 2021 | 74-0 v GranadaRayo Vallecano 4-0 Granada | Spanish La Liga |
| 4 | Sat 11 Sep 2021 | 71-1 v LevanteLevante 1-1 Rayo Vallecano | Spanish La Liga |
| 5 | Sat 18 Sep 2021 | 73-0 v GetafeRayo Vallecano 3-0 Getafe | Spanish La Liga |
| 6 | Tue 21 Sep 2021 | 72-1 v Athletic BilbaoAthletic Bilbao 1-2 Rayo Vallecano | Spanish La Liga |
| 7 | Sun 26 Sep 2021 | 7 3-1 v CádizRayo Vallecano 3-1 Cádiz | Spanish La Liga |
| 8 | Sat 2 Oct 2021 | 70-1 v OsasunaOsasuna 1-0 Rayo Vallecano | Spanish La Liga |
| 9 | Sun 17 Oct 2021 | 72-1 v ElcheRayo Vallecano 2-1 Elche | Spanish La Liga |
| 10 | Sun 24 Oct 2021 | 72-3 v Real BetisReal Betis 3-2 Rayo Vallecano | Spanish La Liga |
| 11 | Wed 27 Oct 2021 | 71-0 v BarcelonaRayo Vallecano 1-0 Barcelona | Spanish La Liga |
| 12 | Mon 1 Nov 2021 | 7 0-0 v Celta VigoRayo Vallecano 0-0 Celta Vigo | Spanish La Liga |
| 13 | Sat 6 Nov 2021 | 71-2 v Real MadridReal Madrid 2-1 Rayo Vallecano | Spanish La Liga |
| 14 | Mon 22 Nov 2021 | 73-1 v MallorcaRayo Vallecano 3-1 Mallorca | Spanish La Liga |
| 15 | Sat 27 Nov 2021 | 7 1-1 v ValenciaValencia 1-1 Rayo Vallecano | Spanish La Liga |
| 16 | Sun 5 Dec 2021 | 71-0 v EspanyolRayo Vallecano 1-0 Espanyol | Spanish La Liga |
| 17 | Sun 12 Dec 2021 | 7 0-2 v VillarrealVillarreal 2-0 Rayo Vallecano | Spanish La Liga |
| 18 | Sat 18 Dec 2021 | 72-0 v AlavésRayo Vallecano 2-0 Alavés | Spanish La Liga |
| 19 | Sun 2 Jan 2022 | 70-2 v Atlético MadridAtlético Madrid 2-0 Rayo Vallecano | Spanish La Liga |
| 20 | Sun 9 Jan 2022 | 71-1 v Real BetisRayo Vallecano 1-1 Real Betis | Spanish La Liga |
| 21 | Sun 23 Jan 2022 | 70-1 v Athletic BilbaoRayo Vallecano 0-1 Athletic Bilbao | Spanish La Liga |
| 22 | Sat 5 Feb 2022 | 70-2 v Celta VigoCelta Vigo 2-0 Rayo Vallecano | Spanish La Liga |
| 23 | Sat 12 Feb 2022 | 70-3 v OsasunaRayo Vallecano 0-3 Osasuna | Spanish La Liga |
| 24 | Fri 18 Feb 2022 | 71-2 v ElcheElche 2-1 Rayo Vallecano | Spanish La Liga |
| 25 | Sat 26 Feb 2022 | 70-1 v Real MadridRayo Vallecano 0-1 Real Madrid | Spanish La Liga |
| 26 | Sun 6 Mar 2022 | 7 0-2 v CádizCádiz 2-0 Rayo Vallecano | Spanish La Liga |
| 27 | Sat 19 Mar 2022 | 70-1 v Atlético MadridRayo Vallecano 0-1 Atlético Madrid | Spanish La Liga |
| 28 | Sun 3 Apr 2022 | 72-2 v GranadaGranada 2-2 Rayo Vallecano | Spanish La Liga |
| 29 | Mon 11 Apr 2022 | 71-1 v ValenciaRayo Vallecano 1-1 Valencia | Spanish La Liga |
| 30 | Sat 16 Apr 2022 | 7 0-1 v AlavésAlavés 1-0 Rayo Vallecano | Spanish La Liga |
| 31 | Thu 21 Apr 2022 | 71-0 v EspanyolEspanyol 0-1 Rayo Vallecano | Spanish La Liga |
| 32 | Sun 24 Apr 2022 | 7 1-0 v BarcelonaBarcelona 0-1 Rayo Vallecano | Spanish La Liga |
| 33 | Sun 1 May 2022 | 71-1 v Real SociedadRayo Vallecano 1-1 Real Sociedad | Spanish La Liga |
| 34 | Sun 8 May 2022 | 70-0 v GetafeGetafe 0-0 Rayo Vallecano | Spanish La Liga |
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