| 1 | Sat 11 Sep 2021 | 213-3 v Queens Park RangersReading 3-3 Queens Park Rangers | Sky Bet Championship |
| 2 | Tue 14 Sep 2021 | 213-1 v Peterborough UnitedReading 3-1 Peterborough United | Sky Bet Championship |
| 3 | Sat 18 Sep 2021 | 21 2-1 v FulhamFulham 1-2 Reading | Sky Bet Championship |
| 4 | Sat 25 Sep 2021 | 21 1-0 v MiddlesbroughReading 1-0 Middlesbrough | Sky Bet Championship |
| 5 | Wed 29 Sep 2021 | 210-1 v Derby CountyDerby County 1-0 Reading | Sky Bet Championship |
| 6 | Sat 2 Oct 2021 | 211-0 v Cardiff CityCardiff City 0-1 Reading | Sky Bet Championship |
| 7 | Sat 16 Oct 2021 | 211-0 v BarnsleyReading 1-0 Barnsley | Sky Bet Championship |
| 8 | Wed 20 Oct 2021 | 212-3 v BlackpoolReading 2-3 Blackpool | Sky Bet Championship |
| 9 | Sat 23 Oct 2021 | 210-2 v Blackburn RoversBlackburn Rovers 2-0 Reading | Sky Bet Championship |
| 10 | Sat 30 Oct 2021 | 210-2 v AFC BournemouthReading 0-2 AFC Bournemouth | Sky Bet Championship |
| 11 | Tue 2 Nov 2021 | 210-1 v MillwallMillwall 1-0 Reading | Sky Bet Championship |
| 12 | Sat 6 Nov 2021 | 212-1 v Birmingham CityBirmingham City 1-2 Reading | Sky Bet Championship |
| 13 | Sat 20 Nov 2021 | 21 1-1 v Nottingham ForestReading 1-1 Nottingham Forest | Sky Bet Championship |
| 14 | Tue 23 Nov 2021 | 210-1 v Sheffield UnitedReading 0-1 Sheffield United | Sky Bet Championship |
| 15 | Sat 27 Nov 2021 | 213-2 v Swansea CitySwansea City 2-3 Reading | Sky Bet Championship |
| 16 | Sat 4 Dec 2021 | 21 1-1 v Hull CityReading 1-1 Hull City | Sky Bet Championship |
| 17 | Sat 11 Dec 2021 | 210-1 v West Bromwich AlbionWest Bromwich Albion 1-0 Reading | Sky Bet Championship |
| 18 | Mon 3 Jan 2022 | 212-2 v Derby CountyReading 2-2 Derby County | Sky Bet Championship |
| 19 | Sat 22 Jan 2022 | 213-4 v Huddersfield TownReading 3-4 Huddersfield Town | Sky Bet Championship |
| 20 | Sat 29 Jan 2022 | 210-4 v Queens Park RangersQueens Park Rangers 4-0 Reading | Sky Bet Championship |
| 21 | Wed 9 Feb 2022 | 211-2 v Bristol CityBristol City 2-1 Reading | Sky Bet Championship |
| 22 | Sat 12 Feb 2022 | 212-3 v Coventry CityReading 2-3 Coventry City | Sky Bet Championship |
| 23 | Wed 16 Feb 2022 | 210-0 v Peterborough UnitedPeterborough United 0-0 Reading | Sky Bet Championship |
| 24 | Sat 19 Feb 2022 | 213-2 v Preston North EndPreston North End 2-3 Reading | Sky Bet Championship |
| 25 | Fri 15 Apr 2022 | 212-1 v Sheffield UnitedSheffield United 1-2 Reading | Sky Bet Championship |
| 26 | Mon 18 Apr 2022 | 214-4 v Swansea CityReading 4-4 Swansea City | Sky Bet Championship |
| 27 | Sat 23 Apr 2022 | 210-3 v Hull CityHull City 3-0 Reading | Sky Bet Championship |
| 28 | Sat 30 Apr 2022 | 210-1 v West Bromwich AlbionReading 0-1 West Bromwich Albion | Sky Bet Championship |
| 29 | Sat 7 May 2022 | 21 0-1 v Luton TownLuton Town 1-0 Reading | Sky Bet Championship |
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