| 1 | Sat 7 Aug 2021 | 42-3 v Stoke CityStoke City 3-2 Reading | Sky Bet Championship |
| 2 | Sat 14 Aug 2021 | 4 2-1 v Preston North EndReading 2-1 Preston North End | Sky Bet Championship |
| 3 | Tue 17 Aug 2021 | 42-3 v Bristol CityReading 2-3 Bristol City | Sky Bet Championship |
| 4 | Sat 21 Aug 2021 | 41-2 v Coventry CityCoventry City 2-1 Reading | Sky Bet Championship |
| 5 | Sat 28 Aug 2021 | 40-4 v Huddersfield TownHuddersfield Town 4-0 Reading | Sky Bet Championship |
| 6 | Sat 11 Sep 2021 | 4 3-3 v Queens Park RangersReading 3-3 Queens Park Rangers | Sky Bet Championship |
| 7 | Tue 14 Sep 2021 | 43-1 v Peterborough UnitedReading 3-1 Peterborough United | Sky Bet Championship |
| 8 | Sat 18 Sep 2021 | 42-1 v FulhamFulham 1-2 Reading | Sky Bet Championship |
| 9 | Wed 19 Jan 2022 | 40-2 v Luton TownReading 0-2 Luton Town | Sky Bet Championship |
| 10 | Sat 22 Jan 2022 | 4 3-4 v Huddersfield TownReading 3-4 Huddersfield Town | Sky Bet Championship |
| 11 | Sat 29 Jan 2022 | 40-4 v Queens Park RangersQueens Park Rangers 4-0 Reading | Sky Bet Championship |
| 12 | Wed 9 Feb 2022 | 41-2 v Bristol CityBristol City 2-1 Reading | Sky Bet Championship |
| 13 | Sat 12 Feb 2022 | 42-3 v Coventry CityReading 2-3 Coventry City | Sky Bet Championship |
| 14 | Wed 16 Feb 2022 | 40-0 v Peterborough UnitedPeterborough United 0-0 Reading | Sky Bet Championship |
| 15 | Sat 19 Feb 2022 | 43-2 v Preston North EndPreston North End 2-3 Reading | Sky Bet Championship |
| 16 | Tue 22 Feb 2022 | 42-1 v Birmingham CityReading 2-1 Birmingham City | Sky Bet Championship |
| 17 | Sat 26 Feb 2022 | 41-4 v BlackpoolBlackpool 4-1 Reading | Sky Bet Championship |
| 18 | Sat 5 Mar 2022 | 40-1 v MillwallReading 0-1 Millwall | Sky Bet Championship |
| 19 | Sat 12 Mar 2022 | 4 0-4 v Nottingham ForestNottingham Forest 4-0 Reading | Sky Bet Championship |
| 20 | Tue 15 Mar 2022 | 41-1 v AFC BournemouthAFC Bournemouth 1-1 Reading | Sky Bet Championship |
| 21 | Sat 19 Mar 2022 | 41-0 v Blackburn RoversReading 1-0 Blackburn Rovers | Sky Bet Championship |
| 22 | Sat 2 Apr 2022 | 41-1 v BarnsleyBarnsley 1-1 Reading | Sky Bet Championship |
| 23 | Tue 5 Apr 2022 | 42-1 v Stoke CityReading 2-1 Stoke City | Sky Bet Championship |
| 24 | Sat 9 Apr 2022 | 41-2 v Cardiff CityReading 1-2 Cardiff City | Sky Bet Championship |
| 25 | Fri 15 Apr 2022 | 4 2-1 v Sheffield UnitedSheffield United 1-2 Reading | Sky Bet Championship |
| 26 | Mon 18 Apr 2022 | 4 4-4 v Swansea CityReading 4-4 Swansea City | Sky Bet Championship |
| 27 | Sat 23 Apr 2022 | 4 0-3 v Hull CityHull City 3-0 Reading | Sky Bet Championship |
| 28 | Sat 30 Apr 2022 | 40-1 v West Bromwich AlbionReading 0-1 West Bromwich Albion | Sky Bet Championship |
| 29 | Sat 7 May 2022 | 40-1 v Luton TownLuton Town 1-0 Reading | Sky Bet Championship |
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