| 1 | Thu 16 Sep 2021 | 254-3 v CelticReal Betis 4-3 Celtic | UEFA Europa League Group G |
| 2 | Sun 19 Sep 2021 | 25 2-2 v EspanyolReal Betis 2-2 Espanyol | Spanish La Liga |
| 3 | Thu 23 Sep 2021 | 253-1 v OsasunaOsasuna 1-3 Real Betis | Spanish La Liga |
| 4 | Sun 26 Sep 2021 | 252-0 v GetafeReal Betis 2-0 Getafe | Spanish La Liga |
| 5 | Thu 21 Oct 2021 | 251-1 v Bayer 04 LeverkusenReal Betis 1-1 Bayer 04 Leverkusen | UEFA Europa League Group G |
| 6 | Sun 24 Oct 2021 | 253-2 v Rayo VallecanoReal Betis 3-2 Rayo Vallecano | Spanish La Liga |
| 7 | Wed 27 Oct 2021 | 254-1 v ValenciaReal Betis 4-1 Valencia | Spanish La Liga |
| 8 | Sun 31 Oct 2021 | 250-3 v Atlético MadridAtlético Madrid 3-0 Real Betis | Spanish La Liga |
| 9 | Sun 7 Nov 2021 | 250-2 v SevillaReal Betis 0-2 Sevilla | Spanish La Liga |
| 10 | Thu 25 Nov 2021 | 252-0 v Ferencvárosi TCReal Betis 2-0 Ferencvárosi TC | UEFA Europa League Group G |
| 11 | Tue 18 Jan 2022 | 254-0 v AlavésReal Betis 4-0 Alavés | Spanish La Liga |
| 12 | Fri 21 Jan 2022 | 254-1 v EspanyolEspanyol 1-4 Real Betis | Spanish La Liga |
| 13 | Sun 27 Feb 2022 | 251-2 v SevillaSevilla 2-1 Real Betis | Spanish La Liga |
| 14 | Sun 6 Mar 2022 | 251-3 v Atlético MadridReal Betis 1-3 Atlético Madrid | Spanish La Liga |
| 15 | Wed 9 Mar 2022 | 251-2 v Eintracht FrankfurtReal Betis 1-2 Eintracht Frankfurt | UEFA Europa League Round of 16 |
| 16 | Sun 20 Mar 2022 | 250-0 v Celta VigoCelta Vigo 0-0 Real Betis | Spanish La Liga |
| 17 | Sun 3 Apr 2022 | 254-1 v OsasunaReal Betis 4-1 Osasuna | Spanish La Liga |
| 18 | Sat 9 Apr 2022 | 252-1 v CádizCádiz 1-2 Real Betis | Spanish La Liga |
| 19 | Fri 15 Apr 2022 | 25 0-0 v Real SociedadReal Sociedad 0-0 Real Betis | Spanish La Liga |
| 20 | Mon 2 May 2022 | 250-0 v GetafeGetafe 0-0 Real Betis | Spanish La Liga |
| 21 | Sat 7 May 2022 | 251-2 v BarcelonaReal Betis 1-2 Barcelona | Spanish La Liga |
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