| 1 | Sat 28 Aug 2021 | 16 0-1 v Real MadridReal Betis 0-1 Real Madrid | Spanish La Liga |
| 2 | Mon 13 Sep 2021 | 162-1 v GranadaGranada 1-2 Real Betis | Spanish La Liga |
| 3 | Sun 19 Sep 2021 | 16 2-2 v EspanyolReal Betis 2-2 Espanyol | Spanish La Liga |
| 4 | Sun 26 Sep 2021 | 162-0 v GetafeReal Betis 2-0 Getafe | Spanish La Liga |
| 5 | Thu 30 Sep 2021 | 163-1 v Ferencvárosi TCFerencvárosi TC 1-3 Real Betis | UEFA Europa League Group G |
| 6 | Sun 3 Oct 2021 | 160-2 v VillarrealVillarreal 2-0 Real Betis | Spanish La Liga |
| 7 | Thu 21 Oct 2021 | 16 1-1 v Bayer 04 LeverkusenReal Betis 1-1 Bayer 04 Leverkusen | UEFA Europa League Group G |
| 8 | Wed 27 Oct 2021 | 164-1 v ValenciaReal Betis 4-1 Valencia | Spanish La Liga |
| 9 | Sun 31 Oct 2021 | 160-3 v Atlético MadridAtlético Madrid 3-0 Real Betis | Spanish La Liga |
| 10 | Sun 7 Nov 2021 | 160-2 v SevillaReal Betis 0-2 Sevilla | Spanish La Liga |
| 11 | Sun 21 Nov 2021 | 163-0 v ElcheElche 0-3 Real Betis | Spanish La Liga |
| 12 | Thu 9 Dec 2021 | 16 2-3 v CelticCeltic 3-2 Real Betis | UEFA Europa League Group G |
| 13 | Tue 18 Jan 2022 | 164-0 v AlavésReal Betis 4-0 Alavés | Spanish La Liga |
| 14 | Fri 21 Jan 2022 | 16 4-1 v EspanyolEspanyol 1-4 Real Betis | Spanish La Liga |
| 15 | Sun 6 Feb 2022 | 160-2 v VillarrealReal Betis 0-2 Villarreal | Spanish La Liga |
| 16 | Sun 13 Feb 2022 | 16 4-2 v LevanteLevante 2-4 Real Betis | Spanish La Liga |
| 17 | Thu 17 Feb 2022 | 163-2 v Zenit St PetersburgZenit St Petersburg 2-3 Real Betis | UEFA Europa League Round of 32 |
| 18 | Thu 24 Feb 2022 | 160-0 v Zenit St PetersburgReal Betis 0-0 Zenit St Petersburg | UEFA Europa League Round of 32 |
| 19 | Wed 9 Mar 2022 | 161-2 v Eintracht FrankfurtReal Betis 1-2 Eintracht Frankfurt | UEFA Europa League Round of 16 |
| 20 | Sun 13 Mar 2022 | 16 1-0 v Athletic BilbaoReal Betis 1-0 Athletic Bilbao | Spanish La Liga |
| 21 | Thu 17 Mar 2022 | 16 1-1 v Eintracht FrankfurtEintracht Frankfurt 1-1 Real Betis | UEFA Europa League Round of 16 |
| 22 | Sun 20 Mar 2022 | 16 0-0 v Celta VigoCelta Vigo 0-0 Real Betis | Spanish La Liga |
| 23 | Sat 9 Apr 2022 | 162-1 v CádizCádiz 1-2 Real Betis | Spanish La Liga |
| 24 | Fri 15 Apr 2022 | 160-0 v Real SociedadReal Sociedad 0-0 Real Betis | Spanish La Liga |
| 25 | Tue 19 Apr 2022 | 160-1 v ElcheReal Betis 0-1 Elche | Spanish La Liga |
| 26 | Mon 2 May 2022 | 160-0 v GetafeGetafe 0-0 Real Betis | Spanish La Liga |
| 27 | Sat 7 May 2022 | 161-2 v BarcelonaReal Betis 1-2 Barcelona | Spanish La Liga |
| 28 | Tue 10 May 2022 | 163-0 v ValenciaValencia 0-3 Real Betis | Spanish La Liga |
| 29 | Sun 15 May 2022 | 162-0 v GranadaReal Betis 2-0 Granada | Spanish La Liga |
| 30 | Fri 20 May 2022 | 160-0 v Real MadridReal Madrid 0-0 Real Betis | Spanish La Liga |
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