| 1 | 15/1/2022 | 501-2 v LensSaint Étienne 1-2 Lens | French Ligue 1 |
| 2 | 21/1/2022 | 500-1 v LyonLyon 1-0 Saint Étienne | French Ligue 1 |
| 3 | 26/1/2022 | 501-0 v AngersAngers 0-1 Saint Étienne | French Ligue 1 |
| 4 | 5/2/2022 | 503-1 v MontpellierSaint Étienne 3-1 Montpellier | French Ligue 1 |
| 5 | 13/2/2022 | 502-1 v ClermontClermont 1-2 Saint Étienne | French Ligue 1 |
| 6 | 20/2/2022 | 502-2 v StrasbourgSaint Étienne 2-2 Strasbourg | French Ligue 1 |
| 7 | 26/2/2022 | 501-3 v Paris St GermainParis St Germain 3-1 Saint Étienne | French Ligue 1 |
| 8 | 6/3/2022 | 501-0 v MetzSaint Étienne 1-0 Metz | French Ligue 1 |
| 9 | 11/3/2022 | 500-0 v LilleLille 0-0 Saint Étienne | French Ligue 1 |
| 10 | 18/3/2022 | 501-1 v TroyesSaint Étienne 1-1 Troyes | French Ligue 1 |
| 11 | 3/4/2022 | 502-4 v MarseilleSaint Étienne 2-4 Marseille | French Ligue 1 |
| 12 | 8/4/2022 | 502-6 v LorientLorient 6-2 Saint Étienne | French Ligue 1 |
| 13 | 16/4/2022 | 502-1 v BrestSaint Étienne 2-1 Brest | French Ligue 1 |
| 14 | 20/4/2022 | 502-2 v BordeauxBordeaux 2-2 Saint Étienne | French Ligue 1 |
| 15 | 23/4/2022 | 501-4 v MonacoSaint Étienne 1-4 Monaco | French Ligue 1 |
| 16 | 30/4/2022 | 500-2 v RennesRennes 2-0 Saint Étienne | French Ligue 1 |
| 17 | 11/5/2022 | 502-4 v NiceNice 4-2 Saint Étienne | French Ligue 1 |
| 18 | 14/5/2022 | 501-2 v ReimsSaint Étienne 1-2 Reims | French Ligue 1 |
| 19 | 21/5/2022 | 501-1 v NantesNantes 1-1 Saint Étienne | French Ligue 1 |
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