| 1 | 8/8/2021 | 101-1 v LorientSaint Étienne 1-1 Lorient | French Ligue 1 |
| 2 | 15/8/2021 | 102-2 v LensLens 2-2 Saint Étienne | French Ligue 1 |
| 3 | 21/8/2021 | 10 1-1 v LilleSaint Étienne 1-1 Lille | French Ligue 1 |
| 4 | 28/8/2021 | 10 1-3 v MarseilleMarseille 3-1 Saint Étienne | French Ligue 1 |
| 5 | 12/9/2021 | 100-2 v MontpellierMontpellier 2-0 Saint Étienne | French Ligue 1 |
| 6 | 18/9/2021 | 101-2 v BordeauxSaint Étienne 1-2 Bordeaux | French Ligue 1 |
| 7 | 22/9/2021 | 101-3 v MonacoMonaco 3-1 Saint Étienne | French Ligue 1 |
| 8 | 25/9/2021 | 100-3 v NiceSaint Étienne 0-3 Nice | French Ligue 1 |
| 9 | 3/10/2021 | 101-1 v LyonSaint Étienne 1-1 Lyon | French Ligue 1 |
| 10 | 17/10/2021 | 101-5 v StrasbourgStrasbourg 5-1 Saint Étienne | French Ligue 1 |
| 11 | 22/10/2021 | 102-2 v AngersSaint Étienne 2-2 Angers | French Ligue 1 |
| 12 | 30/10/2021 | 101-1 v MetzMetz 1-1 Saint Étienne | French Ligue 1 |
| 13 | 28/11/2021 | 101-3 v Paris St GermainSaint Étienne 1-3 Paris St Germain | French Ligue 1 |
| 14 | 1/12/2021 | 100-1 v BrestBrest 1-0 Saint Étienne | French Ligue 1 |
| 15 | 5/12/2021 | 100-5 v RennesSaint Étienne 0-5 Rennes | French Ligue 1 |
| 16 | 11/12/2021 | 10 0-2 v ReimsReims 2-0 Saint Étienne | French Ligue 1 |
| 17 | 22/12/2021 | 100-1 v NantesSaint Étienne 0-1 Nantes | French Ligue 1 |
| 18 | 5/2/2022 | 103-1 v MontpellierSaint Étienne 3-1 Montpellier | French Ligue 1 |
| 19 | 13/2/2022 | 102-1 v ClermontClermont 1-2 Saint Étienne | French Ligue 1 |
| 20 | 20/2/2022 | 102-2 v StrasbourgSaint Étienne 2-2 Strasbourg | French Ligue 1 |
| 21 | 6/3/2022 | 101-0 v MetzSaint Étienne 1-0 Metz | French Ligue 1 |
| 22 | 11/3/2022 | 100-0 v LilleLille 0-0 Saint Étienne | French Ligue 1 |
| 23 | 18/3/2022 | 10 1-1 v TroyesSaint Étienne 1-1 Troyes | French Ligue 1 |
| 24 | 16/4/2022 | 102-1 v BrestSaint Étienne 2-1 Brest | French Ligue 1 |
| 25 | 20/4/2022 | 10 2-2 v BordeauxBordeaux 2-2 Saint Étienne | French Ligue 1 |
| 26 | 23/4/2022 | 10 1-4 v MonacoSaint Étienne 1-4 Monaco | French Ligue 1 |
| 27 | 14/5/2022 | 101-2 v ReimsSaint Étienne 1-2 Reims | French Ligue 1 |
| 28 | 21/5/2022 | 101-1 v NantesNantes 1-1 Saint Étienne | French Ligue 1 |
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