| 1 | Sat 7 Aug 2021 | 41-1 v Leyton OrientSalford City 1-1 Leyton Orient | Sky Bet League Two |
| 2 | Sat 14 Aug 2021 | 4 0-0 v Sutton UnitedSalford City 0-0 Sutton United | Sky Bet League Two |
| 3 | Tue 17 Aug 2021 | 41-2 v Crawley TownCrawley Town 2-1 Salford City | Sky Bet League Two |
| 4 | Sat 21 Aug 2021 | 40-1 v Swindon TownSalford City 0-1 Swindon Town | Sky Bet League Two |
| 5 | Sat 28 Aug 2021 | 43-0 v Newport CountySalford City 3-0 Newport County | Sky Bet League Two |
| 6 | Sat 4 Sep 2021 | 4 1-2 v Carlisle UnitedCarlisle United 2-1 Salford City | Sky Bet League Two |
| 7 | Sat 11 Sep 2021 | 41-0 v Bradford CitySalford City 1-0 Bradford City | Sky Bet League Two |
| 8 | Sat 18 Sep 2021 | 4 0-2 v Tranmere RoversTranmere Rovers 2-0 Salford City | Sky Bet League Two |
| 9 | Sat 25 Sep 2021 | 4 2-2 v Northampton TownSalford City 2-2 Northampton Town | Sky Bet League Two |
| 10 | Sat 2 Oct 2021 | 42-0 v Colchester UnitedColchester United 0-2 Salford City | Sky Bet League Two |
| 11 | Sat 9 Oct 2021 | 41-2 v WalsallWalsall 2-1 Salford City | Sky Bet League Two |
| 12 | Sat 16 Oct 2021 | 42-0 v Hartlepool UnitedSalford City 2-0 Hartlepool United | Sky Bet League Two |
| 13 | Tue 19 Oct 2021 | 4 0-0 v RochdaleSalford City 0-0 Rochdale | Sky Bet League Two |
| 14 | Sat 30 Oct 2021 | 41-2 v Exeter CitySalford City 1-2 Exeter City | Sky Bet League Two |
| 15 | Mon 8 Nov 2021 | 41-0 v Dagenham & RedbridgeDagenham & Redbridge 0-1 Salford City | Emirates FA Cup First Round |
| 16 | Sat 13 Nov 2021 | 4 1-1 v Scunthorpe UnitedScunthorpe United 1-1 Salford City | Sky Bet League Two |
| 17 | Sat 20 Nov 2021 | 42-0 v Harrogate TownHarrogate Town 0-2 Salford City | Sky Bet League Two |
| 18 | Tue 23 Nov 2021 | 41-1 v Bristol RoversSalford City 1-1 Bristol Rovers | Sky Bet League Two |
| 19 | Sat 27 Nov 2021 | 42-0 v Oldham AthleticSalford City 2-0 Oldham Athletic | Sky Bet League Two |
| 20 | Sun 5 Dec 2021 | 40-2 v ChesterfieldSalford City 0-2 Chesterfield | Emirates FA Cup Second Round |
| 21 | Sat 11 Dec 2021 | 4 1-2 v Mansfield TownMansfield Town 2-1 Salford City | Sky Bet League Two |
| 22 | Sat 18 Dec 2021 | 41-0 v StevenageSalford City 1-0 Stevenage | Sky Bet League Two |
| 23 | Sat 8 Jan 2022 | 42-0 v Newport CountyNewport County 0-2 Salford City | Sky Bet League Two |
| 24 | Tue 11 Jan 2022 | 41-1 v Tranmere RoversSalford City 1-1 Tranmere Rovers | Sky Bet League Two |
| 25 | Sat 15 Jan 2022 | 41-2 v Bradford CityBradford City 2-1 Salford City | Sky Bet League Two |
| 26 | Tue 18 Jan 2022 | 41-0 v Port ValePort Vale 0-1 Salford City | Sky Bet League Two |
| 27 | Sat 22 Jan 2022 | 40-3 v Colchester UnitedSalford City 0-3 Colchester United | Sky Bet League Two |
| 28 | Tue 25 Jan 2022 | 42-0 v BarrowBarrow 0-2 Salford City | Sky Bet League Two |
| 29 | Sat 29 Jan 2022 | 4 0-1 v Northampton TownNorthampton Town 1-0 Salford City | Sky Bet League Two |
| 30 | Tue 1 Feb 2022 | 42-1 v Carlisle UnitedSalford City 2-1 Carlisle United | Sky Bet League Two |
| 31 | Tue 8 Feb 2022 | 40-0 v Sutton UnitedSutton United 0-0 Salford City | Sky Bet League Two |
| 32 | Sat 12 Feb 2022 | 42-0 v Leyton OrientLeyton Orient 0-2 Salford City | Sky Bet League Two |
| 33 | Sat 26 Feb 2022 | 42-1 v Swindon TownSwindon Town 1-2 Salford City | Sky Bet League Two |
| 34 | Sat 5 Mar 2022 | 41-1 v Forest Green RoversSalford City 1-1 Forest Green Rovers | Sky Bet League Two |
| 35 | Sat 12 Mar 2022 | 40-0 v Exeter CityExeter City 0-0 Salford City | Sky Bet League Two |
| 36 | Tue 15 Mar 2022 | 41-1 v RochdaleRochdale 1-1 Salford City | Sky Bet League Two |
| 37 | Sat 19 Mar 2022 | 45-1 v Scunthorpe UnitedSalford City 5-1 Scunthorpe United | Sky Bet League Two |
| 38 | Sat 26 Mar 2022 | 42-1 v WalsallSalford City 2-1 Walsall | Sky Bet League Two |
| 39 | Tue 29 Mar 2022 | 42-1 v Crawley TownSalford City 2-1 Crawley Town | Sky Bet League Two |
| 40 | Sat 2 Apr 2022 | 42-0 v Hartlepool UnitedHartlepool United 0-2 Salford City | Sky Bet League Two |
| 41 | Tue 5 Apr 2022 | 40-1 v Port ValeSalford City 0-1 Port Vale | Sky Bet League Two |
| 42 | Sat 9 Apr 2022 | 4 2-0 v Harrogate TownSalford City 2-0 Harrogate Town | Sky Bet League Two |
| 43 | Fri 15 Apr 2022 | 40-1 v Bristol RoversBristol Rovers 1-0 Salford City | Sky Bet League Two |
| 44 | Mon 18 Apr 2022 | 42-2 v BarrowSalford City 2-2 Barrow | Sky Bet League Two |
| 45 | Sat 23 Apr 2022 | 42-1 v Oldham AthleticOldham Athletic 1-2 Salford City | Sky Bet League Two |
| 46 | Mon 2 May 2022 | 4 2-2 v Mansfield TownSalford City 2-2 Mansfield Town | Sky Bet League Two |
| 47 | Sat 7 May 2022 | 42-4 v StevenageStevenage 4-2 Salford City | Sky Bet League Two |
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