| 1 | Sat 14 Aug 2021 | 9 0-0 v Sutton UnitedSalford City 0-0 Sutton United | Sky Bet League Two |
| 2 | Tue 17 Aug 2021 | 91-2 v Crawley TownCrawley Town 2-1 Salford City | Sky Bet League Two |
| 3 | Sat 21 Aug 2021 | 90-1 v Swindon TownSalford City 0-1 Swindon Town | Sky Bet League Two |
| 4 | Sat 4 Sep 2021 | 91-2 v Carlisle UnitedCarlisle United 2-1 Salford City | Sky Bet League Two |
| 5 | Sat 18 Sep 2021 | 90-2 v Tranmere RoversTranmere Rovers 2-0 Salford City | Sky Bet League Two |
| 6 | Sat 25 Sep 2021 | 92-2 v Northampton TownSalford City 2-2 Northampton Town | Sky Bet League Two |
| 7 | Sat 2 Oct 2021 | 92-0 v Colchester UnitedColchester United 0-2 Salford City | Sky Bet League Two |
| 8 | Sat 9 Oct 2021 | 91-2 v WalsallWalsall 2-1 Salford City | Sky Bet League Two |
| 9 | Sat 16 Oct 2021 | 9 2-0 v Hartlepool UnitedSalford City 2-0 Hartlepool United | Sky Bet League Two |
| 10 | Tue 19 Oct 2021 | 90-0 v RochdaleSalford City 0-0 Rochdale | Sky Bet League Two |
| 11 | Sat 23 Oct 2021 | 9 1-3 v Forest Green RoversForest Green Rovers 3-1 Salford City | Sky Bet League Two |
| 12 | Sat 30 Oct 2021 | 91-2 v Exeter CitySalford City 1-2 Exeter City | Sky Bet League Two |
| 13 | Tue 23 Nov 2021 | 9 1-1 v Bristol RoversSalford City 1-1 Bristol Rovers | Sky Bet League Two |
| 14 | Sat 27 Nov 2021 | 92-0 v Oldham AthleticSalford City 2-0 Oldham Athletic | Sky Bet League Two |
| 15 | Sun 5 Dec 2021 | 90-2 v ChesterfieldSalford City 0-2 Chesterfield | Emirates FA Cup Second Round |
| 16 | Sat 11 Dec 2021 | 91-2 v Mansfield TownMansfield Town 2-1 Salford City | Sky Bet League Two |
| 17 | Sat 18 Dec 2021 | 91-0 v StevenageSalford City 1-0 Stevenage | Sky Bet League Two |
| 18 | Sat 15 Jan 2022 | 91-2 v Bradford CityBradford City 2-1 Salford City | Sky Bet League Two |
| 19 | Tue 18 Jan 2022 | 91-0 v Port ValePort Vale 0-1 Salford City | Sky Bet League Two |
| 20 | Sat 22 Jan 2022 | 90-3 v Colchester UnitedSalford City 0-3 Colchester United | Sky Bet League Two |
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