| 1 | Fri 25 Sep 2020 | 261-0 v Sporting BragaSporting Braga 0-1 Santa Clara | Portuguese Primeira Liga |
| 2 | Sat 3 Oct 2020 | 260-0 v Gil VicenteSanta Clara 0-0 Gil Vicente | Portuguese Primeira Liga |
| 3 | Sun 18 Oct 2020 | 261-2 v Paços de FerreiraPaços de Ferreira 2-1 Santa Clara | Portuguese Primeira Liga |
| 4 | Sat 24 Oct 2020 | 261-2 v Sporting LisbonSanta Clara 1-2 Sporting Lisbon | Portuguese Primeira Liga |
| 5 | Sun 1 Nov 2020 | 26 2-1 v PortimonensePortimonense 1-2 Santa Clara | Portuguese Primeira Liga |
| 6 | Sat 7 Nov 2020 | 260-2 v TondelaTondela 2-0 Santa Clara | Portuguese Primeira Liga |
| 7 | Sat 28 Nov 2020 | 260-1 v FC PortoSanta Clara 0-1 FC Porto | Portuguese Primeira Liga |
| 8 | Sun 6 Dec 2020 | 263-1 v NacionalNacional 1-3 Santa Clara | Portuguese Primeira Liga |
| 9 | Mon 21 Dec 2020 | 260-4 v Vitória GuimarãesSanta Clara 0-4 Vitória Guimarães | Portuguese Primeira Liga |
| 10 | Tue 29 Dec 2020 | 260-1 v MoreirenseMoreirense 1-0 Santa Clara | Portuguese Primeira Liga |
| 11 | Mon 4 Jan 2021 | 261-1 v BenficaSanta Clara 1-1 Benfica | Portuguese Primeira Liga |
| 12 | Mon 1 Feb 2021 | 262-0 v BelenensesSanta Clara 2-0 Belenenses | Portuguese Primeira Liga |
| 13 | Mon 8 Feb 2021 | 262-1 v MarítimoMarítimo 1-2 Santa Clara | Portuguese Primeira Liga |
| 14 | Sun 14 Feb 2021 | 26 0-1 v Sporting BragaSanta Clara 0-1 Sporting Braga | Portuguese Primeira Liga |
| 15 | Sat 20 Feb 2021 | 260-1 v Gil VicenteGil Vicente 1-0 Santa Clara | Portuguese Primeira Liga |
| 16 | Sat 27 Feb 2021 | 263-0 v Paços de FerreiraSanta Clara 3-0 Paços de Ferreira | Portuguese Primeira Liga |
| 17 | Fri 5 Mar 2021 | 261-2 v Sporting LisbonSporting Lisbon 2-1 Santa Clara | Portuguese Primeira Liga |
| 18 | Mon 26 Apr 2021 | 261-2 v BenficaBenfica 2-1 Santa Clara | Portuguese Primeira Liga |
| 19 | Sat 1 May 2021 | 263-3 v BoavistaSanta Clara 3-3 Boavista | Portuguese Primeira Liga |
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