| 1 | Sun 27 Sep 2020 | 83-1 v CádizCádiz 1-3 Sevilla | Spanish La Liga |
| 2 | Thu 1 Oct 2020 | 81-0 v LevanteSevilla 1-0 Levante | Spanish La Liga |
| 3 | Sun 4 Oct 2020 | 81-1 v BarcelonaBarcelona 1-1 Sevilla | Spanish La Liga |
| 4 | Sat 17 Oct 2020 | 8 0-1 v GranadaGranada 1-0 Sevilla | Spanish La Liga |
| 5 | Tue 20 Oct 2020 | 8 0-0 v ChelseaChelsea 0-0 Sevilla | UEFA Champions League Group E |
| 6 | Wed 28 Oct 2020 | 81-0 v RennesSevilla 1-0 Rennes | UEFA Champions League Group E |
| 7 | Sat 31 Oct 2020 | 81-2 v Athletic BilbaoAthletic Bilbao 2-1 Sevilla | Spanish La Liga |
| 8 | Wed 4 Nov 2020 | 83-2 v FK KrasnodarSevilla 3-2 FK Krasnodar | UEFA Champions League Group E |
| 9 | Sat 7 Nov 2020 | 81-0 v OsasunaSevilla 1-0 Osasuna | Spanish La Liga |
| 10 | Sat 21 Nov 2020 | 84-2 v Celta VigoSevilla 4-2 Celta Vigo | Spanish La Liga |
| 11 | Tue 24 Nov 2020 | 8 2-1 v FK KrasnodarFK Krasnodar 1-2 Sevilla | UEFA Champions League Group E |
| 12 | Sat 28 Nov 2020 | 8 1-0 v HuescaHuesca 0-1 Sevilla | Spanish La Liga |
| 13 | Wed 2 Dec 2020 | 8 0-4 v ChelseaSevilla 0-4 Chelsea | UEFA Champions League Group E |
| 14 | Sat 5 Dec 2020 | 80-1 v Real MadridSevilla 0-1 Real Madrid | Spanish La Liga |
| 15 | Sat 12 Dec 2020 | 81-0 v GetafeGetafe 0-1 Sevilla | Spanish La Liga |
| 16 | Sat 19 Dec 2020 | 81-1 v Real ValladolidSevilla 1-1 Real Valladolid | Spanish La Liga |
| 17 | Tue 22 Dec 2020 | 8 1-0 v ValenciaValencia 0-1 Sevilla | Spanish La Liga |
| 18 | Tue 29 Dec 2020 | 82-0 v VillarrealSevilla 2-0 Villarreal | Spanish La Liga |
| 19 | Sat 2 Jan 2021 | 81-1 v Real BetisReal Betis 1-1 Sevilla | Spanish La Liga |
| 20 | Sat 9 Jan 2021 | 83-2 v Real SociedadSevilla 3-2 Real Sociedad | Spanish La Liga |
| 21 | Tue 12 Jan 2021 | 80-2 v Atlético MadridAtlético Madrid 2-0 Sevilla | Spanish La Liga |
| 22 | Tue 19 Jan 2021 | 82-1 v AlavésAlavés 1-2 Sevilla | Spanish La Liga |
| 23 | Sat 23 Jan 2021 | 83-0 v CádizSevilla 3-0 Cádiz | Spanish La Liga |
| 24 | Sat 30 Jan 2021 | 82-0 v EibarEibar 0-2 Sevilla | Spanish La Liga |
| 25 | Sat 6 Feb 2021 | 83-0 v GetafeSevilla 3-0 Getafe | Spanish La Liga |
| 26 | Sat 13 Feb 2021 | 81-0 v HuescaSevilla 1-0 Huesca | Spanish La Liga |
| 27 | Wed 17 Feb 2021 | 82-3 v Borussia DortmundSevilla 2-3 Borussia Dortmund | UEFA Champions League Round of 16 |
| 28 | Mon 22 Feb 2021 | 8 2-0 v OsasunaOsasuna 0-2 Sevilla | Spanish La Liga |
| 29 | Sat 27 Feb 2021 | 8 0-2 v BarcelonaSevilla 0-2 Barcelona | Spanish La Liga |
| 30 | Sat 6 Mar 2021 | 81-2 v ElcheElche 2-1 Sevilla | Spanish La Liga |
| 31 | Tue 9 Mar 2021 | 8 2-2 v Borussia DortmundBorussia Dortmund 2-2 Sevilla | UEFA Champions League Round of 16 |
| 32 | Sun 14 Mar 2021 | 8 1-0 v Real BetisSevilla 1-0 Real Betis | Spanish La Liga |
| 33 | Sat 20 Mar 2021 | 81-1 v Real ValladolidReal Valladolid 1-1 Sevilla | Spanish La Liga |
| 34 | Sun 4 Apr 2021 | 81-0 v Atlético MadridSevilla 1-0 Atlético Madrid | Spanish La Liga |
| 35 | Mon 12 Apr 2021 | 84-3 v Celta VigoCelta Vigo 3-4 Sevilla | Spanish La Liga |
| 36 | Sun 18 Apr 2021 | 8 2-1 v Real SociedadReal Sociedad 1-2 Sevilla | Spanish La Liga |
| 37 | Wed 21 Apr 2021 | 81-0 v LevanteLevante 0-1 Sevilla | Spanish La Liga |
| 38 | Sun 25 Apr 2021 | 82-1 v GranadaSevilla 2-1 Granada | Spanish La Liga |
| 39 | Mon 3 May 2021 | 80-1 v Athletic BilbaoSevilla 0-1 Athletic Bilbao | Spanish La Liga |
| 40 | Sun 9 May 2021 | 82-2 v Real MadridReal Madrid 2-2 Sevilla | Spanish La Liga |
| 41 | Wed 12 May 2021 | 81-0 v ValenciaSevilla 1-0 Valencia | Spanish La Liga |
| 42 | Sun 23 May 2021 | 81-0 v AlavésSevilla 1-0 Alavés | Spanish La Liga |
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