| 1 | Tue 21 Sep 2021 | 32-2 v SouthamptonSheffield United 2-2 Southampton | Carabao Cup Third Round |
| 2 | Sat 25 Sep 2021 | 31-0 v Derby CountySheffield United 1-0 Derby County | Sky Bet Championship |
| 3 | Tue 28 Sep 2021 | 3 0-2 v MiddlesbroughMiddlesbrough 2-0 Sheffield United | Sky Bet Championship |
| 4 | Sat 2 Oct 2021 | 31-2 v AFC BournemouthAFC Bournemouth 2-1 Sheffield United | Sky Bet Championship |
| 5 | Sat 16 Oct 2021 | 32-1 v Stoke CitySheffield United 2-1 Stoke City | Sky Bet Championship |
| 6 | Sun 24 Oct 2021 | 3 3-2 v BarnsleyBarnsley 2-3 Sheffield United | Sky Bet Championship |
| 7 | Sat 30 Oct 2021 | 30-1 v BlackpoolSheffield United 0-1 Blackpool | Sky Bet Championship |
| 8 | Tue 2 Nov 2021 | 31-1 v Nottingham ForestNottingham Forest 1-1 Sheffield United | Sky Bet Championship |
| 9 | Sat 6 Nov 2021 | 31-3 v Blackburn RoversBlackburn Rovers 3-1 Sheffield United | Sky Bet Championship |
| 10 | Sat 20 Nov 2021 | 30-0 v Coventry CitySheffield United 0-0 Coventry City | Sky Bet Championship |
| 11 | Tue 23 Nov 2021 | 31-0 v ReadingReading 0-1 Sheffield United | Sky Bet Championship |
| 12 | Sun 28 Nov 2021 | 32-0 v Bristol CitySheffield United 2-0 Bristol City | Sky Bet Championship |
| 13 | Sat 4 Dec 2021 | 33-2 v Cardiff CityCardiff City 2-3 Sheffield United | Sky Bet Championship |
| 14 | Mon 20 Dec 2021 | 31-0 v FulhamFulham 0-1 Sheffield United | Sky Bet Championship |
| 15 | Tue 18 Jan 2022 | 32-2 v Preston North EndPreston North End 2-2 Sheffield United | Sky Bet Championship |
| 16 | Tue 5 Apr 2022 | 31-0 v Queens Park RangersSheffield United 1-0 Queens Park Rangers | Sky Bet Championship |
| 17 | Sat 9 Apr 2022 | 3 0-0 v AFC BournemouthSheffield United 0-0 AFC Bournemouth | Sky Bet Championship |
| 18 | Fri 15 Apr 2022 | 31-2 v ReadingSheffield United 1-2 Reading | Sky Bet Championship |
| 19 | Mon 18 Apr 2022 | 31-1 v Bristol CityBristol City 1-1 Sheffield United | Sky Bet Championship |
| 20 | Sat 23 Apr 2022 | 31-0 v Cardiff CitySheffield United 1-0 Cardiff City | Sky Bet Championship |
| 21 | Fri 29 Apr 2022 | 33-1 v Queens Park RangersQueens Park Rangers 1-3 Sheffield United | Sky Bet Championship |
| 22 | Sat 7 May 2022 | 3 4-0 v FulhamSheffield United 4-0 Fulham | Sky Bet Championship |
| 23 | Sat 14 May 2022 | 31-2 v Nottingham ForestSheffield United 1-2 Nottingham Forest | Sky Bet Championship Play-off Semi Final |
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