| 1 | Sat 7 Aug 2021 | 40-1 v Birmingham CitySheffield United 0-1 Birmingham City | Sky Bet Championship |
| 2 | Wed 18 Aug 2021 | 40-4 v West Bromwich AlbionWest Bromwich Albion 4-0 Sheffield United | Sky Bet Championship |
| 3 | Sat 21 Aug 2021 | 41-2 v Huddersfield TownSheffield United 1-2 Huddersfield Town | Sky Bet Championship |
| 4 | Tue 24 Aug 2021 | 4 2-1 v Derby CountySheffield United 2-1 Derby County | Carabao Cup Second Round |
| 5 | Sat 28 Aug 2021 | 40-0 v Luton TownLuton Town 0-0 Sheffield United | Sky Bet Championship |
| 6 | Sat 11 Sep 2021 | 46-2 v Peterborough UnitedSheffield United 6-2 Peterborough United | Sky Bet Championship |
| 7 | Tue 14 Sep 2021 | 42-2 v Preston North EndSheffield United 2-2 Preston North End | Sky Bet Championship |
| 8 | Sat 18 Sep 2021 | 43-1 v Hull CityHull City 1-3 Sheffield United | Sky Bet Championship |
| 9 | Tue 21 Sep 2021 | 42-2 v SouthamptonSheffield United 2-2 Southampton | Carabao Cup Third Round |
| 10 | Sat 25 Sep 2021 | 41-0 v Derby CountySheffield United 1-0 Derby County | Sky Bet Championship |
| 11 | Tue 28 Sep 2021 | 4 0-2 v MiddlesbroughMiddlesbrough 2-0 Sheffield United | Sky Bet Championship |
| 12 | Sat 2 Oct 2021 | 4 1-2 v AFC BournemouthAFC Bournemouth 2-1 Sheffield United | Sky Bet Championship |
| 13 | Sat 16 Oct 2021 | 42-1 v Stoke CitySheffield United 2-1 Stoke City | Sky Bet Championship |
| 14 | Sun 24 Oct 2021 | 43-2 v BarnsleyBarnsley 2-3 Sheffield United | Sky Bet Championship |
| 15 | Sat 30 Oct 2021 | 40-1 v BlackpoolSheffield United 0-1 Blackpool | Sky Bet Championship |
| 16 | Tue 2 Nov 2021 | 41-1 v Nottingham ForestNottingham Forest 1-1 Sheffield United | Sky Bet Championship |
| 17 | Sat 6 Nov 2021 | 4 1-3 v Blackburn RoversBlackburn Rovers 3-1 Sheffield United | Sky Bet Championship |
| 18 | Sat 20 Nov 2021 | 40-0 v Coventry CitySheffield United 0-0 Coventry City | Sky Bet Championship |
| 19 | Tue 23 Nov 2021 | 4 1-0 v ReadingReading 0-1 Sheffield United | Sky Bet Championship |
| 20 | Mon 20 Dec 2021 | 41-0 v FulhamFulham 0-1 Sheffield United | Sky Bet Championship |
| 21 | Sat 29 Jan 2022 | 42-0 v Peterborough UnitedPeterborough United 0-2 Sheffield United | Sky Bet Championship |
| 22 | Fri 4 Feb 2022 | 42-1 v Birmingham CityBirmingham City 1-2 Sheffield United | Sky Bet Championship |
| 23 | Sat 12 Feb 2022 | 4 0-0 v Huddersfield TownHuddersfield Town 0-0 Sheffield United | Sky Bet Championship |
| 24 | Sat 19 Feb 2022 | 44-0 v Swansea CitySheffield United 4-0 Swansea City | Sky Bet Championship |
| 25 | Wed 23 Feb 2022 | 41-0 v Blackburn RoversSheffield United 1-0 Blackburn Rovers | Sky Bet Championship |
| 26 | Sat 26 Feb 2022 | 40-1 v MillwallMillwall 1-0 Sheffield United | Sky Bet Championship |
| 27 | Fri 4 Mar 2022 | 41-1 v Nottingham ForestSheffield United 1-1 Nottingham Forest | Sky Bet Championship |
| 28 | Tue 8 Mar 2022 | 44-1 v MiddlesbroughSheffield United 4-1 Middlesbrough | Sky Bet Championship |
| 29 | Sat 19 Mar 2022 | 42-0 v BarnsleySheffield United 2-0 Barnsley | Sky Bet Championship |
| 30 | Sat 2 Apr 2022 | 40-1 v Stoke CityStoke City 1-0 Sheffield United | Sky Bet Championship |
| 31 | Tue 5 Apr 2022 | 4 1-0 v Queens Park RangersSheffield United 1-0 Queens Park Rangers | Sky Bet Championship |
| 32 | Sat 9 Apr 2022 | 4 0-0 v AFC BournemouthSheffield United 0-0 AFC Bournemouth | Sky Bet Championship |
| 33 | Mon 18 Apr 2022 | 4 1-1 v Bristol CityBristol City 1-1 Sheffield United | Sky Bet Championship |
| 34 | Sat 23 Apr 2022 | 41-0 v Cardiff CitySheffield United 1-0 Cardiff City | Sky Bet Championship |
| 35 | Fri 29 Apr 2022 | 4 3-1 v Queens Park RangersQueens Park Rangers 1-3 Sheffield United | Sky Bet Championship |
| 36 | Sat 7 May 2022 | 4 4-0 v FulhamSheffield United 4-0 Fulham | Sky Bet Championship |
| 37 | Sat 14 May 2022 | 4 1-2 v Nottingham ForestSheffield United 1-2 Nottingham Forest | Sky Bet Championship Play-off Semi Final |
| 38 | Tue 17 May 2022 | 42-1 v Nottingham ForestNottingham Forest 1-2 Sheffield United | Sky Bet Championship Play-off Semi Final |
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