| 1 | 7/8/2021 | 40-1 v Birmingham CitySheffield United 0-1 Birmingham City | Sky Bet Championship |
| 2 | 18/8/2021 | 40-4 v West Bromwich AlbionWest Bromwich Albion 4-0 Sheffield United | Sky Bet Championship |
| 3 | 21/8/2021 | 41-2 v Huddersfield TownSheffield United 1-2 Huddersfield Town | Sky Bet Championship |
| 4 | 24/8/2021 | 4 2-1 v Derby CountySheffield United 2-1 Derby County | Carabao Cup Second Round |
| 5 | 28/8/2021 | 40-0 v Luton TownLuton Town 0-0 Sheffield United | Sky Bet Championship |
| 6 | 11/9/2021 | 46-2 v Peterborough UnitedSheffield United 6-2 Peterborough United | Sky Bet Championship |
| 7 | 14/9/2021 | 42-2 v Preston North EndSheffield United 2-2 Preston North End | Sky Bet Championship |
| 8 | 18/9/2021 | 43-1 v Hull CityHull City 1-3 Sheffield United | Sky Bet Championship |
| 9 | 21/9/2021 | 42-2 v SouthamptonSheffield United 2-2 Southampton | Carabao Cup Third Round |
| 10 | 25/9/2021 | 41-0 v Derby CountySheffield United 1-0 Derby County | Sky Bet Championship |
| 11 | 28/9/2021 | 4 0-2 v MiddlesbroughMiddlesbrough 2-0 Sheffield United | Sky Bet Championship |
| 12 | 2/10/2021 | 4 1-2 v AFC BournemouthAFC Bournemouth 2-1 Sheffield United | Sky Bet Championship |
| 13 | 16/10/2021 | 42-1 v Stoke CitySheffield United 2-1 Stoke City | Sky Bet Championship |
| 14 | 24/10/2021 | 43-2 v BarnsleyBarnsley 2-3 Sheffield United | Sky Bet Championship |
| 15 | 30/10/2021 | 40-1 v BlackpoolSheffield United 0-1 Blackpool | Sky Bet Championship |
| 16 | 2/11/2021 | 41-1 v Nottingham ForestNottingham Forest 1-1 Sheffield United | Sky Bet Championship |
| 17 | 6/11/2021 | 4 1-3 v Blackburn RoversBlackburn Rovers 3-1 Sheffield United | Sky Bet Championship |
| 18 | 20/11/2021 | 40-0 v Coventry CitySheffield United 0-0 Coventry City | Sky Bet Championship |
| 19 | 23/11/2021 | 4 1-0 v ReadingReading 0-1 Sheffield United | Sky Bet Championship |
| 20 | 20/12/2021 | 41-0 v FulhamFulham 0-1 Sheffield United | Sky Bet Championship |
| 21 | 29/1/2022 | 42-0 v Peterborough UnitedPeterborough United 0-2 Sheffield United | Sky Bet Championship |
| 22 | 4/2/2022 | 42-1 v Birmingham CityBirmingham City 1-2 Sheffield United | Sky Bet Championship |
| 23 | 12/2/2022 | 4 0-0 v Huddersfield TownHuddersfield Town 0-0 Sheffield United | Sky Bet Championship |
| 24 | 19/2/2022 | 44-0 v Swansea CitySheffield United 4-0 Swansea City | Sky Bet Championship |
| 25 | 23/2/2022 | 41-0 v Blackburn RoversSheffield United 1-0 Blackburn Rovers | Sky Bet Championship |
| 26 | 26/2/2022 | 40-1 v MillwallMillwall 1-0 Sheffield United | Sky Bet Championship |
| 27 | 4/3/2022 | 41-1 v Nottingham ForestSheffield United 1-1 Nottingham Forest | Sky Bet Championship |
| 28 | 8/3/2022 | 44-1 v MiddlesbroughSheffield United 4-1 Middlesbrough | Sky Bet Championship |
| 29 | 19/3/2022 | 42-0 v BarnsleySheffield United 2-0 Barnsley | Sky Bet Championship |
| 30 | 2/4/2022 | 40-1 v Stoke CityStoke City 1-0 Sheffield United | Sky Bet Championship |
| 31 | 5/4/2022 | 4 1-0 v Queens Park RangersSheffield United 1-0 Queens Park Rangers | Sky Bet Championship |
| 32 | 9/4/2022 | 4 0-0 v AFC BournemouthSheffield United 0-0 AFC Bournemouth | Sky Bet Championship |
| 33 | 18/4/2022 | 4 1-1 v Bristol CityBristol City 1-1 Sheffield United | Sky Bet Championship |
| 34 | 23/4/2022 | 41-0 v Cardiff CitySheffield United 1-0 Cardiff City | Sky Bet Championship |
| 35 | 29/4/2022 | 4 3-1 v Queens Park RangersQueens Park Rangers 1-3 Sheffield United | Sky Bet Championship |
| 36 | 7/5/2022 | 4 4-0 v FulhamSheffield United 4-0 Fulham | Sky Bet Championship |
| 37 | 14/5/2022 | 4 1-2 v Nottingham ForestSheffield United 1-2 Nottingham Forest | Sky Bet Championship Play-off Semi Final |
| 38 | 17/5/2022 | 42-1 v Nottingham ForestNottingham Forest 1-2 Sheffield United | Sky Bet Championship Play-off Semi Final |
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