| 1 | Sat 11 Sep 2021 | 276-2 v Peterborough UnitedSheffield United 6-2 Peterborough United | Sky Bet Championship |
| 2 | Tue 14 Sep 2021 | 272-2 v Preston North EndSheffield United 2-2 Preston North End | Sky Bet Championship |
| 3 | Sat 18 Sep 2021 | 273-1 v Hull CityHull City 1-3 Sheffield United | Sky Bet Championship |
| 4 | Sat 25 Sep 2021 | 27 1-0 v Derby CountySheffield United 1-0 Derby County | Sky Bet Championship |
| 5 | Tue 28 Sep 2021 | 270-2 v MiddlesbroughMiddlesbrough 2-0 Sheffield United | Sky Bet Championship |
| 6 | Sat 2 Oct 2021 | 271-2 v AFC BournemouthAFC Bournemouth 2-1 Sheffield United | Sky Bet Championship |
| 7 | Sat 16 Oct 2021 | 272-1 v Stoke CitySheffield United 2-1 Stoke City | Sky Bet Championship |
| 8 | Sat 30 Oct 2021 | 270-1 v BlackpoolSheffield United 0-1 Blackpool | Sky Bet Championship |
| 9 | Tue 2 Nov 2021 | 271-1 v Nottingham ForestNottingham Forest 1-1 Sheffield United | Sky Bet Championship |
| 10 | Sat 6 Nov 2021 | 271-3 v Blackburn RoversBlackburn Rovers 3-1 Sheffield United | Sky Bet Championship |
| 11 | Sat 20 Nov 2021 | 270-0 v Coventry CitySheffield United 0-0 Coventry City | Sky Bet Championship |
| 12 | Tue 23 Nov 2021 | 27 1-0 v ReadingReading 0-1 Sheffield United | Sky Bet Championship |
| 13 | Sun 28 Nov 2021 | 27 2-0 v Bristol CitySheffield United 2-0 Bristol City | Sky Bet Championship |
| 14 | Sat 4 Dec 2021 | 273-2 v Cardiff CityCardiff City 2-3 Sheffield United | Sky Bet Championship |
| 15 | Mon 20 Dec 2021 | 271-0 v FulhamFulham 0-1 Sheffield United | Sky Bet Championship |
| 16 | Wed 9 Feb 2022 | 272-0 v West Bromwich AlbionSheffield United 2-0 West Bromwich Albion | Sky Bet Championship |
| 17 | Sat 12 Feb 2022 | 270-0 v Huddersfield TownHuddersfield Town 0-0 Sheffield United | Sky Bet Championship |
| 18 | Tue 15 Feb 2022 | 270-0 v Hull CitySheffield United 0-0 Hull City | Sky Bet Championship |
| 19 | Sat 19 Feb 2022 | 274-0 v Swansea CitySheffield United 4-0 Swansea City | Sky Bet Championship |
| 20 | Wed 23 Feb 2022 | 27 1-0 v Blackburn RoversSheffield United 1-0 Blackburn Rovers | Sky Bet Championship |
| 21 | Sat 26 Feb 2022 | 270-1 v MillwallMillwall 1-0 Sheffield United | Sky Bet Championship |
| 22 | Fri 4 Mar 2022 | 271-1 v Nottingham ForestSheffield United 1-1 Nottingham Forest | Sky Bet Championship |
| 23 | Tue 8 Mar 2022 | 27 4-1 v MiddlesbroughSheffield United 4-1 Middlesbrough | Sky Bet Championship |
| 24 | Sat 12 Mar 2022 | 271-4 v Coventry CityCoventry City 4-1 Sheffield United | Sky Bet Championship |
| 25 | Wed 16 Mar 2022 | 270-0 v BlackpoolBlackpool 0-0 Sheffield United | Sky Bet Championship |
| 26 | Sat 19 Mar 2022 | 272-0 v BarnsleySheffield United 2-0 Barnsley | Sky Bet Championship |
| 27 | Sat 2 Apr 2022 | 270-1 v Stoke CityStoke City 1-0 Sheffield United | Sky Bet Championship |
| 28 | Tue 5 Apr 2022 | 271-0 v Queens Park RangersSheffield United 1-0 Queens Park Rangers | Sky Bet Championship |
| 29 | Sat 9 Apr 2022 | 270-0 v AFC BournemouthSheffield United 0-0 AFC Bournemouth | Sky Bet Championship |
| 30 | Fri 15 Apr 2022 | 27 1-2 v ReadingSheffield United 1-2 Reading | Sky Bet Championship |
| 31 | Mon 18 Apr 2022 | 271-1 v Bristol CityBristol City 1-1 Sheffield United | Sky Bet Championship |
| 32 | Sat 23 Apr 2022 | 271-0 v Cardiff CitySheffield United 1-0 Cardiff City | Sky Bet Championship |
| 33 | Fri 29 Apr 2022 | 273-1 v Queens Park RangersQueens Park Rangers 1-3 Sheffield United | Sky Bet Championship |
| 34 | Sat 7 May 2022 | 274-0 v FulhamSheffield United 4-0 Fulham | Sky Bet Championship |
| 35 | Sat 14 May 2022 | 271-2 v Nottingham ForestSheffield United 1-2 Nottingham Forest | Sky Bet Championship Play-off Semi Final |
| 36 | Tue 17 May 2022 | 272-1 v Nottingham ForestNottingham Forest 1-2 Sheffield United | Sky Bet Championship Play-off Semi Final |
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