| 1 | Sat 3 Oct 2020 | 5 1-1 v Queens Park RangersSheffield Wednesday 1-1 Queens Park Rangers | Sky Bet Championship |
| 2 | Sat 17 Oct 2020 | 51-0 v Birmingham CityBirmingham City 0-1 Sheffield Wednesday | Sky Bet Championship |
| 3 | Wed 21 Oct 2020 | 51-2 v BrentfordSheffield Wednesday 1-2 Brentford | Sky Bet Championship |
| 4 | Sat 24 Oct 2020 | 50-1 v Luton TownSheffield Wednesday 0-1 Luton Town | Sky Bet Championship |
| 5 | Wed 28 Oct 2020 | 50-3 v Rotherham UnitedRotherham United 3-0 Sheffield Wednesday | Sky Bet Championship |
| 6 | Sat 31 Oct 2020 | 5 0-1 v Wycombe WanderersWycombe Wanderers 1-0 Sheffield Wednesday | Sky Bet Championship |
| 7 | Tue 3 Nov 2020 | 51-0 v AFC BournemouthSheffield Wednesday 1-0 AFC Bournemouth | Sky Bet Championship |
| 8 | Sat 7 Nov 2020 | 50-0 v MillwallSheffield Wednesday 0-0 Millwall | Sky Bet Championship |
| 9 | Sat 21 Nov 2020 | 50-1 v Preston North EndPreston North End 1-0 Sheffield Wednesday | Sky Bet Championship |
| 10 | Wed 25 Nov 2020 | 51-1 v Swansea CitySwansea City 1-1 Sheffield Wednesday | Sky Bet Championship |
| 11 | Sat 28 Nov 2020 | 50-0 v Stoke CitySheffield Wednesday 0-0 Stoke City | Sky Bet Championship |
| 12 | Wed 2 Dec 2020 | 5 1-1 v ReadingSheffield Wednesday 1-1 Reading | Sky Bet Championship |
| 13 | Sat 5 Dec 2020 | 51-2 v Norwich CityNorwich City 2-1 Sheffield Wednesday | Sky Bet Championship |
| 14 | Tue 8 Dec 2020 | 50-2 v Huddersfield TownHuddersfield Town 2-0 Sheffield Wednesday | Sky Bet Championship |
| 15 | Sat 12 Dec 2020 | 51-2 v BarnsleySheffield Wednesday 1-2 Barnsley | Sky Bet Championship |
| 16 | Tue 15 Dec 2020 | 50-2 v Nottingham ForestNottingham Forest 2-0 Sheffield Wednesday | Sky Bet Championship |
| 17 | Sat 19 Dec 2020 | 51-0 v Coventry CitySheffield Wednesday 1-0 Coventry City | Sky Bet Championship |
| 18 | Sat 26 Dec 2020 | 51-1 v Blackburn RoversBlackburn Rovers 1-1 Sheffield Wednesday | Sky Bet Championship |
| 19 | Tue 29 Dec 2020 | 52-1 v MiddlesbroughSheffield Wednesday 2-1 Middlesbrough | Sky Bet Championship |
| 20 | Fri 1 Jan 2021 | 51-0 v Derby CountySheffield Wednesday 1-0 Derby County | Sky Bet Championship |
| 21 | Sat 9 Jan 2021 | 52-0 v Exeter CityExeter City 0-2 Sheffield Wednesday | Emirates FA Cup Third Round |
| 22 | Sun 24 Jan 2021 | 50-3 v EvertonEverton 3-0 Sheffield Wednesday | Emirates FA Cup Fourth Round |
| 23 | Wed 27 Jan 2021 | 50-2 v Coventry CityCoventry City 2-0 Sheffield Wednesday | Sky Bet Championship |
| 24 | Sat 30 Jan 2021 | 51-0 v Preston North EndSheffield Wednesday 1-0 Preston North End | Sky Bet Championship |
| 25 | Tue 2 Feb 2021 | 52-1 v AFC BournemouthAFC Bournemouth 1-2 Sheffield Wednesday | Sky Bet Championship |
| 26 | Sat 6 Feb 2021 | 51-4 v MillwallMillwall 4-1 Sheffield Wednesday | Sky Bet Championship |
| 27 | Tue 9 Feb 2021 | 52-0 v Wycombe WanderersSheffield Wednesday 2-0 Wycombe Wanderers | Sky Bet Championship |
| 28 | Tue 16 Feb 2021 | 50-1 v Stoke CityStoke City 1-0 Sheffield Wednesday | Sky Bet Championship |
| 29 | Sat 20 Feb 2021 | 50-1 v Birmingham CitySheffield Wednesday 0-1 Birmingham City | Sky Bet Championship |
| 30 | Wed 24 Feb 2021 | 50-3 v BrentfordBrentford 3-0 Sheffield Wednesday | Sky Bet Championship |
| 31 | Sat 27 Feb 2021 | 52-3 v Luton TownLuton Town 3-2 Sheffield Wednesday | Sky Bet Championship |
| 32 | Wed 3 Mar 2021 | 51-2 v Rotherham UnitedSheffield Wednesday 1-2 Rotherham United | Sky Bet Championship |
| 33 | Sat 6 Mar 2021 | 50-3 v ReadingReading 3-0 Sheffield Wednesday | Sky Bet Championship |
| 34 | Sun 14 Mar 2021 | 51-2 v Norwich CitySheffield Wednesday 1-2 Norwich City | Sky Bet Championship |
| 35 | Wed 17 Mar 2021 | 51-1 v Huddersfield TownSheffield Wednesday 1-1 Huddersfield Town | Sky Bet Championship |
| 36 | Sat 20 Mar 2021 | 5 2-1 v BarnsleyBarnsley 1-2 Sheffield Wednesday | Sky Bet Championship |
| 37 | Fri 2 Apr 2021 | 50-1 v WatfordWatford 1-0 Sheffield Wednesday | Sky Bet Championship |
| 38 | Mon 5 Apr 2021 | 55-0 v Cardiff CitySheffield Wednesday 5-0 Cardiff City | Sky Bet Championship |
| 39 | Sat 10 Apr 2021 | 51-4 v Queens Park RangersQueens Park Rangers 4-1 Sheffield Wednesday | Sky Bet Championship |
| 40 | Tue 13 Apr 2021 | 50-2 v Swansea CitySheffield Wednesday 0-2 Swansea City | Sky Bet Championship |
| 41 | Sat 17 Apr 2021 | 51-1 v Bristol CitySheffield Wednesday 1-1 Bristol City | Sky Bet Championship |
| 42 | Tue 20 Apr 2021 | 51-0 v Blackburn RoversSheffield Wednesday 1-0 Blackburn Rovers | Sky Bet Championship |
| 43 | Sat 24 Apr 2021 | 51-3 v MiddlesbroughMiddlesbrough 3-1 Sheffield Wednesday | Sky Bet Championship |
| 44 | Sat 1 May 2021 | 5 0-0 v Nottingham ForestSheffield Wednesday 0-0 Nottingham Forest | Sky Bet Championship |
| 45 | Sat 8 May 2021 | 53-3 v Derby CountyDerby County 3-3 Sheffield Wednesday | Sky Bet Championship |
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