| 1 | Sun 1 Aug 2021 | 170-0 v Huddersfield TownSheffield Wednesday 0-0 Huddersfield Town | Carabao Cup First Round |
| 2 | Sat 25 Sep 2021 | 171-1 v Ipswich TownIpswich Town 1-1 Sheffield Wednesday | Sky Bet League One |
| 3 | Sat 2 Oct 2021 | 171-2 v Oxford UnitedSheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 4 | Tue 5 Oct 2021 | 172-1 v Mansfield TownMansfield Town 1-2 Sheffield Wednesday | Papa John’s Trophy |
| 5 | Sat 16 Oct 2021 | 172-2 v AFC WimbledonAFC Wimbledon 2-2 Sheffield Wednesday | Sky Bet League One |
| 6 | Tue 19 Oct 2021 | 171-1 v Cambridge UnitedCambridge United 1-1 Sheffield Wednesday | Sky Bet League One |
| 7 | Sat 23 Oct 2021 | 171-1 v Lincoln CitySheffield Wednesday 1-1 Lincoln City | Sky Bet League One |
| 8 | Sat 30 Oct 2021 | 172-2 v Cheltenham TownCheltenham Town 2-2 Sheffield Wednesday | Sky Bet League One |
| 9 | Tue 2 Nov 2021 | 173-0 v SunderlandSheffield Wednesday 3-0 Sunderland | Sky Bet League One |
| 10 | Sun 7 Nov 2021 | 170-0 v Plymouth ArgyleSheffield Wednesday 0-0 Plymouth Argyle | Emirates FA Cup First Round |
| 11 | Tue 9 Nov 2021 | 174-0 v Harrogate TownSheffield Wednesday 4-0 Harrogate Town | Papa John’s Trophy |
| 12 | Sat 13 Nov 2021 | 171-1 v GillinghamSheffield Wednesday 1-1 Gillingham | Sky Bet League One |
| 13 | Tue 16 Nov 2021 | 170-3 v Plymouth ArgylePlymouth Argyle 3-0 Sheffield Wednesday | Emirates FA Cup First Round Replay |
| 14 | Sat 20 Nov 2021 | 173-2 v Accrington StanleyAccrington Stanley 2-3 Sheffield Wednesday | Sky Bet League One |
| 15 | Tue 23 Nov 2021 | 172-1 v Milton Keynes DonsSheffield Wednesday 2-1 Milton Keynes Dons | Sky Bet League One |
| 16 | Sat 27 Nov 2021 | 172-2 v Wycombe WanderersSheffield Wednesday 2-2 Wycombe Wanderers | Sky Bet League One |
| 17 | Tue 7 Dec 2021 | 170-0 v PortsmouthPortsmouth 0-0 Sheffield Wednesday | Sky Bet League One |
| 18 | Sat 11 Dec 2021 | 172-0 v Crewe AlexandraCrewe Alexandra 0-2 Sheffield Wednesday | Sky Bet League One |
| 19 | Thu 30 Dec 2021 | 170-5 v SunderlandSunderland 5-0 Sheffield Wednesday | Sky Bet League One |
| 20 | Sun 2 Jan 2022 | 170-1 v Shrewsbury TownShrewsbury Town 1-0 Sheffield Wednesday | Sky Bet League One |
| 21 | Sat 15 Jan 2022 | 174-2 v Plymouth ArgyleSheffield Wednesday 4-2 Plymouth Argyle | Sky Bet League One |
| 22 | Sat 22 Jan 2022 | 172-3 v Oxford UnitedOxford United 3-2 Sheffield Wednesday | Sky Bet League One |
| 23 | Sat 29 Jan 2022 | 171-0 v Ipswich TownSheffield Wednesday 1-0 Ipswich Town | Sky Bet League One |
| 24 | Tue 1 Feb 2022 | 172-0 v MorecambeSheffield Wednesday 2-0 Morecambe | Sky Bet League One |
| 25 | Sat 5 Mar 2022 | 171-3 v Lincoln CityLincoln City 3-1 Sheffield Wednesday | Sky Bet League One |
| 26 | Tue 15 Mar 2022 | 171-1 v Accrington StanleySheffield Wednesday 1-1 Accrington Stanley | Sky Bet League One |
| 27 | Sat 16 Apr 2022 | 173-2 v Milton Keynes DonsMilton Keynes Dons 2-3 Sheffield Wednesday | Sky Bet League One |
| 28 | Sat 23 Apr 2022 | 170-1 v Wycombe WanderersWycombe Wanderers 1-0 Sheffield Wednesday | Sky Bet League One |
| 29 | Sat 30 Apr 2022 | 174-1 v PortsmouthSheffield Wednesday 4-1 Portsmouth | Sky Bet League One |
| 30 | Fri 6 May 2022 | 170-1 v SunderlandSunderland 1-0 Sheffield Wednesday | Sky Bet League One Play-off Semi Final |
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