| 1 | Sat 11 Sep 2021 | 240-3 v Plymouth ArgylePlymouth Argyle 3-0 Sheffield Wednesday | Sky Bet League One |
| 2 | Sat 18 Sep 2021 | 241-1 v Shrewsbury TownSheffield Wednesday 1-1 Shrewsbury Town | Sky Bet League One |
| 3 | Sat 25 Sep 2021 | 241-1 v Ipswich TownIpswich Town 1-1 Sheffield Wednesday | Sky Bet League One |
| 4 | Sat 2 Oct 2021 | 241-2 v Oxford UnitedSheffield Wednesday 1-2 Oxford United | Sky Bet League One |
| 5 | Tue 5 Oct 2021 | 242-1 v Mansfield TownMansfield Town 1-2 Sheffield Wednesday | Papa John’s Trophy |
| 6 | Sat 9 Oct 2021 | 241-0 v Bolton WanderersSheffield Wednesday 1-0 Bolton Wanderers | Sky Bet League One |
| 7 | Sat 16 Oct 2021 | 242-2 v AFC WimbledonAFC Wimbledon 2-2 Sheffield Wednesday | Sky Bet League One |
| 8 | Tue 19 Oct 2021 | 401-1 v Cambridge UnitedCambridge United 1-1 Sheffield Wednesday | Sky Bet League One |
| 9 | Sat 23 Oct 2021 | 241-1 v Lincoln CitySheffield Wednesday 1-1 Lincoln City | Sky Bet League One |
| 10 | Sat 30 Oct 2021 | 242-2 v Cheltenham TownCheltenham Town 2-2 Sheffield Wednesday | Sky Bet League One |
| 11 | Tue 2 Nov 2021 | 243-0 v SunderlandSheffield Wednesday 3-0 Sunderland | Sky Bet League One |
| 12 | Sun 7 Nov 2021 | 240-0 v Plymouth ArgyleSheffield Wednesday 0-0 Plymouth Argyle | Emirates FA Cup First Round |
| 13 | Tue 9 Nov 2021 | 244-0 v Harrogate TownSheffield Wednesday 4-0 Harrogate Town | Papa John’s Trophy |
| 14 | Sat 13 Nov 2021 | 241-1 v GillinghamSheffield Wednesday 1-1 Gillingham | Sky Bet League One |
| 15 | Tue 16 Nov 2021 | 240-3 v Plymouth ArgylePlymouth Argyle 3-0 Sheffield Wednesday | Emirates FA Cup First Round Replay |
| 16 | Tue 23 Nov 2021 | 242-1 v Milton Keynes DonsSheffield Wednesday 2-1 Milton Keynes Dons | Sky Bet League One |
| 17 | Tue 7 Dec 2021 | 240-0 v PortsmouthPortsmouth 0-0 Sheffield Wednesday | Sky Bet League One |
| 18 | Sat 11 Dec 2021 | 242-0 v Crewe AlexandraCrewe Alexandra 0-2 Sheffield Wednesday | Sky Bet League One |
| 19 | Sun 2 Jan 2022 | 240-1 v Shrewsbury TownShrewsbury Town 1-0 Sheffield Wednesday | Sky Bet League One |
| 20 | Tue 1 Feb 2022 | 242-0 v MorecambeSheffield Wednesday 2-0 Morecambe | Sky Bet League One |
| 21 | Sat 19 Feb 2022 | 243-1 v Doncaster RoversDoncaster Rovers 1-3 Sheffield Wednesday | Sky Bet League One |
| 22 | Sat 26 Feb 2022 | 242-0 v Charlton AthleticSheffield Wednesday 2-0 Charlton Athletic | Sky Bet League One |
| 23 | Tue 1 Mar 2022 | 245-2 v Burton AlbionSheffield Wednesday 5-2 Burton Albion | Sky Bet League One |
| 24 | Sat 5 Mar 2022 | 241-3 v Lincoln CityLincoln City 3-1 Sheffield Wednesday | Sky Bet League One |
| 25 | Sat 12 Mar 2022 | 246-0 v Cambridge UnitedSheffield Wednesday 6-0 Cambridge United | Sky Bet League One |
| 26 | Tue 15 Mar 2022 | 241-1 v Accrington StanleySheffield Wednesday 1-1 Accrington Stanley | Sky Bet League One |
| 27 | Sat 19 Mar 2022 | 240-0 v GillinghamGillingham 0-0 Sheffield Wednesday | Sky Bet League One |
| 28 | Sat 2 Apr 2022 | 242-1 v AFC WimbledonSheffield Wednesday 2-1 AFC Wimbledon | Sky Bet League One |
| 29 | Sat 9 Apr 2022 | 241-1 v Bolton WanderersBolton Wanderers 1-1 Sheffield Wednesday | Sky Bet League One |
| 30 | Sat 16 Apr 2022 | 243-2 v Milton Keynes DonsMilton Keynes Dons 2-3 Sheffield Wednesday | Sky Bet League One |
| 31 | Tue 19 Apr 2022 | 241-0 v Crewe AlexandraSheffield Wednesday 1-0 Crewe Alexandra | Sky Bet League One |
| 32 | Sat 23 Apr 2022 | 240-1 v Wycombe WanderersWycombe Wanderers 1-0 Sheffield Wednesday | Sky Bet League One |
| 33 | Sat 30 Apr 2022 | 244-1 v PortsmouthSheffield Wednesday 4-1 Portsmouth | Sky Bet League One |
| 34 | Fri 6 May 2022 | 240-1 v SunderlandSunderland 1-0 Sheffield Wednesday | Sky Bet League One Play-off Semi Final |
| 35 | Mon 9 May 2022 | 241-1 v SunderlandSheffield Wednesday 1-1 Sunderland | Sky Bet League One Play-off Semi Final |
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