| 1 | 4/8/2018 | 10-3 v Borussia MönchengladbachSouthampton 0-3 Borussia Mönchengladbach | Friendly |
| 2 | 12/8/2018 | 10-0 v BurnleySouthampton 0-0 Burnley | Premier League |
| 3 | 18/8/2018 | 11-2 v EvertonEverton 2-1 Southampton | Premier League |
| 4 | 25/8/2018 | 11-2 v Leicester CitySouthampton 1-2 Leicester City | Premier League |
| 5 | 1/9/2018 | 12-0 v Crystal PalaceCrystal Palace 0-2 Southampton | Premier League |
| 6 | 17/9/2018 | 1 2-2 v Brighton & Hove AlbionSouthampton 2-2 Brighton & Hove Albion | Premier League |
| 7 | 22/9/2018 | 10-3 v LiverpoolLiverpool 3-0 Southampton | Premier League |
| 8 | 29/9/2018 | 10-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton | Premier League |
| 9 | 7/10/2018 | 10-3 v ChelseaSouthampton 0-3 Chelsea | Premier League |
| 10 | 20/10/2018 | 10-0 v AFC BournemouthAFC Bournemouth 0-0 Southampton | Premier League |
| 11 | 27/10/2018 | 10-0 v Newcastle UnitedSouthampton 0-0 Newcastle United | Premier League |
| 12 | 4/11/2018 | 11-6 v Manchester CityManchester City 6-1 Southampton | Premier League |
| 13 | 10/11/2018 | 11-1 v WatfordSouthampton 1-1 Watford | Premier League |
| 14 | 24/11/2018 | 12-3 v FulhamFulham 3-2 Southampton | Premier League |
| 15 | 1/12/2018 | 12-2 v Manchester UnitedSouthampton 2-2 Manchester United | Premier League |
| 16 | 5/12/2018 | 11-3 v Tottenham HotspurTottenham Hotspur 3-1 Southampton | Premier League |
| 17 | 8/12/2018 | 10-1 v Cardiff CityCardiff City 1-0 Southampton | Premier League |
| 18 | 16/12/2018 | 13-2 v ArsenalSouthampton 3-2 Arsenal | Premier League |
| 19 | 22/12/2018 | 13-1 v Huddersfield TownHuddersfield Town 1-3 Southampton | Premier League |
| 20 | 27/12/2018 | 11-2 v West Ham UnitedSouthampton 1-2 West Ham United | Premier League |
| 21 | 30/12/2018 | 11-3 v Manchester CitySouthampton 1-3 Manchester City | Premier League |
| 22 | 12/1/2019 | 12-1 v Leicester CityLeicester City 1-2 Southampton | Premier League |
| 23 | 19/1/2019 | 12-1 v EvertonSouthampton 2-1 Everton | Premier League |
| 24 | 30/1/2019 | 11-1 v Crystal PalaceSouthampton 1-1 Crystal Palace | Premier League |
| 25 | 2/2/2019 | 11-1 v BurnleyBurnley 1-1 Southampton | Premier League |
| 26 | 9/2/2019 | 11-2 v Cardiff CitySouthampton 1-2 Cardiff City | Premier League |
