| 1 | 4/8/2018 | 40-3 v Borussia MönchengladbachSouthampton 0-3 Borussia Mönchengladbach | Friendly |
| 2 | 12/8/2018 | 40-0 v BurnleySouthampton 0-0 Burnley | Premier League |
| 3 | 25/8/2018 | 41-2 v Leicester CitySouthampton 1-2 Leicester City | Premier League |
| 4 | 1/9/2018 | 4 2-0 v Crystal PalaceCrystal Palace 0-2 Southampton | Premier League |
| 5 | 17/9/2018 | 42-2 v Brighton & Hove AlbionSouthampton 2-2 Brighton & Hove Albion | Premier League |
| 6 | 22/9/2018 | 40-3 v LiverpoolLiverpool 3-0 Southampton | Premier League |
| 7 | 29/9/2018 | 40-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton | Premier League |
| 8 | 27/11/2018 | 40-0 v Leicester CityLeicester City 0-0 Southampton | Carabao Cup Fourth Round |
| 9 | 1/12/2018 | 4 2-2 v Manchester UnitedSouthampton 2-2 Manchester United | Premier League |
| 10 | 8/12/2018 | 40-1 v Cardiff CityCardiff City 1-0 Southampton | Premier League |
| 11 | 16/12/2018 | 43-2 v ArsenalSouthampton 3-2 Arsenal | Premier League |
| 12 | 22/12/2018 | 43-1 v Huddersfield TownHuddersfield Town 1-3 Southampton | Premier League |
| 13 | 27/12/2018 | 41-2 v West Ham UnitedSouthampton 1-2 West Ham United | Premier League |
| 14 | 2/1/2019 | 40-0 v ChelseaChelsea 0-0 Southampton | Premier League |
| 15 | 5/1/2019 | 42-2 v Derby CountyDerby County 2-2 Southampton | Emirates FA Cup Third Round |
| 16 | 12/1/2019 | 42-1 v Leicester CityLeicester City 1-2 Southampton | Premier League |
| 17 | 16/1/2019 | 42-2 v Derby CountySouthampton 2-2 Derby County | Emirates FA Cup Third Round Replay |
| 18 | 19/1/2019 | 42-1 v EvertonSouthampton 2-1 Everton | Premier League |
| 19 | 30/1/2019 | 41-1 v Crystal PalaceSouthampton 1-1 Crystal Palace | Premier League |
| 20 | 2/2/2019 | 41-1 v BurnleyBurnley 1-1 Southampton | Premier League |
| 21 | 9/2/2019 | 41-2 v Cardiff CitySouthampton 1-2 Cardiff City | Premier League |
| 22 | 24/2/2019 | 40-2 v ArsenalArsenal 2-0 Southampton | Premier League |
| 23 | 27/2/2019 | 42-0 v FulhamSouthampton 2-0 Fulham | Premier League |
| 24 | 2/3/2019 | 42-3 v Manchester UnitedManchester United 3-2 Southampton | Premier League |
| 25 | 9/3/2019 | 42-1 v Tottenham HotspurSouthampton 2-1 Tottenham Hotspur | Premier League |
| 26 | 5/4/2019 | 41-3 v LiverpoolSouthampton 1-3 Liverpool | Premier League |
| 27 | 13/4/2019 | 43-1 v Wolverhampton WanderersSouthampton 3-1 Wolverhampton Wanderers | Premier League |
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