| 1 | Sun 12 Aug 2018 | 220-0 v BurnleySouthampton 0-0 Burnley | Premier League |
| 2 | Sat 18 Aug 2018 | 221-2 v EvertonEverton 2-1 Southampton | Premier League |
| 3 | Sat 25 Aug 2018 | 221-2 v Leicester CitySouthampton 1-2 Leicester City | Premier League |
| 4 | Tue 28 Aug 2018 | 221-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-1 Southampton | Carabao Cup Second Round |
| 5 | Sat 1 Sep 2018 | 222-0 v Crystal PalaceCrystal Palace 0-2 Southampton | Premier League |
| 6 | Mon 17 Sep 2018 | 222-2 v Brighton & Hove AlbionSouthampton 2-2 Brighton & Hove Albion | Premier League |
| 7 | Sat 22 Sep 2018 | 220-3 v LiverpoolLiverpool 3-0 Southampton | Premier League |
| 8 | Sat 29 Sep 2018 | 220-2 v Wolverhampton WanderersWolverhampton Wanderers 2-0 Southampton | Premier League |
| 9 | Tue 2 Oct 2018 | 221-1 v EvertonEverton 1-1 Southampton | Carabao Cup Third Round |
| 10 | Sun 7 Oct 2018 | 220-3 v ChelseaSouthampton 0-3 Chelsea | Premier League |
| 11 | Sat 20 Oct 2018 | 220-0 v AFC BournemouthAFC Bournemouth 0-0 Southampton | Premier League |
| 12 | Sat 27 Oct 2018 | 220-0 v Newcastle UnitedSouthampton 0-0 Newcastle United | Premier League |
| 13 | Sun 4 Nov 2018 | 221-6 v Manchester CityManchester City 6-1 Southampton | Premier League |
| 14 | Sat 10 Nov 2018 | 221-1 v WatfordSouthampton 1-1 Watford | Premier League |
| 15 | Sat 24 Nov 2018 | 222-3 v FulhamFulham 3-2 Southampton | Premier League |
| 16 | Tue 27 Nov 2018 | 220-0 v Leicester CityLeicester City 0-0 Southampton | Carabao Cup Fourth Round |
| 17 | Sat 1 Dec 2018 | 222-2 v Manchester UnitedSouthampton 2-2 Manchester United | Premier League |
| 18 | Wed 5 Dec 2018 | 221-3 v Tottenham HotspurTottenham Hotspur 3-1 Southampton | Premier League |
| 19 | Sat 8 Dec 2018 | 220-1 v Cardiff CityCardiff City 1-0 Southampton | Premier League |
| 20 | Sun 16 Dec 2018 | 223-2 v ArsenalSouthampton 3-2 Arsenal | Premier League |
| 21 | Sat 22 Dec 2018 | 223-1 v Huddersfield TownHuddersfield Town 1-3 Southampton | Premier League |
| 22 | Thu 27 Dec 2018 | 221-2 v West Ham UnitedSouthampton 1-2 West Ham United | Premier League |
| 23 | Sun 30 Dec 2018 | 221-3 v Manchester CitySouthampton 1-3 Manchester City | Premier League |
| 24 | Wed 2 Jan 2019 | 220-0 v ChelseaChelsea 0-0 Southampton | Premier League |
| 25 | Sat 5 Jan 2019 | 222-2 v Derby CountyDerby County 2-2 Southampton | Emirates FA Cup Third Round |
| 26 | Sat 12 Jan 2019 | 222-1 v Leicester CityLeicester City 1-2 Southampton | Premier League |
| 27 | Wed 16 Jan 2019 | 222-2 v Derby CountySouthampton 2-2 Derby County | Emirates FA Cup Third Round Replay |
| 28 | Sat 19 Jan 2019 | 22 2-1 v EvertonSouthampton 2-1 Everton | Premier League |
| 29 | Wed 30 Jan 2019 | 221-1 v Crystal PalaceSouthampton 1-1 Crystal Palace | Premier League |
| 30 | Sat 2 Feb 2019 | 221-1 v BurnleyBurnley 1-1 Southampton | Premier League |
| 31 | Sat 9 Feb 2019 | 22 1-2 v Cardiff CitySouthampton 1-2 Cardiff City | Premier League |
| 32 | Sun 24 Feb 2019 | 220-2 v ArsenalArsenal 2-0 Southampton | Premier League |
| 33 | Wed 27 Feb 2019 | 222-0 v FulhamSouthampton 2-0 Fulham | Premier League |
| 34 | Sat 2 Mar 2019 | 222-3 v Manchester UnitedManchester United 3-2 Southampton | Premier League |
| 35 | Sat 9 Mar 2019 | 22 2-1 v Tottenham HotspurSouthampton 2-1 Tottenham Hotspur | Premier League |
| 36 | Sat 30 Mar 2019 | 221-0 v Brighton & Hove AlbionBrighton & Hove Albion 0-1 Southampton | Premier League |
| 37 | Fri 5 Apr 2019 | 221-3 v LiverpoolSouthampton 1-3 Liverpool | Premier League |
| 38 | Sat 13 Apr 2019 | 223-1 v Wolverhampton WanderersSouthampton 3-1 Wolverhampton Wanderers | Premier League |
| 39 | Sat 20 Apr 2019 | 221-3 v Newcastle UnitedNewcastle United 3-1 Southampton | Premier League |
| 40 | Tue 23 Apr 2019 | 221-1 v WatfordWatford 1-1 Southampton | Premier League |
| 41 | Sat 27 Apr 2019 | 223-3 v AFC BournemouthSouthampton 3-3 AFC Bournemouth | Premier League |
| 42 | Sat 4 May 2019 | 220-3 v West Ham UnitedWest Ham United 3-0 Southampton | Premier League |
| 43 | Sun 12 May 2019 | 221-1 v Huddersfield TownSouthampton 1-1 Huddersfield Town | Premier League |
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