| 1 | Sat 12 Sep 2020 | 40-1 v Crystal PalaceCrystal Palace 1-0 Southampton | Premier League |
| 2 | Sat 26 Sep 2020 | 41-0 v BurnleyBurnley 0-1 Southampton | Premier League |
| 3 | Sun 4 Oct 2020 | 42-0 v West Bromwich AlbionSouthampton 2-0 West Bromwich Albion | Premier League |
| 4 | Sat 17 Oct 2020 | 43-3 v ChelseaChelsea 3-3 Southampton | Premier League |
| 5 | Sun 25 Oct 2020 | 42-0 v EvertonSouthampton 2-0 Everton | Premier League |
| 6 | Sun 1 Nov 2020 | 44-3 v Aston VillaAston Villa 3-4 Southampton | Premier League |
| 7 | Fri 6 Nov 2020 | 42-0 v Newcastle UnitedSouthampton 2-0 Newcastle United | Premier League |
| 8 | Mon 23 Nov 2020 | 41-1 v Wolverhampton WanderersWolverhampton Wanderers 1-1 Southampton | Premier League |
| 9 | Sun 29 Nov 2020 | 42-3 v Manchester UnitedSouthampton 2-3 Manchester United | Premier League |
| 10 | Mon 7 Dec 2020 | 42-1 v Brighton & Hove AlbionBrighton & Hove Albion 1-2 Southampton | Premier League |
| 11 | Sun 13 Dec 2020 | 43-0 v Sheffield UnitedSouthampton 3-0 Sheffield United | Premier League |
| 12 | Wed 16 Dec 2020 | 41-1 v ArsenalArsenal 1-1 Southampton | Premier League |
| 13 | Sat 19 Dec 2020 | 40-1 v Manchester CitySouthampton 0-1 Manchester City | Premier League |
| 14 | Sat 6 Feb 2021 | 42-3 v Newcastle UnitedNewcastle United 3-2 Southampton | Premier League |
| 15 | Sun 14 Feb 2021 | 41-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 16 | Sat 20 Feb 2021 | 41-1 v ChelseaSouthampton 1-1 Chelsea | Premier League |
| 17 | Tue 23 Feb 2021 | 4 0-3 v Leeds UnitedLeeds United 3-0 Southampton | Premier League |
| 18 | Mon 1 Mar 2021 | 40-1 v EvertonEverton 1-0 Southampton | Premier League |
| 19 | Sat 6 Mar 2021 | 4 2-0 v Sheffield UnitedSheffield United 0-2 Southampton | Premier League |
| 20 | Wed 10 Mar 2021 | 42-5 v Manchester CityManchester City 5-2 Southampton | Premier League |
| 21 | Sun 14 Mar 2021 | 41-2 v Brighton & Hove AlbionSouthampton 1-2 Brighton & Hove Albion | Premier League |
| 22 | Sat 20 Mar 2021 | 4 3-0 v AFC BournemouthAFC Bournemouth 0-3 Southampton | Emirates FA Cup Sixth Round |
| 23 | Sun 4 Apr 2021 | 43-2 v BurnleySouthampton 3-2 Burnley | Premier League |
| 24 | Mon 12 Apr 2021 | 40-3 v West Bromwich AlbionWest Bromwich Albion 3-0 Southampton | Premier League |
| 25 | Sun 18 Apr 2021 | 40-1 v Leicester CityLeicester City 1-0 Southampton | Emirates FA Cup Semi Final |
| 26 | Wed 21 Apr 2021 | 41-2 v Tottenham HotspurTottenham Hotspur 2-1 Southampton | Premier League |
| 27 | Fri 30 Apr 2021 | 4 1-1 v Leicester CitySouthampton 1-1 Leicester City | Premier League |
| 28 | Sat 8 May 2021 | 40-2 v LiverpoolLiverpool 2-0 Southampton | Premier League |
| 29 | Tue 11 May 2021 | 4 3-1 v Crystal PalaceSouthampton 3-1 Crystal Palace | Premier League |
| 30 | Sat 15 May 2021 | 43-1 v FulhamSouthampton 3-1 Fulham | Premier League |
| 31 | Tue 18 May 2021 | 40-2 v Leeds UnitedSouthampton 0-2 Leeds United | Premier League |
| 32 | Sun 23 May 2021 | 40-3 v West Ham UnitedWest Ham United 3-0 Southampton | Premier League |
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