| 1 | Thu 11 Feb 2021 | 222-0 v Wolverhampton WanderersWolverhampton Wanderers 0-2 Southampton | Emirates FA Cup Fifth Round |
| 2 | Sun 14 Feb 2021 | 221-2 v Wolverhampton WanderersSouthampton 1-2 Wolverhampton Wanderers | Premier League |
| 3 | Sat 20 Feb 2021 | 221-1 v ChelseaSouthampton 1-1 Chelsea | Premier League |
| 4 | Tue 23 Feb 2021 | 220-3 v Leeds UnitedLeeds United 3-0 Southampton | Premier League |
| 5 | Mon 1 Mar 2021 | 220-1 v EvertonEverton 1-0 Southampton | Premier League |
| 6 | Wed 10 Mar 2021 | 222-5 v Manchester CityManchester City 5-2 Southampton | Premier League |
| 7 | Sat 20 Mar 2021 | 223-0 v AFC BournemouthAFC Bournemouth 0-3 Southampton | Emirates FA Cup Sixth Round |
| 8 | Sun 4 Apr 2021 | 223-2 v BurnleySouthampton 3-2 Burnley | Premier League |
| 9 | Sun 18 Apr 2021 | 220-1 v Leicester CityLeicester City 1-0 Southampton | Emirates FA Cup Semi Final |
| 10 | Wed 21 Apr 2021 | 221-2 v Tottenham HotspurTottenham Hotspur 2-1 Southampton | Premier League |
| 11 | Fri 30 Apr 2021 | 221-1 v Leicester CitySouthampton 1-1 Leicester City | Premier League |
| 12 | Tue 11 May 2021 | 223-1 v Crystal PalaceSouthampton 3-1 Crystal Palace | Premier League |
| 13 | Sat 15 May 2021 | 223-1 v FulhamSouthampton 3-1 Fulham | Premier League |
| 14 | Tue 18 May 2021 | 220-2 v Leeds UnitedSouthampton 0-2 Leeds United | Premier League |
| 15 | Sun 23 May 2021 | 22 0-3 v West Ham UnitedWest Ham United 3-0 Southampton | Premier League |
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