| 1 | Wed 16 Sep 2020 | 230-2 v BrentfordSouthampton 0-2 Brentford | Carabao Cup Second Round |
| 2 | Sun 20 Sep 2020 | 232-5 v Tottenham HotspurSouthampton 2-5 Tottenham Hotspur | Premier League |
| 3 | Sat 26 Sep 2020 | 231-0 v BurnleyBurnley 0-1 Southampton | Premier League |
| 4 | Sat 17 Oct 2020 | 233-3 v ChelseaChelsea 3-3 Southampton | Premier League |
| 5 | Sat 19 Dec 2020 | 230-1 v Manchester CitySouthampton 0-1 Manchester City | Premier League |
| 6 | Mon 4 Jan 2021 | 231-0 v LiverpoolSouthampton 1-0 Liverpool | Premier League |
| 7 | Thu 11 Feb 2021 | 232-0 v Wolverhampton WanderersWolverhampton Wanderers 0-2 Southampton | Emirates FA Cup Fifth Round |
| 8 | Sat 20 Feb 2021 | 231-1 v ChelseaSouthampton 1-1 Chelsea | Premier League |
| 9 | Tue 23 Feb 2021 | 230-3 v Leeds UnitedLeeds United 3-0 Southampton | Premier League |
| 10 | Mon 1 Mar 2021 | 23 0-1 v EvertonEverton 1-0 Southampton | Premier League |
| 11 | Sat 6 Mar 2021 | 23 2-0 v Sheffield UnitedSheffield United 0-2 Southampton | Premier League |
| 12 | Wed 10 Mar 2021 | 232-5 v Manchester CityManchester City 5-2 Southampton | Premier League |
| 13 | Sun 14 Mar 2021 | 231-2 v Brighton & Hove AlbionSouthampton 1-2 Brighton & Hove Albion | Premier League |
| 14 | Sat 20 Mar 2021 | 233-0 v AFC BournemouthAFC Bournemouth 0-3 Southampton | Emirates FA Cup Sixth Round |
| 15 | Mon 12 Apr 2021 | 230-3 v West Bromwich AlbionWest Bromwich Albion 3-0 Southampton | Premier League |
| 16 | Sun 18 Apr 2021 | 230-1 v Leicester CityLeicester City 1-0 Southampton | Emirates FA Cup Semi Final |
| 17 | Wed 21 Apr 2021 | 231-2 v Tottenham HotspurTottenham Hotspur 2-1 Southampton | Premier League |
| 18 | Fri 30 Apr 2021 | 231-1 v Leicester CitySouthampton 1-1 Leicester City | Premier League |
| 19 | Sat 8 May 2021 | 230-2 v LiverpoolLiverpool 2-0 Southampton | Premier League |
| 20 | Sat 15 May 2021 | 233-1 v FulhamSouthampton 3-1 Fulham | Premier League |
| 21 | Tue 18 May 2021 | 230-2 v Leeds UnitedSouthampton 0-2 Leeds United | Premier League |
| 22 | Sun 23 May 2021 | 230-3 v West Ham UnitedWest Ham United 3-0 Southampton | Premier League |
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